A molecule away from madness :, Peskin, Sara Manning,
Автор: Galizia, C. Giovanni; Lledo, Pierre-Marie (Eds.) Название: Neurosciences - From Molecule to Behavior: a university textbook ISBN: 3642107680 ISBN-13(EAN): 9783642107689 Издательство: Springer Рейтинг: Цена: 87200.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Neurosciences - a comprehensive approach This textbook covers neuroscience from cellular and molecular mechanisms to behavior and cognitive processing.
Despite their complex structures, molecules most likely do not take time to ponder the ways they fit into the big scheme of things. They just are. But when zillions of molecules bond into organized, functional systems, we get everything, including you and me - and some seven billion others. Chuck Champlin, a writer, journalist, and a former Walt Disney Co. communications executive, seeks inspiration via deep imaginative journeys into the infinitely vast and invisibly tiny realms of the cosmos in this small book with a big message. In observing molecular assemblies, we can see that physically matter came together, possibly all on its own, to create life and thinking minds. It is profound that our minds, perhaps born from accidental creativity, can intentionally assemble marvelous new things. To think like a molecule is to be aware of the physical foundations in matter that have given rise to our thoughts - and from there, it's onward into the realm of pure imaginations and the twinkling stars of our infinite potential.
Автор: Cipolla Marilyn J. Название: The Cerebral Circulation ISBN: 1615047220 ISBN-13(EAN): 9781615047222 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 29260.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
Автор: Gizem Kurt, Hillary L. Woodworth, Gina M. Leinninger Название: Lateral Hypothalamic Control of Energy Balance ISBN: 1615047670 ISBN-13(EAN): 9781615047673 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 58480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Reviews the essential role of the lateral hypothalamic area (LHA) for the control of body weight, from its historical description as a "feeding centre" to the current view of this LHA as a cellularly heterogeneous hub that regulates multiple aspects of physiology to influence body weight. The authors also evaluate how specific LHA populations coordinate certain metabolic cues and behaviours.
Автор: Rao N. Jaladanki, Jian-Ying Wang Название: Regulation of Gastrointestinal Mucosal Growth ISBN: 1615047344 ISBN-13(EAN): 9781615047345 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 37620.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex.
Автор: Christian Lehmann, Juan Zhou, Charles C. Caldwell Название: Sepsis: Staging and Potential Future Therapies ISBN: 1615047565 ISBN-13(EAN): 9781615047567 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 46200.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical studies in this group of critically ill patients. This book provides an overview about the state of the art of sepsis diagnostics and potential future therapies.
Автор: Dimas G. de Oteyza; Celia Rogero Название: On-Surface Synthesis II ISBN: 303009331X ISBN-13(EAN): 9783030093310 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: On-surface synthesis is appearing as an extremely promising strategy to create organic nanoarchitectures with atomic precision. Molecular building blocks holding adequate functional groups are dosed onto surfaces that support or even drive their covalent linkage. The surface confinement and the frequent lack of solvents (most commonly being performed under vacuum conditions) create a completely new scenario fully complementary to conventional chemistry. In a pedagogical way and based on the most recent developments, this volume presents our current understanding in the field, addressing fundamental reaction mechanisms, synthetic strategies to influence the reactions according to our needs, as well as the ultimate growth and characterization of functional materials.Verging on chemistry, physics and materials science, the book is aimed at students and researchers interested in nanochemistry, surface science, supramolecular materials and molecular devices.Chapters 'Mechanistic insights into surface-supported chemical reactions', 'Reactivity on and of Graphene Layers: Scanning Probe Microscopy Reviels' and 'Bottom-up fabrication of atomically precise graphene nanoribbons' of this book are available open access under a CC BY 4.0 license at link.springer.com
Автор: Lane Название: Oxygen: The molecule that made the world ISBN: 0198607830 ISBN-13(EAN): 9780198607830 Издательство: Oxford Academ Рейтинг: Цена: 10550.00 T Наличие на складе: Поставка под заказ. Описание: Oxygen is the engine of life and evolution. This book explores the impact that oxygen has had on Earth, tracing the history of life from the very beginning. It explains the rise of animals and plants, the origin of two sexes, and the evolution of ageing and death.
Автор: Ulla C. Kopp Название: Neural Control of Renal Function ISBN: 1615047778 ISBN-13(EAN): 9781615047772 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 58480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of α1-adrenoceptors and increase renin secretion rate by activation of β1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Under normal conditions, the renal mechanosensory nerves activated by stretch of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension.
Автор: Makarov, Dmitrii E. Название: Single Molecule Science ISBN: 036757571X ISBN-13(EAN): 9780367575717 Издательство: Taylor&Francis Рейтинг: Цена: 48990.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The observation and manipulation of individual molecules is one of the most exciting developments in modern molecular science, and the utility of single-molecule methods has proven invaluable in such fields as nanoscience and molecular biology. This book provides a general framework necessary for understanding single-molecule phenomena. It intro
Автор: J. Winny Yun, J. Steven Alexander Название: The Lymphatic System in Health and Disease ISBN: 1615047913 ISBN-13(EAN): 9781615047918 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 37580.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The lymphatic system develops and functions in parallel with the blood circulatory system (termed the ""hemovasculature"") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens—providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar.This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.
Автор: Granger D. Neil, Morris James D., Kvietys Peter R. Название: Physiology and Pathophysiology of Digestion ISBN: 1615046968 ISBN-13(EAN): 9781615046966 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 83560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This collaboration of two physiologists and a gastroenterologist provides medical and graduate students, medical and surgical residents, and subspecialty fellows a comprehensive summary of digestive system physiology and addresses the pathophysiological processes that underlie some GI diseases. The textual approach proceeds by organ instead of the traditional organization followed by other GI textbooks. This approach lets the reader track the food bolus as it courses through the GI tract, learning on the way each organ's physiologic functions as the bolus directly or indirectly contacts it. The book is divided into three parts: (1) Chapters 1–3 include coverage of basic concepts that pertain to all (or most) organs of the digestive system, salivation, chewing, swallowing, and esophageal function, (2) Chapters 4–6 are focused on the major secretory organs (stomach, pancreas, liver) that assist in the assimilation of a meal, and (3) Chapters 7 and 8 address the motor, transport, and digestive functions of the small and large intestines. Each chapter includes its own pathophysiology and clinical correlation section that underscores the importance of the organ’s normal function.
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