Автор: Babak Arjmand Название: Genomics, Proteomics, and Metabolomics ISBN: 3030277267 ISBN-13(EAN): 9783030277260 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Нет в наличии. Описание: This book provides thorough coverage of high-throughput OMICs technologies for the monitoring of stem cells and regenerative medicine. Specific topics covered include the genomics, proteomics, and metabolomics aspects of regenerative medicine, metabolic profiling of mesenchymal stem cells, genome profiling of mesenchymal stem cells, OMICs monitoring of stem cell-derived exosomes, stem cell proteomics, lipidomics, OMICs profiling of cancer (stem) cells, and finally ethical considerations of OMICs-based investigations. Chapters are authored by world-renowned scientists who have valuable expertise in the field of OMICs and regenerative medicine. Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers, clinicians, biologists, biochemists, and pharmaceutical experts conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, cellular therapy, OMICs, bioinformatics, and ethics.
Автор: Paul C. Guest Название: Reviews on Biomarker Studies in Aging and Anti-Aging Research ISBN: 3030256499 ISBN-13(EAN): 9783030256494 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies.
Автор: Angelo D`Alessandro Название: High-Throughput Metabolomics ISBN: 149399235X ISBN-13(EAN): 9781493992355 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This detailed volume focuses on recent technological, computational, and biostatistical advances in the field of high-throughput metabolomics. Chapters encompass methods, platforms, and analytical strategies for steady state measurements and metabolic flux analysis with stable isotope-labeled tracers, in biological matrices of clinical relevance and model organisms. Mass spectrometry-based or orthogonal methods are discussed, along with computational and statistical methods to address data sparsity in high-throughput metabolomics approaches. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, High-Throughput Metabolomics: Methods and Protocols provides tools that can bring about the next generation of clinical biochemistry in a cost-effective, rigorous fashion, exponentially advancing our capacity to investigate nature while hastening the advent of personalized medicine.
Автор: Jos?-Luis Capelo-Mart?nez Название: Emerging Sample Treatments in Proteomics ISBN: 3030122972 ISBN-13(EAN): 9783030122973 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proteomics is a well-established area of Science; yet with a strong area in constant evolution, namely sample treatment. There few books that currently cover the field of emerging sample treatments in proteomics, this new volume will be the first to cover all emerging and existing studies. This unique book presents the latest advances in the field focusing on emerging trends linked to high-resolution mass spectrometry, technology addressed to treat samples faster and to attempts to simplify the proteome for the reader.
Автор: Marco Aur?lio Zezzi Arruda Название: Metallomics ISBN: 3030079430 ISBN-13(EAN): 9783030079437 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.
Автор: Martin Giera Название: Clinical Metabolomics ISBN: 1493985302 ISBN-13(EAN): 9781493985302 Издательство: Springer Рейтинг: Цена: 79190.00 T Наличие на складе: Нет в наличии. Описание: This detailed volume presents a comprehensive compendium of clinical metabolomics protocols covering LC-MS, GC-MS, CE-MS, and NMR-based clinical metabolomics as well as bioinformatics and study design considerations. The methodologies explored here form the core of several very promising initiatives evolving around personalized health care and precision medicine, which can be seen as complimentary to the field of clinical chemistry and aid the aforementioned field with novel disease markers and diagnostic patterns. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Clinical Metabolomics: Methods and Protocols aims to serve as the basis for successful communication between scientists from several fields, including chemists, biologist, bioinformaticians, and clinicians, ultimately leading to effective study design and completion.
Автор: Raul Delgado-Morales Название: Neuroepigenomics in Aging and Disease ISBN: 3319852663 ISBN-13(EAN): 9783319852669 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.
Автор: M. Tomita; T. Nishioka Название: Metabolomics ISBN: 443199808X ISBN-13(EAN): 9784431998082 Издательство: Springer Рейтинг: Цена: 113180.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation.
Автор: Winkler Robert Название: Processing Metabolomics and Proteomics Data with Open Software: A Practical Guide ISBN: 1788017218 ISBN-13(EAN): 9781788017213 Издательство: Royal Society of Chemistry Рейтинг: Цена: 252030.00 T Наличие на складе: Нет в наличии. Описание: Metabolomics and proteomics allow deep insights into the chemistry and physiological processes of biological systems. This book will enable researchers, practitioners and students from different backgrounds to analyze metabolomics and proteomics mass spectrometry data.
Автор: Daniel Raftery Название: Mass Spectrometry in Metabolomics ISBN: 1493953192 ISBN-13(EAN): 9781493953196 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Part I. Historical and Methodology Overview
1. Overview: of Mass Spectrometry Based Metabolomics: Opportunities and Challenges
G. A. Nagana Gowda and Danijel Djukovic
Part II. Global LC-MS Based Metabolic Profiling
2. Global Metabolic Profiling using Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry
3. LC-MS Profiling to Link Metabolic and Phenotypic Diversity in Plant Mapping Populations
Camilla B. Hill, Antony Bacic, and Ute Roessner
4. Mitochondrial Metabolomics Using High-Resolution Fourier-Transform Mass Spectrometry
Young-Mi Go, Karan Uppal, Douglas I. Walker, ViLinh Tran, Lauriane Dury, Frederick H. Strobel, Hйlиne Baubichon-Cortay, Kurt D. Pennell, James R. Roede, and Dean P. Jones
5. Sample Preparation Methods for LC-MS Based Global Aqueous Metabolite Profiling
Antoni Beltran, Sara Samino, and Oscar Yanes
Part III. Global GC-MS and CE-MS Based Metabolic Profiling
6. Methods of Discovery-Based and Targeted Metabolite Analysis by Comprehensive Two-Dimensional Gas Chromatography with Time-of-Flight Mass Spectrometry Detection
Luke C. Marney, Dr. Jamin C. Hoggard, Kristen J. Skogerboe, and Robert E. Synovec
7. Analysis of Mouse Liver Metabolites by GCЧGC-TOF MS
Xue Shi, Xinmin Yin, and Xiang Zhang
8. Metabolite Fingerprinting by Capillary Electrophoresis-Mass Spectrometry
Antonia Garcia, Shama Naz, and Coral Barbas
Part IV. Isotope Labeling Methods
9. Quantitative Metabolomic Profiling using Dansylation Isotope Labeling and Liquid Chromatography Mass Spectrometry
Ruokun Zhou and Liang Li
10. Quantitative Analysis of Amino and Organic Acids by Methyl Chloroformate Derivatization and GC-MS/MS Analysis
Hans Fredrik Nyvold Kvitvang, Kеre A. Kristiansen, Stina K. Lien, and Per Bruheim
11. Stable Isotope Labeled Tracers for Metabolic Pathway Elucidation by GC-MS and FT-MS
Richard M. Higashi, Teresa W-M. Fan, Pawel K. Lorkiewicz, Hunter N.B. Moseley, and Andrew N. Lane
Part V. Targeted Aqueous Metabolite Profiling
12. Multiplexed, Quantitative and Targeted Metabolite Profiling by LC-MS/MRM
Ru Wei, Guodong Li, and Albert B. Seymour
Part VI. Lipid Profiling Methods
13. Multi-Dimensional Mass Spectrometry-Based Shotgun Lipidomics
Miao Wang and Xianlin Han
14. Comprehensive Quantitative Determination of PUFA-Related Bioactive Lipids for Functional Lipidomics using High Resolution Mass Spectrometry
Mojgan Masoodiand Dietrich A. Volmer
15. Ultra-Performance Liquid Chromatography Mass Spectrometry Targeted Profiling of Bile Acids: Application to Serum, Liver Tissue and Cultured Cells of Different Species
Juan Carlos Garcнa-Caсaveras, Marнa Teresa Donato, and Agustнn Lahoz
Part VII. Profiling Volatile Organic Compounds
16. Analysis of Volatile Organic Compounds in Exhaled Breath by Gas Chromatography-Mass Spectrometry combined with Chemometric Analysis
Jan W. Dallinga, Agnieszka Smolinska, and Frederik-Jan van Schooten
Part VIII. Profiling and Imaging using Atmospheric Sampling Methods
Автор: Karsten Suhre Название: Genetics Meets Metabolomics ISBN: 1489996958 ISBN-13(EAN): 9781489996954 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Written by leading researchers, this book explores the intersection of genetics and metabolomics, and points the way to more comprehensive studies of inborn variation of metabolism. All chapters refer to one or more published experimental datasets.
Название: Cancer Metabolomics 2018 ISBN: 3039213458 ISBN-13(EAN): 9783039213450 Издательство: Неизвестно Рейтинг: Цена: 54340.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.
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