Miyagawa Akihisa Acoustic Levitation-Based Trace-Level Biosensing: Design of Detection Systems and Applications to Real Samples 9789811614279

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Автор: Miyagawa Akihisa
Название: Acoustic Levitation-Based Trace-Level Biosensing: Design of Detection Systems and Applications to Real Samples
ISBN: 9789811614279
Издательство: Springer
Классификация:

Наукометрия и системы индексов

Аналитическая химия

Физическая химия

Биохимия

ISBN-10: 981161427X
Обложка/Формат: Paperback
Страницы: 108
Вес: 0.16 кг.
Дата издания: 05.05.2022
Серия: Springer theses
Язык: English
Издание: 1st ed. 2021
Иллюстрации: 60 tables, color; 44 illustrations, color; 18 illustrations, black and white; xii, 93 p. 62 illus., 44 illus. in color.
Размер: 23.39 x 15.60 x 0.56 cm
Читательская аудитория: Professional & vocational
Подзаголовок: Design of detection systems and applications to real samples
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book shows the availability and potential of the coupled acoustic-gravitational (CAG) field for trace-level biosensing. The proposed detection scheme also allows the evaluation of the kinetics and thermodynamics of the reaction occurring on a single microparticle (MP). This method has wide applicability in important fields, involving not only chemistry but also life, environmental, and medical sciences. The author proposes novel trace-level biosensing based on measurements of the levitation coordinate shift of an MP in the CAG field. The levitation coordinate of the MP in the CAG field is determined by its density and compressibility. The levitation coordinate shift is induced by the binding of gold nanoparticles (AuNPs) to the MP through interparticle reactions. Therefore, the quantity of molecules involved in the reaction can be determined from the levitation coordinate shift. The author demonstrates the zmol level detection for biotin, DNA/RNA, and organic molecules. In addition, the kinetics and thermodynamics are evaluated for various reactions occurring between the MP and AuNP, such as the avidin-biotin reaction, direct hybridization, sandwich hybridization, and aptamer-target complexation. This book provides a new concept based on the CAG field, in which the extent of a reaction is converted into the levitation coordinate shift, that is, “length.” The proposed method has many advantages over other methods, e.g., high biocompatibility, high applicability, and short analysis time. In addition, because the apparatus used in this study is inexpensive and easy to miniaturize, this method is useful in important practical fields, such as forensic and environmental science and diagnosis. Thus, this book inspires many researchers to apply the present method to their own fields of interest.
Дополнительное описание: 1. Introduction.- 2. Theory of Combined Acoustic-Gravitational Field.- 3. Principle of Detection Using Particle Levitation in a Coupled Acoustic-Gravitational Field.- 4. Detection of the Avidin-Biotin Reaction.- 5. Label-Free Detection for the DNA/RNA mol

Acoustic Levitation-Based Trace-Level Biosensing: Design of Detection Systems and Applications to Real Samples, Miyagawa Akihisa