Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery 9781839165641

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Автор: Christopher T Walsh, Yi Tang
Название: Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery
ISBN: 9781839165641
Издательство: Royal Society of Chemistry
Классификация:

Органическая химия

Энзимология

Молекулярная биология

ISBN-10: 1839165642
Обложка/Формат: Hardback
Страницы: 820
Вес: 1.78 кг.
Дата издания: 14.12.2022
Серия: Chemistry
Язык: English
Размер: 253 x 196 x 53
Читательская аудитория: College/higher education
Ключевые слова: Biochemistry,Biology, life sciences,Enzymology,Molecular biology,Organic chemistry, SCIENCE / Chemistry / Organic,SCIENCE / Life Sciences / Biochemistry,SCIENCE / Life Sciences / Molecular Biology
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Поставляется из: Англии
Описание:

Authored by leading experts in the enzymology of natural product biosynthesis, this completely revised and updated edition provides a description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500 000 – 600 000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism.

This second edition integrates many new findings into the sets of principles of the first edition that parsed categories of natural product chemistries into the underlying enzymatic mechanisms and the catalytic machinery for building the varied and complex end product metabolites. New chapters include evaluation of a core set of thermodynamically activated but kinetically stable metabolites that power both primary and secondary metabolic pathways. Also, after decades of uncertainty about the existence of various pericyclase classes, a series of genome mining, heterologous expression, and enzymatic activity characterization have validated a plethora of pericyclases over the past decade. The several types of pericyclases are involved in biosynthetic complexity generation of almost every major category of natural products.

This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, pharmacognocists and chemical ecologists, and bioengineers and synthetic biologists.

Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery, Christopher T Walsh, Yi Tang