The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee, Second Edition, Petrie Whitney Kayla, Wallace Sonja Lea

This new edition of a bestseller contains new information on international regulations regarding animal subject research and the requirements for an ethics panel review. It discusses outside collaborations, interinstitutional memorandums of understanding, and the differences in regulations between countries. The book also includes a new chapter exploring semiannual program reviews, semiannual inspections, and postapproval monitoring. The contributors provide updated information on the protocol submission process, electronic protocol management systems, and records management--including the essential elements of the protocol form and how to complete it.

The book also delves deeply into bioethics. It discusses how IACUCs can ensure that each proposal to use animals in research includes an ethical review with a harm-benefit analysis weighing the expected advancements in human and animal health against the potential harm inflicted to the animal. Also included is a chapter on how to survive a regulatory inspection or an accreditation site visit.

All interpretations of the regulations have been reviewed by staff at the NIH Office of Laboratory Animal Welfare (OLAW), the Animal Welfare Information Center (AWIC), and USDA APHIS/Animal Care (AC) for consistency and compliance with the PHS Policy and the USDA Animal Welfare Act Regulations (AWAR).

• Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals.
• Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee.
• Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more.
• Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia.
• Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs.

The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.