Docking Screens for Drug Discovery, Walter Filgueira de Azevedo Jr.
Автор: Li Название: The Drug Discovery Experience: Practices, Processes, and Perspectives ISBN: 0470942355 ISBN-13(EAN): 9780470942352 Издательство: Wiley Рейтинг: Цена: 82010.00 T Наличие на складе: Есть Описание: Edited by two distinguished chemists from academia and industry, this book presents an up-to-date overview of major aspects of drug discovery. It covers all ends of the discovery process from target selection to major therapeutic areas.
Автор: Caffrey Название: Parasitic Helminths: Targets, Screens, Drugs and Vaccines ISBN: 3527330593 ISBN-13(EAN): 9783527330591 Издательство: Wiley Рейтинг: Цена: 85710.00 T Наличие на складе: Есть Описание: The first title dealing with drug discovery against parasitic worms (Helminths) which include many of the major human and animal parasites. The book focusses on the development of novel drugs and vaccination strategies making it attractive for academia and industry alike.
Автор: Dastmalchi Siavoush, Hamzeh-Mivehroud Maryam, Sokouti Babak Название: Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery ISBN: 1522501150 ISBN-13(EAN): 9781522501152 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 267520.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: As the pharmaceutical industry continues to advance, new techniques in drug design are emerging. In order to deliver optimal care to patients, the development of innovative pharmacological techniques has become a widely studied topic.The Handbook of Research on Molecular Docking-Based Drug Design and Discovery investigates the evolution of pharmaceutical design and computational approaches in the field of molecular docking. Highlighting theoretical backgrounds and emergent research in the area of computer-assisted drug design, this publication is a pivotal source for professionals, researchers, medical chemists, pharmaceutical experts, and students interested in innovative practices and findings within the fields of computational chemistry and pharmaceutical sciences.
Автор: Dastmalchi Siavoush, Hamzeh-Mivehroud Maryam, Sokouti Babak Название: Applied Case Studies and Solutions in Molecular Docking-Based Drug Design ISBN: 1522503625 ISBN-13(EAN): 9781522503620 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 188100.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: As the pharmaceutical industry continues to advance, new techniques in drug design are emerging. In order to deliver optimum care to patients, the development of innovative pharmacological techniques has become a widely studied topic.Applied Case Studies and Solutions in Molecular Docking-Based Drug Design is a pivotal reference source for the latest scholarly research on the progress of pharmaceutical design and computational approaches in the field of molecular docking. Highlighting innovative research perspectives and real-world applications, this book is ideally designed for professionals, researchers, practitioners, and medical chemists actively involved in computational chemistry and pharmaceutical sciences.
Автор: S. Mohane Coumar Название: Molecular docking for computer-aided drug design ISBN: 012822312X ISBN-13(EAN): 9780128223123 Издательство: Elsevier Science Рейтинг: Цена: 107740.00 T Наличие на складе: Поставка под заказ. Описание: Collins Explore English is a 6-level course which provides full coverage of the Cambridge Primary English as a Second Language curriculum framework (0057) from 2020. With a magazine-style Student`s Resource Book, comprehensive Student`s Coursebook, and supportive Teacher`s Guide, it offers clear progression within and across levels.
Автор: Walter Filgueira de Azevedo Jr. Название: Docking Screens for Drug Discovery ISBN: 1493997513 ISBN-13(EAN): 9781493997510 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Поставка под заказ. Описание: This book focuses on recent developments in docking simulations for target proteins with chapters on specific techniques or applications for docking simulations, including the major docking programs.
Автор: Blass, Benjamin Название: Basic Principles Of Drug Discovery And Development ISBN: 0128172142 ISBN-13(EAN): 9780128172148 Издательство: Elsevier Science Рейтинг: Цена: 129130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics.
Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.
Название: High-Throughput Lead Optimization in Drug Discovery ISBN: 0367387719 ISBN-13(EAN): 9780367387716 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
A Single Source on Parallel Synthesis for Lead Optimization
The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high quality hits. More recently, the use of parallel synthesis techniques has shifted to applications beyond screening collections. Exploring the nuances of this technology, High-Throughput Lead Optimization in Drug Discovery describes the application of parallel synthesis to lead optimization and the design and synthesis of targeted libraries.
Examine Case Studies that Cover a Range of Different Biological Targets
Featuring real-world examples and contributions from well-known scientists, the book explores the shift to conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis. It includes more than 15 case studies that encompass a range of biological targets for application in different therapeutic areas. The text contains examples of solid and solution-phase techniques for the synthesis of directed libraries. The chapter authors explain the design principles they used to direct the choice of templates and diversity elements.
Speed Up Drug Discovery and the Hit-to-Lead Process
Focusing on the application of combinatorial chemistry to medicinal chemistry, this volume compiles a series of optimization projects that give you a snapshot of successes and challenges in the use of parallel synthesis for lead optimization. It explores how this technology, when applied to library design, can speed up drug discovery.
Автор: Littman Название: Translational Medicine and Drug Discovery ISBN: 0521886457 ISBN-13(EAN): 9780521886451 Издательство: Cambridge Academ Рейтинг: Цена: 91870.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry. It is essential for anyone interested in translational medicine from a variety of backgrounds: university institutes, medical schools, pharmaceutical companies and drug development researchers and decision-makers.
Автор: Patwardhan, Bhushan Название: Innovative Approaches in Drug Discovery ISBN: 0128018143 ISBN-13(EAN): 9780128018149 Издательство: Elsevier Science Рейтинг: Цена: 74100.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is nowfor a renewed commitment towards expanding the repertoire of medicines.a By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences.
Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned
Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines
Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery
Автор: Seetharama D. Satyanarayanajois Название: Drug Design and Discovery ISBN: 1493958240 ISBN-13(EAN): 9781493958245 Издательство: Springer Рейтинг: Цена: 107130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Research in the pharmaceutical sciences and medicinal chemistry has taken an important new direction in the past two decades with a focus on large molecules, especially peptides and proteins, as well as DNA therapeutics. In Drug Design and Discovery: Methods and Protocols, leading experts provide an in-depth view of key protocols that are commonly used in drug discovery laboratories. Covering both classic and cutting-edge techniques, this volume explores computational docking, quantitative structure-activity relationship (QSAR), peptide synthesis, labeling of peptides and proteins with fluorescent labels, DNA-microarray, zebrafish model for drug screening, and other analytical screening and biological assays that are routinely used during the drug discovery process. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and accessible, Drug Design and Discovery: Methods and Protocols serve as a vital laboratory reference for pharmaceutical chemists, medicinal chemists, and pharmacologists as well as for molecular biologists.
Автор: Gabriele Proetzel; Michael V. Wiles Название: Mouse Models for Drug Discovery ISBN: 149393659X ISBN-13(EAN): 9781493936595 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Herein, these models are appliedto a wide field of disease areas, including diabetes, cardiovascular disease,skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinaldisorders, as well as various behavioral models.
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