Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer, Holvoet Paul

Автор: Muller Fabbri
Название: Non-coding RNAs and Cancer
ISBN: 146148443X ISBN-13(EAN): 9781461484431
Издательство: Springer
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Цена: 156720.00 T
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Описание: This book provides essential information of the biogenesis, physiology and de-regulation of non-coding RNAs in cancer. It guides the reader to the most widely and effectively used bioinformatic approaches to the study of miRNAs.

Автор: Navarro
Название: Long Non-Coding RNAs in Cancer
ISBN: 1071615831 ISBN-13(EAN): 9781071615836
Издательство: Springer
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Цена: 111790.00 T
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Описание: This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.

Автор: Holvoet Paul
Название: Non-Coding Rnas at the Cross-Road of Cardiometabolic Diseases and Cancer
ISBN: 3030688437 ISBN-13(EAN): 9783030688431
Издательство: Springer
Цена: 130430.00 T
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Описание: This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure.

Автор: Filipe Palavra; Fl?vio Reis; Daniela Marado; Arman
Название: Biomarkers of Cardiometabolic Risk, Inflammation and Disease
ISBN: 3319160176 ISBN-13(EAN): 9783319160177
Издательство: Springer
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Цена: 111790.00 T
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Описание: This book discusses recent advances in the area of cardiometabolic risk biomarkers of chronic inflammatory and cardiovascular disorders.

Автор: Xia Li; Juan Xu; Yun Xiao; Shangwei Ning; Yunpeng
Название: Non-coding RNAs in Complex Diseases
ISBN: 9811307180 ISBN-13(EAN): 9789811307188
Издательство: Springer
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Цена: 130430.00 T
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Описание: This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Автор: Xiao Junjie
Название: Non-Coding Rnas in Cardiovascular Diseases
ISBN: 9811516731 ISBN-13(EAN): 9789811516733
Издательство: Springer
Цена: 139750.00 T
Наличие на складе: Поставка под заказ.
Описание: The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects.

Автор: Xiao Junjie
Название: Non-Coding Rnas in Cardiovascular Diseases
ISBN: 9811516707 ISBN-13(EAN): 9789811516702
Издательство: Springer
Цена: 139750.00 T
Наличие на складе: Поставка под заказ.
Описание: The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects.

Автор: Xia Li; Juan Xu; Yun Xiao; Shangwei Ning; Yunpeng
Название: Non-coding RNAs in Complex Diseases
ISBN: 9811344868 ISBN-13(EAN): 9789811344862
Издательство: Springer
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Цена: 121110.00 T
Наличие на складе: Поставка под заказ.
Описание: This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Автор: Song
Название: The Long and Short Non-coding RNAs in Cancer Biology
ISBN: 9811014965 ISBN-13(EAN): 9789811014963
Издательство: Springer
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Цена: 156720.00 T
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Описание: The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

Автор: Slaby
Название: Non-coding RNAs in Colorectal Cancer
ISBN: 3319420577 ISBN-13(EAN): 9783319420578
Издательство: Springer
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Цена: 149060.00 T
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Описание: This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.

Автор: Navarro Alfons
Название: Long Non-Coding Rnas in Cancer
ISBN: 1071615807 ISBN-13(EAN): 9781071615805
Издательство: Springer
Цена: 111790.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization.

Автор: Song Erwei
Название: The Long and Short Non-Coding Rnas in Cancer Biology
ISBN: 9811093679 ISBN-13(EAN): 9789811093678
Издательство: Springer
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Цена: 139750.00 T
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Описание: Non-coding RNAs: New Players in Cancers.- The Working Modules of Long Non-coding RNAs in Cancer Cells.- Methods to Study Long Non-coding RNA Biology in Cancer.- Relationship between Non-coding RNA Dysregulation and Epigenetic Mechanisms in Cancer.- Non-coding RNAs in Growth and Death of Cancer Cells.- Non-coding RNAs in Cancer Cell Plasticity.- Non-coding RNAs in Regulation of Cancer Metabolic Reprogramming.- Non-coding RNAs in Tumor Angiogenesis.- Non-coding RNAs in Cancer Immunity.- Non-coding RNAs in Therapeutic Resistance of Cancer.- Non-coding RNAs Regulating Cancer Signaling Network.- Non-coding RNAs Regulating NFkB Signaling.- Non-coding RNAs Regulating p53 and c-Myc Signaling.- Viral Non-coding RNAs in Cancer Biology.- Non-coding RNAs in Cancer Diagnosis.- Therapeutic Potentials of Non-coding RNAs: Targeted Delivery of NcRNAs in Cancer Cells.