Atlas of Lymphoscintigraphy and Sentinel Node Mapping, Giuliano Mariani; Sergi Vidal-Sicart; Renato A. Va

Автор: Giuliano Mariani; Gianpiero Manca; Federica Orsini
Название: Atlas of Lymphoscintigraphy and Sentinel Node Mapping
ISBN: 8847039282 ISBN-13(EAN): 9788847039285
Издательство: Springer
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Цена: 158340.00 T
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Описание: This richly illustrated book covers lymphoscintigraphic mapping for radioguided sentinel node biopsy in cutaneous melanoma and cancers at a range of anatomic sites. Depicts commonly observed patterns and anatomic variants, and covers technical tips.

Автор: I. Taylor; Mohammad R.S. Keshtgar; P.C. Barneveld;
Название: The Sentinel Node in Surgical Oncology
ISBN: 3642642306 ISBN-13(EAN): 9783642642302
Издательство: Springer
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Цена: 46570.00 T
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Описание: In this volume an account is given of the technologies relevant to the detection of sentinel lymph nodes in the context of surgical oncology.

Автор: Ambrogio Pietro Londero, Serena Bertozzi, Carla Cedolini
Название: The Sentinel Lymph Node: Detection, Procedures and Clinical Implications
ISBN: 1536145572 ISBN-13(EAN): 9781536145571
Издательство: Nova Science
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Цена: 215410.00 T
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Описание: The Sentinel Lymph Node: Detection, Procedures and Clinical Implications gathers an overview of the sentinel lymph node biopsy procedure among different surgical settings (i.e., melanoma, breast, thyroid, vulva, endometrium, cervix, colon, anus, liver, gastric, urological and ovarian cancers). This book consists of eighteen chapters; the rationale and the purpose of this technique, which allows adequate lymph node staging while sparing patients from unnecessary complete lymph node dissections and the traditional harmful complications associated with them are discussed.Furthermore, this book outlines the technical aspects of the procedure (which are also accurately covered) from the various intraoperative sentinel node detection techniques to the subsequent sentinel lymph node analysis methods. Some new techniques for node detection, such as the Sentimag® technique (superparamagnetic iron oxide particles detected by a magneto-metric probe) and some new techniques for node analysis, such as the one-step nucleic acid amplification (OSNA), are accurately discussed. Finally, this book provides information also on preoperative lymph node diagnostics and sentinel lymph node biopsy perioperative complications in different nodal districts. In particular, the complications of sentinel node biopsy and for sentinel node dissection are accurately discussed with a particular focus on breast cancer, melanoma and gynecological cancers.

Название: Radiopharmaceuticals for Sentinel Lymph Node Detection: Status and Trends
ISBN: 920109714X ISBN-13(EAN): 9789201097149
Издательство: Mare Nostrum (Eurospan)
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Цена: 36030.00 T
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Описание: Summarizes the current status and future trends in the development of radiopharmaceuticals for sentinel lymph node detection (SLND), an essential diagnostic tool for the effective treatment of superficial cancers such as breast tumours and melanoma.

Автор: Stanley P. L. Leong
Название: Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer
ISBN: 1475776314 ISBN-13(EAN): 9781475776317
Издательство: Springer
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Цена: 93160.00 T
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Описание: The underlying thesis in solid tumor biology is that metastasis in general starts in an orderly progression with lymphatic spread first to the sentinel lymph node (SLN) in the nearest lymph node basin.

Автор: P.M. Schlag; Umberto Veronesi
Название: Lymphatic Metastasis and Sentinel Lymphonodectomy
ISBN: 3642630707 ISBN-13(EAN): 9783642630705
Издательство: Springer
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Цена: 46570.00 T
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Описание: The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in- creased morbidity versus eventual prognostic improvements by modification of therapy. An interesting concept which might im- prove diagnostic accuracy while reducing operative morbidity is the "sentinel node" technique.

Автор: Stanley P. L. Leong; Yuko Kitagawa; Masaki Kitajim
Название: Selective Sentinel Lymphadenectomy for Human Solid Cancer
ISBN: 1489988696 ISBN-13(EAN): 9781489988690
Издательство: Springer
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Описание:

In human solid cancer, the lymph node (LN) status is the most important prognostic indicator for the clinical outcome of patients. Recent developments in the sentinel lymph node (SLN) concept and technology have resulted in the application of this revolutionary approach to define the first draining or SLN to which the cancer may have metastasized. The underlying thesis in solid cancer biology is that metastasis generally starts in an orderly progression, spreading through the lymphatic channels to the SLN in the nearest LN basin. Thus, the logical approach is to harvest that specific SLN for thorough analysis. Because a tumorfree SLN is usually associated with a negative residual LN basin, a negative SLN is an excellent indication that micrometastasis has not occurred in the regional LNs. When the SLN is involved, it is unknown whether or not metastasis is limited only to the SLN or if the disease has spread to the remainder of the nodal basin. For this reason, if a SLN is positive, a complete lymph node dissection is recommended. Therefore, selective sentinel lymphadenectomy (SSL) should be considered as a staging procedure so that patients with negative SLNs (about 80%) may be spared an extensive LN dissection. Malignant melanoma has been proven to be the most ideal tumor model to study the role of SLN. Subsequently, SSL has been applied to breast cancer, colon cancer and other types of solid cancer. The multidisciplinary approach encompassing the surgeon, nuclear medicine physician, and pathologist is the key to such a successful procedure. Such a team can be formed readily with appropriate training. Beyond the technical aspects of harvesting the SLN, the implication of micrometastasis remains to be defined. Because the follow-up of melanoma and breast cancer patients after SSL is crucial, ongoing clinical trials are in progress to determine the biological and clinical significance of SLNs. Although the concept of SLN is viable in other types of cancer, such as gynecological and gastrointestinal, the technical aspects of the procedure need to be perfected and verified. The most exciting possibility of SSL is that it will lead to early diagnosis of micrometastasis in regional LNs. Early diagnosis makes it useful as a clinical staging procedure, and opens up new opportunities to study micrometastasis and its evolution within the SLNs. Examining the multifaceted aspects of micrometastasis, such as differentiation of different clones with respect to the primary tumor, acquisition of adhesion molecules, and host interaction with the microscopic tumor, will shed new light on the biology of early metastasis. New molecular and genetic tools may be used to dissect the mechanisms of lymphatic and hemo togenous routes of metastasis. If such mechanisms can be understood, new therapeutic advances may be developed to prevent the process of micrometastasis. Rather than targeting larger tumor burdens such as Stage IV disease, targeted adjuvant clinical trials can be developed for high risk patients following definit ive surgical resection. SSL is a standard staging procedure for patients with melanoma and is rapidly evolving into a standard procedure for breast cancer as well.