Heat Shock Protein Inhibitors: Success Stories, McAlpine Shelli R., Edkins Adrienne Lesley

Автор: D. Vazquez
Название: Inhibitors of Protein Biosynthesis
ISBN: 3642813119 ISBN-13(EAN): 9783642813115
Издательство: Springer
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Цена: 121110.00 T
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Автор: McAlpine
Название: Heat Shock Protein Inhibitors
ISBN: 3319326058 ISBN-13(EAN): 9783319326054
Издательство: Springer
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Цена: 243800.00 T
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Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Автор: Tavassoli Ali
Название: Inhibitors of Protein-Protein Interactions: Small Molecules, Cyclic Peptides, Macrocycles and Antibodies
ISBN: 178801569X ISBN-13(EAN): 9781788015691
Издательство: Royal Society of Chemistry
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Цена: 223870.00 T
Наличие на складе: Нет в наличии.
Описание: Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.

Автор: Beverly D Carson
Название: Histone Deacetylase Inhibitors (HDIs): Pharmacology, Uses & Health Effects
ISBN: 1634638352 ISBN-13(EAN): 9781634638357
Издательство: Nova Science
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Цена: 168950.00 T
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Описание: Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyse the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.

Автор: Peter K. Vogt; Stephen I. Reed
Название: Cyclin Dependent Kinase (CDK) Inhibitors
ISBN: 3642719430 ISBN-13(EAN): 9783642719431
Издательство: Springer
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Цена: 121110.00 T
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Описание: More than 10 years ago, the discovery of cyclin-dependent ki- nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control.

Автор: Supuran Claudiu T., Capasso Clemente
Название: Zinc Enzyme Inhibitors: Enzymes from Microorganisms
ISBN: 3319834444 ISBN-13(EAN): 9783319834443
Издательство: Springer
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Цена: 214280.00 T
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Описание: An Elusive Task: A Clinically Useful Inhibitor of Metallo-β-Lactamases.- Inhibitors of Histidinol Dehydrogenase.- Botulinum Neurotoxin, Tetanus Toxin, and Anthrax Lethal Factor Countermeasures.- Inhibition and Activity Regulation of Bacterial Collagenases.- Fungal Carbonic Anhydrases and Their Inhibition.- Protozoan Carbonic Anhydrases.- Bacterial Carbonic Anhydrases.

Автор: Michael B Bottorff; William E. Evans; Ingrid Hille
Название: Drug Concentration Monitoring Microbial Alpha-Glucosidase Inhibitors Plasminogen Activators
ISBN: 3642734634 ISBN-13(EAN): 9783642734632
Издательство: Springer
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Цена: 121110.00 T
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Описание: Das Buch enthalt Kapitel uber: M. B. Bottorff, W. E. Evans, Memphis, TN, USA: Uberwachung der Medikament-KonzentrationE. Truscheit, I. Hillebrand, B. Junge, L. Muller, W. Puls, D. D. Schmidt, Wuppertal, FRG: Inhibitoren der mikrobiellen alpha-Glucosidase: Chemie, Biochemie und potentielle therapeutische AnwendungenH. Will, Berlin-Buch, GDR: Plasminogen-Aktivatoren: Molekuleigenschaften, biologische Zellfunktion und klinische Anwendung

Автор: Martin Lorenz Stein
Название: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens
ISBN: 331938399X ISBN-13(EAN): 9783319383996
Издательство: Springer
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Цена: 87060.00 T
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Описание: Martin Stein`s thesis describes a novel methodology for natural product discovery. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens.

Автор: Shabir Ahmad Ganai
Название: Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders
ISBN: 981138018X ISBN-13(EAN): 9789811380181
Издательство: Springer
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Цена: 130430.00 T
Наличие на складе: Поставка под заказ.
Описание: This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors’ therapeutic efficacy against various neurological complications.

Автор: Alvaro Macieira-Coelho
Название: Inhibitors of Cell Growth
ISBN: 3642721516 ISBN-13(EAN): 9783642721519
Издательство: Springer
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Цена: 46570.00 T
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Автор: Lorenzo A. Pinna; Patricia T.W. Cohen
Название: Inhibitors of Protein Kinases and Protein Phosphates
ISBN: 3642422063 ISBN-13(EAN): 9783642422065
Издательство: Springer
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Цена: 465840.00 T
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Описание: The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases. This goal is attained by contributions of leader investigators in the field, who address the issue from different angles.

Автор: Goran Claeson; Michael F. Scully; Vijay V. Kakkar;
Название: The Design of Synthetic Inhibitors of Thrombin
ISBN: 1489924205 ISBN-13(EAN): 9781489924209
Издательство: Springer
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Цена: 139750.00 T
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Описание: The symposium was organized in four sessions: (1) Structural features of the interaction of thrombin with substrates and inhibitors, (2) Synthetic inhibitors, (3) Hirudin and its analogues, and (4) Pharmacological and clinical considerations.