Single-cell Sequencing and Methylation: Methods and Clinical Applications, Yu Buwei, Zhang Jiaqiang, Zeng Yiming
Автор: Yu Buwei, Zhang Jiaqiang, Zeng Yiming Название: Single-Cell Sequencing and Methylation: Methods and Clinical Applications ISBN: 981154493X ISBN-13(EAN): 9789811544934 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers.
Название: Learning Line Workbook: Beginning Sequencing, PreK-K ISBN: 159673177X ISBN-13(EAN): 9781596731776 Издательство: Неизвестно Рейтинг: Цена: 5350.00 T Наличие на складе: Невозможна поставка. Описание: Provide early learners with engaging skill-specific practice in 32 full-color pages. Quick and captivating activities keep young learners focused as they practice important sequencing skills--and increase vocabulary, improve small motor skills, share stories, and more
Автор: Moore, Jo Ellen (Author), Evans, Joy (Illustrator) Название: Short Story Sequencing: Grades 1-2 ISBN: 1557990298 ISBN-13(EAN): 9781557990297 Издательство: Неизвестно Цена: 0.00 T Наличие на складе: Невозможна поставка. Описание: This book contains 20 stories of familiar "How to" activities, each told in four or six brief segments, that your students can cut and paste into a logical sequence. Each of the 20 stories is illustrated with line art of a fuzzy bear doing fun things like washing his dog, painting a fence or eating a pizza. The stories are written in simple sentences using pictures to illustrate difficult vocabulary.
Автор: Evans, Joy (Author), Evan-Moor Educational Publish Название: Fairy Tale Sequencing (Teacher) ISBN: 155799031X ISBN-13(EAN): 9781557990310 Издательство: Неизвестно Цена: 7350.00 T Наличие на складе: Невозможна поставка. Описание: This book contains 10 classic fairy tales for children to cut and glue into the correct sequence. Children cut out the sentences of the story and move them around until they have placed them into the correct order. Then, children glue the sentences onto an illustrated story page. Fairy tale stories to sequence include: - Goldilocks and the Three Bears - Little Red Riding Hood - The Gingerbread Boy - The Little Red Hen - The Three Billy Goats Gruff - The Three Little Pigs - Jack and the Beanstalk - The Fisherman and his Wife - The Emperor's New Clothes - Rumplestiltskin
Автор: Kohji Hasunuma Название: Quantum Biology: Methods to Cure Malignant Cancerous Cells into Cells with Reduced CpG Methylation Accessible to Eating Cell Systems ISBN: 1536147753 ISBN-13(EAN): 9781536147759 Издательство: Nova Science Рейтинг: Цена: 77080.00 T Наличие на складе: Невозможна поставка. Описание: The 3O2 generated by the photolysis process will accept enough energy from triplet-chlorophyll to provide the energy states of a singlet of oxygen (1O2), 1Δg, and 1Σg+, with emissions in the range of 200 500 m. The 1O2 would react with unsaturated fatty acids to form malondialdehyde (MDA).In humans, the methylation of CpG islands in cancerous cells is so high that the sensing ability of the occurrence of environmental changes to genes with CpG islands could be insufficient for genes with CpG islands. House-keeping genes function independently by sensing various types of information from neighboring cells, and supporting the proliferation of cells behaving as cancerous cells so that the cells achieve a malignant, metastatic state. The CpG island-controlled genes (47,000/human haploid genome) and CpG island-independent genes (33,000/human haploid genome) co-regulate in the normal cell systems.FAD, FMN, riboflavin, and derivatives of heme groups are well known as photosensitizers, which emit 1O2 with ROS in the solution in vivo. In sunlight, photosensitizers will function as the generators of 1O2 and ROS. During the daytime, there is a plentiful supply of 1O2 and ROS from the sunlight, and which inevitably constitutes the circadian rhythms of ROS. The repeated evolution of 1O2 and ROS would function to stimulate the methylation of CpG islands.The tubulin structures, extending from the plasma membrane to two centrosomes and located along the sides of the nucleus, are designated as asters. In darkness, the protein complex of NDPK-1/catalase is located in the plasma membrane. However, upon receiving light illumination, the NDPK-1/catalase function captures 1O2 using catalase. The NDPK-1 binds NADH and supplies electrons to bind 1O2 that is bound to the catalase, resulting in the release of a super oxide (O2.-). The NDPK/catalase protein complex located in the plasma membrane moves along the aster-forming tubulin structure to the cytosol. As a result, the nucleus is protected from 1O2 by the wall, which is composed of the NDPK-1/catalase complex.
Автор: Urszula Demkow Название: Clinical Applications for Next Generation Sequencing ISBN: 0128017392 ISBN-13(EAN): 9780128017395 Издательство: Elsevier Science Рейтинг: Цена: 83080.00 T Наличие на складе: Нет в наличии. Описание:
Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments.
Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients.
The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia.
Автор: Malcolm Billy Название: DNA Methylation: Principles, Methods and Mechanisms ISBN: 168286412X ISBN-13(EAN): 9781682864128 Издательство: Неизвестно Рейтинг: Цена: 161990.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: DNA Methylation can be defined as the method by which methyl groups act on the DNA in order to repress cell processes. DNA methylation is vital for the organic processes taking place inside the human body such as ageing, carcinogenesis and gene expression. The aim of this book is to present researchers that have transformed this discipline and added its advancement. From theories and research to practical applications, case studies related to all contemporary topics of relevance to this field have been included herein. This book will prove useful for students as well as experts in the fields of evolutionary biology, bioengineering, and biochemistry. It is an essential guide for both academicians as well as for those who wish to pursue this discipline further.
Автор: Lusser Alexandra Название: RNA Methylation: Methods and Protocols ISBN: 1493983040 ISBN-13(EAN): 9781493983049 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume provides a comprehensive collection of current methods and protocols to study posttranscriptional base modifications in RNA with special focus on methylation.
Автор: Moshe Szyf Название: DNA Methylation and Cancer Therapy ISBN: 1441934162 ISBN-13(EAN): 9781441934161 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation.
Автор: Atsushi Kaneda; Yu-ichi Tsukada Название: DNA and Histone Methylation as Cancer Targets ISBN: 3319597841 ISBN-13(EAN): 9783319597843 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.
Автор: J. Jost; H. Saluz Название: DNA Methylation ISBN: 3034899157 ISBN-13(EAN): 9783034899154 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The explosive increase in the number of publications dealing with DNA methylation attests to its importance and makes it impossible to write a comprehensive coverage of the literature within the scope of a general review. Since the publication of the 3 most recent books dealing with the subject (DNA methylation by Razin A.
Rapid technological developments have led to increasingly efficient sequencing approaches. Next Generation Sequencing (NGS) is increasingly common and has become cost-effective, generating an explosion of sequenced data that need to be analyzed. The skills required to apply computational analysis to target research on a wide range of applications that include identifying causes of cancer, vaccine design, new antibiotics, drug development, personalized medicine and higher crop yields in agriculture are highly sought after.
This invaluable book provides step-by-step guides to complex topics that make it easy for readers to perform essential analyses from raw sequenced data to answering important biological questions. It is an excellent hands-on material for teachers who conduct courses in bioinformatics and as a reference material for professionals. The chapters are written to be standalone recipes making it suitable for readers who wish to self-learn selected topics. Readers will gain skills necessary to work on sequenced data from NGS platforms and hence making themselves more attractive to employers who need skilled bioinformaticians to handle the deluge of data.
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