Coronaviruses and Other Novel Antiviral Targets, 57, 

Автор: Roy Kunal
Название: In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols
ISBN: 1071613650 ISBN-13(EAN): 9781071613658
Издательство: Springer
Цена: 222670.00 T
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Описание: This detailed book aims to provide an overview of novel bioinformatics resources for exploring diverse aspects of RNA biology. This edition focuses on methods dealing with non-coding RNA (miRNAs, circRNAs or lncRNAs), RNA modifications (m6A or RNA editing), single cell RNA-seq and statistical models to handle count data from RNA-seq experiments.

Автор: Erik De Clercq
Название: Targets for the Design of Antiviral Agents
ISBN: 1468447114 ISBN-13(EAN): 9781468447118
Издательство: Springer
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Описание: This pUblication contains the Review Lectures presented at a joint NATO Advanced Study Institute and FEES Advanced Study Course held at Les Arcs, Bourg-8aint-Maurice, France, from the 19th June - 2nd July 1983.

Автор: John Mills; Paul A. Volberding; Lawrence Corey
Название: Antiviral Chemotherapy 5
ISBN: 1461371503 ISBN-13(EAN): 9781461371502
Издательство: Springer
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Цена: 139750.00 T
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Описание: Scientists and clinicians attending the last "New Directions in Antiviral Therapy" conference in late 1994 could hardly have predicted the revolution in the management of patients with HIV infection that has occurred since.

Автор: Edwin Yunhao Gong
Название: Antiviral Methods and Protocols
ISBN: 1493960350 ISBN-13(EAN): 9781493960354
Издательство: Springer
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Цена: 111790.00 T
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Описание:

Part I: Human Immunodeficiency Virus Type 1 (HIV-1)

1. A Fluorescence-Based High Throughput Screening Assay to Identify HIV-1 Inhibitors

Peggy Geluykens, Koen Van Acker, Johan Vingerhoets, Christel Van den Eynde, Marnix Van Loock, and Gйry Dams

2. A Homogeneous Time-Resolved Fluorescence Assay to Identify Inhibitors of HIV-1 Fusion

Liesbet Smeulders, Lieve Bunkens, Inge Vereycken, Koen Van Acker, Pascale Holemans, Emmanuel Gustin, Marnix Van Loock, and Gйry Dams

3. Identification of HIV-1 Reverse Transcriptase Inhibitors Using a Scintillation Proximity Assay

Bertrand Van Schoubroeck, Marnix Van Loock, Tania Ivens, Pascale Dehertogh, Dirk Jochmans, and Gйry Dams

4. Biochemical Screening Assays to Identify HIV-1 Integrase Inhibitors

Marleen Clynhens, Alexandra Smets, Inge Vereycken, Marnix Van Loock, Reginald Clayton, Geert Meersseman, and Olivia Goethals

5. HIV-1 Genotyping of the Protease-Reverse Transcriptase and Integrase Genes to Detect Mutations that Confer Anti-Retroviral Resistance

Peter Van den Eede, Liesbeth Van Wesenbeeck, Yvan Verlinden, Maxim Feyaerts, Veerle Smits, Ann Verheyen, Leen Vanhooren, Alain Deloof, Jorge Villacian, and Theresa Pattery

Part II: Hepatitis Viruses

6. In Vitro Kinetic Profiling of Hepatitis C Virus NS3 Protease Inhibitors by Progress Curve Analysis

Rumin Zhang and William T. Windsor

7. A Novel Hepatitis C Virus NS5B Polymerase Assay of De Novo Initiated RNA Synthesis Directed from a Heteropolymeric RNA Template

Eric Ferrari and Hsueh-Cheng Huang

8. Selecting and Characterizing Drug-Resistant Hepatitis C Virus Replicon

Inge Vliegen, Leen Delang, and Johan Neyts

9. A Cellular Replicon-Based Phenotyping Assay to Determine Susceptibility of Hepatitis C Virus Clinical Isolates to NS3/4A Protease Inhibitors

Leen Vijgen, Jannick Verbeeck, Barbara Van Kerckhove, Jan Martin Berke, Diana Koletzki, Gregory Fanning, and Oliver Lenz

10. Expression and Purification of Hepatitis C Virus Protease from Clinical Samples

Liesbet van der Helm

11. Surface Plasmon Resonance as a Tool to Select Potent Drug Candidates for Hepatitis C Virus NS5B Polymerase

Erna Cleiren, Benoit Devogelaere, and Katleen Fierens

12. Amplification and Sequencing of the Hepatitis C Virus NS3/4A Protease and the NS5B Polymerase Regions for Genotypic Resistance Detection of Clinical Isolates of Subtypes 1a and 1b

Diana Koletzki, Theresa Pattery, Bart Fevery, Leen Vanhooren, and Lieven J. Stuyver

13. A Southern Blot Assay for Detection of Hepatitis B Virus Covalently Closed Circular DNA from Cell Cultures

Dawei Cai, Hui Nie, Ran Yan, Ju-Tao Guo, Timothy M. Block, and Haitao Guo

14. In Vitro Phenotyping of Recombinant Hepatitis B Virus Containing the Polymerase/Reverse Transcriptase Gene from Clinical Isolates

Yang Liu and Kathryn M. Kitrinos

Part III: Flaviviruses

15. Cell-Based Antiviral Assays for Screening and Profiling Inhibitors Against Dengue Virus

Edwin Yunhao Gong, Marleen Clynhens, Tania Ivens, Pedro Lory, Kenny Simmen, and Guenter Kraus

16. A Duplex Real-Time RT-PCR Assay for Profiling Inhibitors of Four Dengue Serotypes

Edwin Yunhao Gong, Alexandra Smets, Nick Verheyen, Marleen Clynhens, Emmanuel Gustin, Pedro Lory, and Guenter Kraus

17. High Throughput Screening Using Dengue Virus Reporter Genomes

Wolfgang Fischl and Ralf Bartenschlager

18. Fluorimetric and HPLC-Based Dengue Virus Protease Assays Using a FRET Substrate

Christoph Ni

Автор: MERLUZZI; ADAMS
Название: The Search for Antiviral Drugs
ISBN: 1489967206 ISBN-13(EAN): 9781489967206
Издательство: Springer
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Название: Antiviral agents, vaccines, and immunotherapies
ISBN: 0367393743 ISBN-13(EAN): 9780367393748
Издательство: Taylor&Francis
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Цена: 63280.00 T
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Описание: Providing an analysis of the benefits and limitations of every available drug, vaccine and immunotherapy used to control and prevent antiviral diseases, this unique and genuinely comprehensive text is unlike any other current reference of its kind.

Автор: D.C. Baker; C.K. Chu
Название: Nucleosides and Nucleotides as Antitumor and Antiviral Agents
ISBN: 1461362210 ISBN-13(EAN): 9781461362210
Издательство: Springer
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Цена: 46570.00 T
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Описание: More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease.

Автор: John Mills; Paul A. Volberding; Lawrence Corey
Название: Antiviral Chemotherapy 4
ISBN: 1475792115 ISBN-13(EAN): 9781475792119
Издательство: Springer
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Цена: 186330.00 T
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Описание: Proceedings of the Fourth Triennial Symposium held in San Francisco,California, November 10-12, 1994.

Автор: Driscoll
Название: Antiviral Drugs.2004
ISBN: 0566083108 ISBN-13(EAN): 9780566083105
Издательство: Wiley
Цена: 56970.00 T
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Описание: Viruses are microorganisms that are as varied in type as the plants and animals of the macroscopic world. A particularly virulent virus can infect and kill a human host, which is 10 million times larger. The human immune system is the first line of defense against any infectious organism. However, sometimes this protection proves inadequate to the viral challenge. In this situation humans attempt to provide additional aid in retarding viral reproduction through the use of antiviral drugs until an overwhelmed immune system is able to cope with the infection. This type of self-help is the object of antiviral drug research. "Antiviral Drugs" by John Driscoll provides up-to-date information on the classification, history, structure, preclinical development, bioactivity, pharmacology, and effectiveness of the 72 most important antiviral agents. A carefully researched collectionover 400 references places details of definitive recent antiviral research at the reader's fingertips. An appendix contains for each drug an at-a-glance, detailed sketch, which includes chemical structure and molecular formula, identification numbers, synonyms, physical properties, toxicities, and manufacturers. Introductory chapters describe where viruses fit into the world of microorganisms, explore the unique properties of DNA and RNA viruses, and show how new antiviral drugs are discovered and developed into useful medicines.

Автор: Edwin Yunhao Gong
Название: Antiviral Methods and Protocols
ISBN: 1627034838 ISBN-13(EAN): 9781627034838
Издательство: Springer
Рейтинг:
Цена: 111790.00 T
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Описание:

Part I: Human Immunodeficiency Virus Type 1 (HIV-1)

1. A Fluorescence-Based High Throughput Screening Assay to Identify HIV-1 Inhibitors

Peggy Geluykens, Koen Van Acker, Johan Vingerhoets, Christel Van den Eynde, Marnix Van Loock, and Gйry Dams

2. A Homogeneous Time-Resolved Fluorescence Assay to Identify Inhibitors of HIV-1 Fusion

Liesbet Smeulders, Lieve Bunkens, Inge Vereycken, Koen Van Acker, Pascale Holemans, Emmanuel Gustin, Marnix Van Loock, and Gйry Dams

3. Identification of HIV-1 Reverse Transcriptase Inhibitors Using a Scintillation Proximity Assay

Bertrand Van Schoubroeck, Marnix Van Loock, Tania Ivens, Pascale Dehertogh, Dirk Jochmans, and Gйry Dams

4. Biochemical Screening Assays to Identify HIV-1 Integrase Inhibitors

Marleen Clynhens, Alexandra Smets, Inge Vereycken, Marnix Van Loock, Reginald Clayton, Geert Meersseman, and Olivia Goethals

5. HIV-1 Genotyping of the Protease-Reverse Transcriptase and Integrase Genes to Detect Mutations that Confer Anti-Retroviral Resistance

Peter Van den Eede, Liesbeth Van Wesenbeeck, Yvan Verlinden, Maxim Feyaerts, Veerle Smits, Ann Verheyen, Leen Vanhooren, Alain Deloof, Jorge Villacian, and Theresa Pattery

Part II: Hepatitis Viruses

6. In Vitro Kinetic Profiling of Hepatitis C Virus NS3 Protease Inhibitors by Progress Curve Analysis

Rumin Zhang and William T. Windsor

7. A Novel Hepatitis C Virus NS5B Polymerase Assay of De Novo Initiated RNA Synthesis Directed from a Heteropolymeric RNA Template

Eric Ferrari and Hsueh-Cheng Huang

8. Selecting and Characterizing Drug-Resistant Hepatitis C Virus Replicon

Inge Vliegen, Leen Delang, and Johan Neyts

9. A Cellular Replicon-Based Phenotyping Assay to Determine Susceptibility of Hepatitis C Virus Clinical Isolates to NS3/4A Protease Inhibitors

Leen Vijgen, Jannick Verbeeck, Barbara Van Kerckhove, Jan Martin Berke, Diana Koletzki, Gregory Fanning, and Oliver Lenz

10. Expression and Purification of Hepatitis C Virus Protease from Clinical Samples

Liesbet van der Helm

11. Surface Plasmon Resonance as a Tool to Select Potent Drug Candidates for Hepatitis C Virus NS5B Polymerase

Erna Cleiren, Benoit Devogelaere, and Katleen Fierens

12. Amplification and Sequencing of the Hepatitis C Virus NS3/4A Protease and the NS5B Polymerase Regions for Genotypic Resistance Detection of Clinical Isolates of Subtypes 1a and 1b

Diana Koletzki, Theresa Pattery, Bart Fevery, Leen Vanhooren, and Lieven J. Stuyver

13. A Southern Blot Assay for Detection of Hepatitis B Virus Covalently Closed Circular DNA from Cell Cultures

Dawei Cai, Hui Nie, Ran Yan, Ju-Tao Guo, Timothy M. Block, and Haitao Guo

14. In Vitro Phenotyping of Recombinant Hepatitis B Virus Containing the Polymerase/Reverse Transcriptase Gene from Clinical Isolates

Yang Liu and Kathryn M. Kitrinos

Part III: Flaviviruses

15. Cell-Based Antiviral Assays for Screening and Profiling Inhibitors Against Dengue Virus

Edwin Yunhao Gong, Marleen Clynhens, Tania Ivens, Pedro Lory, Kenny Simmen, and Guenter Kraus

16. A Duplex Real-Time RT-PCR Assay for Profiling Inhibitors of Four Dengue Serotypes

Edwin Yunhao Gong, Alexandra Smets, Nick Verheyen, Marleen Clynhens, Emmanuel Gustin, Pedro Lory, and Guenter Kraus

17. High Throughput Screening Using Dengue Virus Reporter Genomes

Wolfgang Fischl and Ralf Bartenschlager

18. Fluorimetric and HPLC-Based Dengue Virus Protease Assays Using a FRET Substrate

Christoph Ni

Автор: Ralf Bartenschlager
Название: Hepatitis C Virus: From Molecular Virology to Antiviral Therapy
ISBN: 364242936X ISBN-13(EAN): 9783642429361
Издательство: Springer
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Цена: 148010.00 T
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Описание: Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected.

Автор: Fred E. Hahn
Название: Mechanism of Action of Antieukaryotic and Antiviral Compounds
ISBN: 3642464092 ISBN-13(EAN): 9783642464096
Издательство: Springer
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Цена: 93160.00 T
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Описание: When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan- isms for the purpose of competing with other microorganisms for survival in mixed ecological environments.