DNA and Histone Methylation as Cancer Targets, Kaneda Atsushi, Tsukada Yu-Ichi

Автор: Eric Verdin
Название: Histone Deacetylases
ISBN: 1617376027 ISBN-13(EAN): 9781617376023
Издательство: Springer
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Цена: 231990.00 T
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Описание: A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression.

Автор: Atsushi Kaneda; Yu-ichi Tsukada
Название: DNA and Histone Methylation as Cancer Targets
ISBN: 3319597841 ISBN-13(EAN): 9783319597843
Издательство: Springer
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Цена: 186330.00 T
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This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Автор: P.A. Jones; P.K. Vogt
Название: DNA Methylation and Cancer
ISBN: 3642640907 ISBN-13(EAN): 9783642640902
Издательство: Springer
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Цена: 113190.00 T
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Описание: This book is a comprehensive survey of new and exciting developments regarding the role of DNA methylation in human cancer.

Автор: Moshe Szyf
Название: DNA Methylation and Cancer Therapy
ISBN: 1441934162 ISBN-13(EAN): 9781441934161
Издательство: Springer
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Цена: 213360.00 T
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Описание: Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation.

Автор: Manel Esteller
Название: DNA Methylation, Epigenetics and Metastasis
ISBN: 9048169178 ISBN-13(EAN): 9789048169177
Издательство: Springer
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Цена: 231990.00 T
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Автор: Kohji Hasunuma
Название: Quantum Biology: Methods to Cure Malignant Cancerous Cells into Cells with Reduced CpG Methylation Accessible to Eating Cell Systems
ISBN: 1536147753 ISBN-13(EAN): 9781536147759
Издательство: Nova Science
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Цена: 77080.00 T
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Описание: The 3O2 generated by the photolysis process will accept enough energy from triplet-chlorophyll to provide the energy states of a singlet of oxygen (1O2), 1Δg, and 1Σg+, with emissions in the range of 200 500 m. The 1O2 would react with unsaturated fatty acids to form malondialdehyde (MDA).In humans, the methylation of CpG islands in cancerous cells is so high that the sensing ability of the occurrence of environmental changes to genes with CpG islands could be insufficient for genes with CpG islands. House-keeping genes function independently by sensing various types of information from neighboring cells, and supporting the proliferation of cells behaving as cancerous cells so that the cells achieve a malignant, metastatic state. The CpG island-controlled genes (47,000/human haploid genome) and CpG island-independent genes (33,000/human haploid genome) co-regulate in the normal cell systems.FAD, FMN, riboflavin, and derivatives of heme groups are well known as photosensitizers, which emit 1O2 with ROS in the solution in vivo. In sunlight, photosensitizers will function as the generators of 1O2 and ROS. During the daytime, there is a plentiful supply of 1O2 and ROS from the sunlight, and which inevitably constitutes the circadian rhythms of ROS. The repeated evolution of 1O2 and ROS would function to stimulate the methylation of CpG islands.The tubulin structures, extending from the plasma membrane to two centrosomes and located along the sides of the nucleus, are designated as asters. In darkness, the protein complex of NDPK-1/catalase is located in the plasma membrane. However, upon receiving light illumination, the NDPK-1/catalase function captures 1O2 using catalase. The NDPK-1 binds NADH and supplies electrons to bind 1O2 that is bound to the catalase, resulting in the release of a super oxide (O2.-). The NDPK/catalase protein complex located in the plasma membrane moves along the aster-forming tubulin structure to the cytosol. As a result, the nucleus is protected from 1O2 by the wall, which is composed of the NDPK-1/catalase complex.

Автор: Yu Buwei, Zhang Jiaqiang, Zeng Yiming
Название: Single-Cell Sequencing and Methylation: Methods and Clinical Applications
ISBN: 981154493X ISBN-13(EAN): 9789811544934
Издательство: Springer
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Цена: 139750.00 T
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Описание: With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers.

Автор: Fang Dong, Han Junhong
Название: Histone Mutations and Cancer
ISBN: 9811581037 ISBN-13(EAN): 9789811581038
Издательство: Springer
Цена: 93160.00 T
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Описание: This book focuses on histone mutations, especially those mutations closely related to cancer.

Автор: Ganai Shabir Ahmad
Название: Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy
ISBN: 9811581789 ISBN-13(EAN): 9789811581786
Издательство: Springer
Цена: 139750.00 T
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Описание: This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy.

Автор: Shelley L. Berger; O. Nakanishi; Bernhard Haendler
Название: The Histone Code and Beyond
ISBN: 364242175X ISBN-13(EAN): 9783642421754
Издательство: Springer
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Цена: 130430.00 T
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Описание: Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin.