Histamine and Histamine Receptors in Health and Disease, Yuichi Hattori; Roland Seifert

Автор: Fridman
Название: Discoidin Domain Receptors in Health and Disease
ISBN: 1493963813 ISBN-13(EAN): 9781493963812
Издательство: Springer
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Цена: 156720.00 T
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Описание: The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Автор: B?rje Uvn?s
Название: Histamine and Histamine Antagonists
ISBN: 3642758428 ISBN-13(EAN): 9783642758423
Издательство: Springer
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Цена: 113190.00 T
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Описание: With contributions by numerous experts

Автор: Ekaterini Tiligada; Madeleine Ennis
Название: Histamine Receptors as Drug Targets
ISBN: 1493968416 ISBN-13(EAN): 9781493968411
Издательство: Springer
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Цена: 186330.00 T
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Описание:

1. Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors

Автор: Blandina
Название: Histamine Receptors
ISBN: 3319403060 ISBN-13(EAN): 9783319403069
Издательство: Springer
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Цена: 156720.00 T
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Описание: A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.

Автор: Blandina Patrizio, Passani Maria Beatrice
Название: Histamine Receptors: Preclinical and Clinical Aspects
ISBN: 3319820745 ISBN-13(EAN): 9783319820743
Издательство: Springer
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Цена: 139750.00 T
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Описание: A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors.

Название: Histamine receptors as drug targets
ISBN: 1493983156 ISBN-13(EAN): 9781493983155
Издательство: Springer
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Цена: 102480.00 T
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Описание:

1. Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors

Автор: Kenji Tasaka
Название: New Advances in Histamine Research
ISBN: 4431682651 ISBN-13(EAN): 9784431682653
Издательство: Springer
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Цена: 81050.00 T
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Описание: Recent research has given great insight into the physiological and pharmaceutical effects of histamine on the central nervous system and especially on the brain. Also featured are the mechanisms of histamine release in bone marrow and mast cells and the role of histamine in neutrophil differentiation.

Автор: Jarisch Reinhart
Название: Histamine Intolerance: Histamine and Seasickness
ISBN: 3642554466 ISBN-13(EAN): 9783642554469
Издательство: Springer
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Цена: 74530.00 T
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Описание: Histamine is an important mediator of allergic diseases, but knowledge of histamine as a cause of numerous non-allergic symptoms and signs is limited. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages and intolerance to red wine. Diagnosis of histamine intolerance is explained and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the relation of histamine to a wide variety of conditions, including drug intolerance, atopic dermatitis, seasickness and osteoporosis. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance and by assisting in the selection of therapeutic measures.

Автор: Reinhart Jarisch
Название: Histamine Intolerance
ISBN: 3662513307 ISBN-13(EAN): 9783662513309
Издательство: Springer
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Цена: 53100.00 T
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Описание: Histamine is an important mediator of allergic diseases, but knowledge of histamine as a cause of numerous non-allergic symptoms and signs is limited. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages and intolerance to red wine. Diagnosis of histamine intolerance is explained and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the relation of histamine to a wide variety of conditions, including drug intolerance, atopic dermatitis, seasickness and osteoporosis. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance and by assisting in the selection of therapeutic measures.

Автор: H. Timmermann
Название: New Perspectives in Histamine Research
ISBN: 3034873115 ISBN-13(EAN): 9783034873116
Издательство: Springer
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Цена: 46570.00 T
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Описание: The role of histamine as a neurotransmitter, the existence of a presynaptic receptor (H ) controlling the release of histamine 3 and other neurotransmitters, and the particular character of this receptor became important as the possibilities to design new therapeutic agents were realized.

Название: The Third Histamine Receptor
ISBN: 0367452510 ISBN-13(EAN): 9780367452513
Издательство: Taylor&Francis
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Цена: 63280.00 T
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Описание: Since their discovery, the potential of histamine H3 receptor ligands in various CNS disorders have received much attention. This resource presents recent advances with an emphasis on pharmacology. It covers identification and localization of receptors and the development of novel ligands incorporating pre-clinical and clinical studie

Автор: Giraldo, Jesus
Название: Oligomerization In Health And Disease: From Enzymes To G Protein-Coupled Receptors,169
ISBN: 0128179295 ISBN-13(EAN): 9780128179291
Издательство: Elsevier Science
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Цена: 140360.00 T
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Описание:

Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scientific importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine β-synthase, and Oligomerization of Porphobilinogen Synthase.