Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases, Cioffi Christopher L.

Автор: Browning David J.
Название: Retinal Vein OcclusionsEvidence-Based Management Retinal Vein OcclusionsEvidence-Based Management
ISBN: 1461434386 ISBN-13(EAN): 9781461434382
Издательство: Springer
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Цена: 143480.00 T
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Описание: After diabetic retinopathy, the varieties of retinal vein occlusion constitute the most prevalent category of retinal vascular disease. For macular edema associated with central retinal vein occlusion (CRVO), no effective therapy existed until 2009, despite decades of research and failed pilot therapies.

Автор: Ingrid Kreissig
Название: Vol. 1: Minimal Surgery for Retinal Detachment: Diagnostics, Segmental Buckling without Drainage, Case Presentations
ISBN: 3131110619 ISBN-13(EAN): 9783131110619
Издательство: Thieme Verlagsgruppe
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Цена: 49540.00 T
Наличие на складе: Нет в наличии.
Описание: Dr. Kreissig has spent a lifetime refining and teaching the minimalized approach to repairing retinal detachments. In this book, you will get the benefit of her experience -- in an easily accessible, pocket-sized handbook that fits into your lab coat and is also ideal for bedside or office consultation. The book is the first hands-on guide to the art of buckling, i.e., applying a minimum of buckling without vitrectomy for retinal reattachment. The text is excellently illustrated and written in a dialogue style. From completing the preoperative exam to making the diagnosis and choosing the surgical technique, this book provides the facts and guidelines to successfully perform minimal extraocular surgery. It includes instructions on finding the retinal break in phakic, aphakic and pseudophakic detachments the four rules to find the primary break are presented on the back cover for immediate access.Ophthalmologists, fellows in retinal and vitreous surgery, students and residents will find this information-packed manual essential for diagnosing and repairing retinal detachments. Reserve your copy today!

Автор: Cioffi Christopher L.
Название: Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases
ISBN: 3030566188 ISBN-13(EAN): 9783030566180
Издательство: Springer
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Цена: 279500.00 T
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Описание: This book reviews the current state of ocular drug therapy and future therapeutic opportunities for a wide variety of conditions, including Age-related Macular Degeneration, Diabetic Retinopathy and Macular Edema, Glaucoma, and Inherited Retinal Diseases. Retinal diseases are major contributors to moderate or severe vision impairment in adults aged 50 years and older. The respective patient populations for many of these indications is expected to significantly increase as the world population continues to grow older. An improved understanding of the etiological underpinnings of ocular degenerative diseases over the past decade has significantly bolstered ophthalmic drug discovery. In this volume, contributions from leading experts explore the unique challenges faced for ocular drug discovery and delivery providing the reader with detailed information on ocular pharmacokinetics, in vitro, ex vivo and in vivo models for retinal disease pathology and emerging gene therapy treatments. The book is intended for all researchers and clinicians who wish to increase their knowledge on the latest findings in ocular drug therapy.

Автор: Matthew M. LaVail; John Ash; Robert E. Anderson; J
Название: Retinal Degenerative Diseases
ISBN: 1493941739 ISBN-13(EAN): 9781493941735
Издательство: Springer
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Цена: 243800.00 T
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Описание: This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

Название: Atlas of inherited retinal diseases
ISBN: 3319950452 ISBN-13(EAN): 9783319950457
Издательство: Springer
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Цена: 204970.00 T
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Описание: This Atlas of Inherited Retinal Disorders provides a thorough overview of various inherited retinal dystrophies with emphasis on phenotype characteristics and how they relate to the most frequently encountered genes. It also meets the previously unmet needs of PhD students who will benefit from seeing the phenotypes of genes they work on and study. Further, because genetic-testing costs are quite high and spiraling higher, this Atlas will help geneticists familiarize themselves with the candidate gene approach to test patients’ genomes, enabling more cost-efficient testing. This invaluable atlas is organized into eight sections starting with an introduction to the basic knowledge on retinal imaging, followed by diseases listed according to inheritance pattern and disorders with extraocular manifestations grouped by defining features. This structure will be intuitive to clinicians and students studying inherited retinal disorders.

Автор: Robert E. Anderson; Joe G. Hollyfield; Matthew M.
Название: Retinal Degenerative Diseases
ISBN: 149395086X ISBN-13(EAN): 9781493950867
Издательство: Springer
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Цена: 307450.00 T
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Описание: Basic Science Underlying Retinal Degeneration.- Analysis of Genes Differentially Expressed During Retinal Degeneration in Three Mouse Models.- Regulation of Angiogenesis by Macrophages.- Protein Kinase C Regulates Rod Photoreceptor Differentiation Through Modulation of STAT3 Signaling.- Pigment Epithelium-derived Factor Receptor (PEDF-R): A Plasma Membrane-linked Phospholipase with PEDF Binding Affinity.- The Function of Oligomerization-Incompetent RDS in Rods.- The Association Between Telomere Length and Sensitivity to Apoptosis of HUVEC.- Photoreceptor Guanylate Cyclases and cGMP Phosphodiesterases in Zebrafish.- RDS in Cones Does Not Interact with the Beta Subunit of the Cyclic Nucleotide Gated Channel.- Increased Expression of TGF-?1 and Smad 4 on Oxygen-Induced Retinopathy in Neonatal Mice.- ZBED4, A Novel Retinal Protein Expressed in Cones and Mьller Cells.- Tubby-Like Protein 1 (Tulp1) Is Required for Normal Photoreceptor Synaptic Development.- Growth-Associated Protein43 (GAP43) Is a Biochemical Marker for the Whole Period of Fish Optic Nerve Regeneration.- Multiprotein Complexes of Retinitis Pigmentosa GTPase Regulator (RPGR), a Ciliary Protein Mutated in X-Linked Retinitis Pigmentosa (XLRP).- Misfolded Proteins and Retinal Dystrophies.- Neural Retina and MerTK-Independent Apical Polarity of ?v?5 Integrin Receptors in the Retinal Pigment Epithelium.- Mertk in Daily Retinal Phagocytosis: A History in the Making.- The Interphotoreceptor Retinoid Binding (IRBP) Is Essential for Normal Retinoid Processing in Cone Photoreceptors.- Aseptic Injury to Epithelial Cells Alters Cell Surface Complement Regulation in a Tissue Specific Fashion.- Role of Metalloproteases in Retinal Degeneration Induced by Violet and Blue Light.- Mitochondrial Decay and Impairment of Antioxidant Defenses in Aging RPE Cells.- Ciliary Transport of Opsin.- Effect of Hesperidin on Expression of Inducible Nitric Oxide Synthase in Cultured Rabbit Retinal Pigment Epithelial Cells.- Profiling MicroRNAs Differentially Expressed in Rabbit Retina.- Unexpected Transcriptional Activity of the Human VMD2 Promoter in Retinal Development.- Microarray Analysis of Hyperoxia Stressed Mouse Retina: Differential Gene Expression in the Inferior and Superior Region.- Photoreceptor Sensory Cilia and Inherited Retinal Degeneration.- Role of Elovl4 Protein in the Biosynthesis of Docosahexaenoic Acid.- Molecular Genetics and Candidate Genes.- Molecular Pathogenesis of Achromatopsia Associated with Mutations in the Cone Cyclic Nucleotide-Gated Channel CNGA3 Subunit.- Mutation Spectra in Autosomal Dominant and Recessive Retinitis Pigmentosa in Northern Sweden.- 1 Rhodopsin Mutations in Congenital Night Blindness.- GCAP1 Mutations Associated with Autosomal Dominant Cone Dystrophy.- Genotypic Analysis of X-linked Retinoschisis in Western Australia.- Mutation Frequency of IMPDH1 Gene of Han Population in Ganzhou City.- Diagnostic, Clinical, Cytopathological and Physiologic Aspects of Retinal Degeneration.- Reversible and Size-Selective Opening of the Inner Blood-Retina Barrier: A Novel Therapeutic Strategy.- Spectral Domain Optical Coherence Tomography and Adaptive Optics: Imaging Photoreceptor Layer Morphology to Interpret Preclinical Phenotypes.- Pharmacological Manipulation of Rhodopsin Retinitis Pigmentosa.- Targeted High-Throughput DNA Sequencing for Gene Discovery in Retinitis Pigmentosa.- Advances in Imaging of Stargardt Disease.- Protamine Sulfate Downregulates Vascular Endothelial Growth Factor (VEGF) Expression and Inhibits VEGF and Its Receptor Binding in Vitro.- Computer-Assisted Semi-Quantitative Analysis of Mouse Choroidal Density.- Thioredoxins 1 and 2 Protect Retinal Ganglion Cells from Pharmacologically Induced Oxidative Stress, Optic Nerve Transection and Ocular Hypertension.- Near-Infrared Light Protect the Photoreceptor from Light-Induced Damage in Rats.- BDNF Improves the Efficacy ERG Amplitude Maintenance by Transplantation of Retinal Stem Ce

Автор: T. Amemiya
Название: Retinal and Choroidal Vascular Changes and Systemic Diseases in Rats
ISBN: 4431683968 ISBN-13(EAN): 9784431683964
Издательство: Springer
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Цена: 102480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Retinal and choroidal vasculatures are easily affected by various systemic diseases, and changes in the retina can easily be observed with various procedures such as direct and indirect ophthalmoscopy, scanning laser ophthalmoscopy, fluorescein fundus angiography, and indocyanin green fundus angiography.

Автор: Chhablani
Название: Retinal and Choroidal Imaging in Systemic Diseases
ISBN: 9811354030 ISBN-13(EAN): 9789811354038
Издательство: Springer
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Цена: 102480.00 T
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Описание: This book explains the underlying rationale for retinal and choroidal imaging in the context of systemic diseases. However, imaging techniques like enhanced depth imaging, oximetry, adaptive optics, and retinal blood flowmetry have remained largely unexplored in connection with systemic diseases.

Автор: Spandau
Название: Pediatric Retinal Vascular Diseases
ISBN: 3030137007 ISBN-13(EAN): 9783030137007
Издательство: Springer
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Цена: 102480.00 T
Наличие на складе: Невозможна поставка.
Описание: This book provides comprehensive and up-to-date information on diagnosis, medical and surgical treatments for pediatric retinal vascular conditions, which are leading causes of childhood blindness throughout the world.

Автор: J. Fernando Ar?valo
Название: Retinal and Choroidal Manifestations of Selected Systemic Diseases
ISBN: 1493951289 ISBN-13(EAN): 9781493951284
Издательство: Springer
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Цена: 130430.00 T
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Описание: This text presents current information on retinal and choroidal manifestations of systemic diseases from leading experts in the field. Topics include retinal and choroidal manifestations of AIDS, pediatric diseases, toxicity of systemic drugs, diseases of the gastrointestinal tract, diffuse unilateral subacute neuroretinitis (DUSN), viral and fungal diseases, sarcoidosis, Beh?et's disease, carotid artery and renal diseases, changes related to pregnancy, intraocular lymphoma, and more. Their knowledge and experience will assist ophthalmologists, retina specialists, uveitis and ocular oncology specialists, and general physicians approach a level of knowledge about retinal and choroidal manifestations of systemic diseases to benefit patients in everyday clinical practice.

Автор: Bowes Rickman Catherine, Grimm Christian, Anderson Robert E.
Название: Retinal Degenerative Diseases: Mechanisms and Experimental Therapy
ISBN: 3030273806 ISBN-13(EAN): 9783030273804
Издательство: Springer
Цена: 307450.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.

Автор: Ash
Название: Retinal Degenerative Diseases
ISBN: 3319754017 ISBN-13(EAN): 9783319754017
Издательство: Springer
Рейтинг:
Цена: 279500.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.