Metabolism and Epigenetic Regulation: Implications in Cancer, Kundu
Название: Epigenetic cancer therapy ISBN: 0323913679 ISBN-13(EAN): 9780323913676 Издательство: Elsevier Science Рейтинг: Цена: 159450.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Cabej, Nelson R. (department Of Biology, Universit Название: Epigenetic mechanisms of the cambrian explosion ISBN: 0128143118 ISBN-13(EAN): 9780128143117 Издательство: Elsevier Science Рейтинг: Цена: 79710.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Epigenetic Mechanisms of the Cambrian Explosion provides readers with a basic biological knowledge and epigenetic explanation of the biological puzzle of the Cambrian explosion, the unprecedented rapid diversification of animals that began 542 million years ago. During an evolutionarily instant of 10 million years, which represents only 0.3% of the time of existence of life on Earth, or less than 2% of the time of existence of metazoans, all of the 30 extant body plans, major animal groups (phyla) and several extinct groups appeared. The work helps address this phenomena and tries to answer remaining questions for evolutionary biology, epigenetics, and scientific researchers.
The book recognizes and presents objective representations of alternative theories for epigenetic evolution in this period, with the author drawing on his epigenetic theory of evolution to explain the causal basis of the Cambrian explosion. Both empirical evidence and theoretical arguments are presented in support of this thought-provoking epigenetic theory.
Explains the Cambrian explosion from an entirely epigenetic view
Takes a causal rather than descriptive approach to the phenomenon
Allows for a broad readership, including those with only a basic biological knowledge, while maintaining scientific rigor
Автор: Mishra Manoj K., Bishnupuri Kumar S. Название: Epigenetic Advancements in Cancer ISBN: 3319797069 ISBN-13(EAN): 9783319797069 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease.
Автор: Michael L?bbert; Peter A. Jones Название: Epigenetic Therapy of Cancer ISBN: 3662519283 ISBN-13(EAN): 9783662519288 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
Автор: Ganai, Shabir Ahmad Название: Natural hdac inhibitors for epigenetic combating of cancer progression ISBN: 1032279869 ISBN-13(EAN): 9781032279862 Издательство: Taylor&Francis Рейтинг: Цена: 94930.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This Book entitled "Natural HDAC Inhibitors for Epigenetic Combating of Cancer Progression" deals only with HDAC inhibitors from natural origin including bacteria, fungi, marine organisms and notably from diverse plant sources.
Автор: Raffaele Teperino Название: Beyond Our Genes ISBN: 3030352129 ISBN-13(EAN): 9783030352127 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Невозможна поставка. Описание: The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.
Автор: Steven Gray Название: Epigenetic Cancer Therapy ISBN: 0128002069 ISBN-13(EAN): 9780128002063 Издательство: Elsevier Science Рейтинг: Цена: 116780.00 T Наличие на складе: Поставка под заказ. Описание:
Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.
The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).
The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.
Автор: Constanze Bonifer; Peter N. Cockerill Название: Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development ISBN: 3642451977 ISBN-13(EAN): 9783642451973 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes.
Автор: Constanze Bonifer; Peter N. Cockerill Название: Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development ISBN: 3662514664 ISBN-13(EAN): 9783662514665 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes.
Автор: Vladimir A. Botchkarev; Sarah E. Millar Название: Epigenetic Regulation of Skin Development and Regeneration ISBN: 3030132374 ISBN-13(EAN): 9783030132378 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Поставка под заказ. Описание: This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.
Автор: Torday John S. Название: Hormones and Reality: Epigenetic Regulation of the Endocrine System ISBN: 3030936902 ISBN-13(EAN): 9783030936907 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Cellular-molecular approach to evolution has led to radical changes in our understanding of biologic principles ranging from the Cell, to the Life Cycle, Development, Homeostasis, Senescence/Aging, Heterochrony, Pleiotropy, Phenotype, and perhaps the purpose of life itself. Much of this new way of thinking about biology and medicine emanates from experimental evidence for epigenetic inheritance. This leads one to question whether our unicellular state is the actual primary level of selection. One particular system that is now recognized as being under the auspices of epigenetic inheritance is the endocrine system, which is conventionally thought to regulate physiologic homeostasis. However, because the sex hormones play such a major role in behaviors related to the acquisition of epigenetic data, and the processing of such epigenetic data by the gonads during meiosis, their role in the evolution of the organism become tractable. The composite of the activities of the individual over the course of its lifetime can now be understood causally, resulting from the orchestration of its physiology by hormones, prenatally, postnatally and during the aging process, across the entire life span of the organism. Specific behaviors over the course of the life cycle during childhood, adolescence, puberty, adulthood and aging can now be understood mechanistically rather than merely as milestones in the various stages of life. With the above considerations in mind, this book presents the cellular-evolutionary perspective towards the relationship of the organism with its surroundings, human and non-human alike renders biology and medicine a continuum instead of fragmented, un-related anecdotes.
Автор: Vladimir Botchkarev; Sarah Millar Название: Epigenetic Regulation of Skin Development and Regeneration ISBN: 3319167685 ISBN-13(EAN): 9783319167688 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.
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