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Biomarkers for Alzheimer`s Disease Drug Development, Robert Perneczky
Robert Perneczky Biomarkers for Alzheimer`s Disease Drug Development 9781493992621

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Автор: Robert Perneczky
Название:  Biomarkers for Alzheimer`s Disease Drug Development
ISBN: 9781493992621
Издательство: Springer
Классификация:
Болезнь Альцгеймера и дименция

Фармакология

ISBN-10: 1493992627
Обложка/Формат: Soft cover
Страницы: 372
Вес: 0.74 кг.
Дата издания: 2018
Серия: Methods in Molecular Biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: 45 illustrations, color; 9 illustrations, black and white; xv, 372 p. 54 illus., 45 illus. in color.
Размер: 254 x 178
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biomarkers for Alzheimers Disease Drug Development aims to ensure successful results in the further study of this vital field.
Дополнительное описание: Epidemiology of Dementia: The Burden on Society, the Challenges for Research.- Population-based Approaches to Alzheimer’s Disease Prevention.- Systems Biology Methods for Alzheimer’s Disease Research towards Molecular Signatures, Subtypes and Stages and P


Advances in Cancer Biomarkers

Автор: Roberto Scatena
Название: Advances in Cancer Biomarkers
ISBN: 9402404201 ISBN-13(EAN): 9789402404203
Издательство: Springer
Рейтинг:
Цена: 156720.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

Prelims.- I Generality.- II Tumor markers-a critical revision.- Enzymes.- Hormones.- Oncofetal proteins.- Cytokeratins.- Carbohydrate markers.- Blood group antigens.- Genetic markers.- Various protein markers.- III Perspectives.- The role of Circulating tumor Cells as tumor markers.- Index.


Biomarkers for Alzheimer`s Disease Drug Development

Автор: Perneczky
Название: Biomarkers for Alzheimer`s Disease Drug Development
ISBN: 1493977032 ISBN-13(EAN): 9781493977031
Издательство: Springer
Рейтинг:
Цена: 74530.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

PART I: The need for Alzheimer's Disease Biomarkers

1. Epidemiology of Dementia: The Burden on Society, the Challenges for Research

Frank J. Wolters and M. Arfan Ikram

2. Population-based Approaches to Alzheimer's Disease Prevention

Robert Perneczky

3. Systems Biology Methods for Alzheimer's Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials

Juan I. Castrillo, Simone Lista, Harald Hampel, and Craig W. Ritchie

PART II: Innovative Approaches to Cerebrospinal Fluid Biomarker Discovery

4. CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform

Paul L. Wood and Randall L. Woltjer

5. CSF N-glycomics using MALDI MS Techniques in Alzheimer's Disease

Angelo Palmigiano, Angela Messina, Rosaria Ornella Bua, Rita Barone, Luisa Sturiale, Mario Zappia, and Domenico Garozzo

6. MicroRNA Profiling of Alzheimer's Disease Cerebrospinal Fluid Johannes Denk and Holger Jahn

Part III: Novel Blood-based Biomarkers

7. Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-β in Human Blood Plasma

Jonathan Vogelgsang, Jens Wiltfang, and Hans-W. Klafki

8. Mass Spectrometry-based Metabolomic Multiplatform for Alzheimer's Disease Research

Raъl Gonzбlez-Domнnguez, Бlvaro Gonzбlez-Domнnguez, Ana Sayago, and Бngeles Fernбndez-Recamales

9. Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases

Filippo Baldacci, Simone Lista, Sid E. O'Bryant, Roberto Ceravolo, Nicola Toschi, and Harald Hampel,

Part IV: Magnetic Resonance Imaging Methods

10. Functional Magnetic Resonance Imaging in Alzheimer' Disease Drug Development

Stefan Holiga, Ahmed Abdulkadir, Stefan Klцppel, and Juergen Dukart

11. Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies

Carles Falcon, Grйgory Operto, Josй Luis Molinuevo, and Juan Domingo Gispert

12. Hybrid PET-MRI in Alzheimer's Disease Research

Ismini C. Mainta, Maria I. Vargas, Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto

Part V: Molecular Imaging Approaches

13. Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers

Silvia Morbelli and Matteo Bauckneht

14. The use of 18F-FDG PET in the Diagnostic Workup of Alzheimer's Dementia

Marion M. Ortner

15. Quantification of Tau Load in Alzheimer's Disease Clinical Trials Using Positron Emission Tomography

Tessa Timmers, Bart N.M. van Berckel, Adriaan Lammertsma, and Rik Ossenkoppele

16. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach

Elena Rodriguez-Vieitez and Agneta Nordberg

Part VI: Neuropathology

17. Unbiased Lipidomics and Metabolomics of Human Brain Samples

Giuseppe Astarita, Matteo Stocchero, and Giuseppe Paglia

18. Neuropathological Assessment as an Endpoint in Clinical Trial Design

Steve Gentleman and Alan King Lun Liu

Part VII Genomic Methods

19. Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer's Disease Biomarker Discovery

Petros Takousis

20. Telomere length shortening in Alzheimer's disease - procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study
Yiqiang Zhan,

Biomarkers for Preclinical Alzheimer`s Disease

Автор: Robert Perneczky
Название: Biomarkers for Preclinical Alzheimer`s Disease
ISBN: 1493992554 ISBN-13(EAN): 9781493992553
Издательство: Springer
Рейтинг:
Цена: 88500.00 T
Наличие на складе: Поставка под заказ.
Описание: This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer’s disease (AD). The chapters in this book are separated into five parts. Part one explores the reasons why we need improved approaches for early detection and diagnosis of AD. Part two describes clinical and research techniques for preclinical AD diagnosis. Part three looks at the current methods in use to diagnose AD and how they can also be used for early detection in healthy older individuals. Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Comprehensive and cutting-edge, Biomarkers for Preclinical Alzheimer’s Disease is a valuable resource for individuals interested in the use of biomarker strategies to improve early AD detection. This book will be of great interest to researchers and clinicians from both academia and industry.”



Biomarkers for Preclinical Alzheimer`s Disease

Автор: Perneczky
Название: Biomarkers for Preclinical Alzheimer`s Disease
ISBN: 1493976737 ISBN-13(EAN): 9781493976737
Издательство: Springer
Рейтинг:
Цена: 65210.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer`s disease (AD). Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research.

New Advances on Disease Biomarkers and Molecular Targets in Biomedicine

Автор: Nikki P. Lee; C.Y. Cheng; John M. Luk
Название: New Advances on Disease Biomarkers and Molecular Targets in Biomedicine
ISBN: 1627039015 ISBN-13(EAN): 9781627039017
Издательство: Springer
Рейтинг:
Цена: 148010.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes current research on disease biomarkers, including oncofetal molecules in cancer prediction and treatment, evolving development in cancer biology at the cellular and molecular levels and understanding of new classes of molecules in diseases.

Novel Biomarkers for Heart Disease

Название: Novel Biomarkers for Heart Disease
ISBN: 3039438832 ISBN-13(EAN): 9783039438839
Издательство: Неизвестно
Рейтинг:
Цена: 96130.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

Cardiac biomarkers such as troponins and natiuretic peptides have made a great impact on clinical decision making as well as improving our understanding of molecular mechanisms of different disease conditions. However, the biomarkers that are currently in use do not reflect all the multiple disease pathways that are involved in a broad spectrum of cardiac disease conditions ranging from acute coronary syndrome, to heart failure (and heart failure with preserved ejection fraction, HFpEF), to pulmonary hypertension or arrhythmias. In this Special Issue, we will provide an overview of the current developments in the field of biomarker research, beginning with research on molecular pathways and cellular communication (e.g., microRNA) up to the clinical use of biomarkers.


Encyclopedia of Drug Discovery and Development: Volume II (Tools, Methods, Biomarkers and Drug Discovery)

Автор: Burnett Ned
Название: Encyclopedia of Drug Discovery and Development: Volume II (Tools, Methods, Biomarkers and Drug Discovery)
ISBN: 1632421372 ISBN-13(EAN): 9781632421371
Издательство: Неизвестно
Цена: 159860.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.

Biomarkers, Diagnostics and Precision Medicine in the Drug Industry

Автор: Halim, Abdel
Название: Biomarkers, Diagnostics and Precision Medicine in the Drug Industry
ISBN: 0128161213 ISBN-13(EAN): 9780128161210
Издательство: Elsevier Science
Рейтинг:
Цена: 132500.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

The high failure rate in the pharmaceutical industry has positioned biomarkers and personalized medicine in the frontline as possible solutions. If executed right, biomarkers and companion diagnostics (CDx) can potentially help the drug industry enhance the probability of success, accelerating time to market, and, more importantly, benefit patients by supporting accurate diagnosis and selection of the most effective and least toxic therapies. Biomarkers, Diagnostics, and Precision Medicine in the Drug Industry aims to examine the challenges and limitations in biomarkers and laboratory tests. It also offers advice on best practices to ensure proper application of biomarkers and bridges the gap between diagnostic business development claims and real-life deliverables. The book covers biomarkers for different purposes, provides examples from different technologies which includes standard-of-care approved assays as well as for-investigational-use and for-research-use-only assays. It also includes new data for biomarkers in different therapeutic indications and offers case studies and practical examples. Biomarkers, Diagnostics, and Precision Medicine in the Drug Industry serves as a reference to drug developers, IVD providers, healthcare givers, academics, and researchers for best practices to help increase the probability of success.

  • Provides the unique insight of an expert with extensive experience in diagnostics and clinical laboratory on one side and drug discovery and development on the other side
  • Addresses the challenges of drug development and precision medicine and suggests how to eliminate or mitigate these challenges through better utilization of biomarkers and diagnostics in drug development and patient management
  • Features case studies and real-life examples from different classes of biomarkers on different platforms for different therapeutic areas

Technical Aspects of Toxicological Immunohistochemistry: System Specific Biomarkers

Автор: Aziz Syed a., Mehta Rekha
Название: Technical Aspects of Toxicological Immunohistochemistry: System Specific Biomarkers
ISBN: 1493979655 ISBN-13(EAN): 9781493979653
Издательство: Springer
Рейтинг:
Цена: 93160.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues.

Biomarkers in Drug Discovery and Disease Diagnosis

Автор: Lambert Holly
Название: Biomarkers in Drug Discovery and Disease Diagnosis
ISBN: 1632428350 ISBN-13(EAN): 9781632428356
Издательство: Неизвестно
Рейтинг:
Цена: 155570.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.

Toxicologic Biomarkers

Название: Toxicologic Biomarkers
ISBN: 0367453703 ISBN-13(EAN): 9780367453701
Издательство: Taylor&Francis
Рейтинг:
Цена: 63280.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Responding to the explosion of advances in the use of biomarkers to efficiently, rapidly, and economically evaluate the health effects of chemical entities, this authoritative reference provides a detailed overview of the theory, development, and practical application of biomarkers in the toxicological, environmental, forensic, and pharmaceutical s

Immunotherapy and Biomarkers in Neurodegenerative Disorders

Автор: Martin Ingelsson; Lars Lannfelt
Название: Immunotherapy and Biomarkers in Neurodegenerative Disorders
ISBN: 1493980785 ISBN-13(EAN): 9781493980789
Издательство: Springer
Рейтинг:
Цена: 102480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With a focus on Alzheimer`s disease, the firstsections of the book examine immunotherapeutic approaches for theaforementioned disease as well as for Parkinson`s disease and Huntington`s disease,amongst others.
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