Applications of Mass Spectrometry in Microbiology: From Strain Characterization to Rapid Screening for Antibiotic Resistance, Demirev Plamen, Sandrin Todd R.

Название: Antibiotic Drug Discovery: New Targets and Molecular Entities
ISBN: 1782624244 ISBN-13(EAN): 9781782624240
Издательство: Royal Society of Chemistry
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Цена: 237950.00 T
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Описание: This book identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities.

Название: Characterization of protein therapeutics using mass spectrometry
ISBN: 1489973648 ISBN-13(EAN): 9781489973641
Издательство: Springer
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Цена: 121110.00 T
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Описание: This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.

Автор: Kon, Kateryna
Название: Antibiotic Resistance
ISBN: 0128036427 ISBN-13(EAN): 9780128036426
Издательство: Elsevier Science
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Цена: 123520.00 T
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Описание: "

Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches" discusses up-to-date knowledge in mechanisms of antibiotic resistance and all recent advances in fighting microbial resistance such as the applications of nanotechnology, plant products, bacteriophages, marine products, algae, insect-derived products, and other alternative methods that can be applied to fight bacterial infections.

Understanding fundamental mechanisms of antibiotic resistance is a key step in the discovery of effective methods to cope with resistance. This book also discusses methods used to fight antibiotic-resistant infection based on a deep understanding of the mechanisms involved in the development of the resistance.
Discusses methods used to fight antibiotic-resistant infection based on a deep understanding of mechanisms involved in the development of the resistanceProvides information on modern methods used to fight antibiotic resistanceCovers a wide range of alternative methods to fight bacterial resistance, offering the most complete information availableDiscusses both newly emerging trends and traditionally applied methods to fight antibiotic resistant infections in light of recent scientific developmentsOffers the most up-to-date information in fighting antibiotic resistanceIncludes involvement of contributors all across the world, presenting questions of interest to readers of both developed and developing countries

Автор: Podolsky, Scott H
Название: The antibiotic Era: Reform, Resistance, and the Pursuit of a Rational Therapeutics
ISBN: 1421415933 ISBN-13(EAN): 9781421415932
Издательство: Johns Hopkins University Press
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Цена: 22280.00 T
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Описание: Only by understanding the historical forces that have shaped our current situation, Podolsky argues, can we properly understand and frame our choices moving forward.

Автор: Rufus Finley, Marcos Solomon
Название: Antibiotic Resistance: Analysis & Monitoring Efforts
ISBN: 1619424169 ISBN-13(EAN): 9781619424166
Издательство: Nova Science
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Цена: 168950.00 T
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Описание: Infections that were once treatable have become more difficult to treat because of antibiotic resistance. Antibiotics have saved millions of lives, but antibiotic use in food animals contributes to the emergence of resistant bacteria that may affect humans. This book presents the risk assessment and monitoring efforts of antibiotic resistance.

Автор: Elijah Poole
Название: Combating Antibiotic Resistance: Report to the President National Strategy
ISBN: 1634634322 ISBN-13(EAN): 9781634634328
Издательство: Nova Science
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Цена: 173170.00 T
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Описание: For an American in the 21st century, it is hard to imagine the world before antibiotics. At the beginning of the 20th century, as many as nine women out of every 1,000 who gave birth died, 40 percent from sepsis. In some cities as many as 30 percent of children died before their first birthday. One of every nine people who developed a serious skin infection died, even from something as simple as a scrape or an insect bite. Pneumonia killed 30 percent of those who contracted it; meningitis killed 70 percent. Ear infections caused deafness; sore throats were not infrequently followed by rheumatic fever and heart failure. Surgical procedures were associated with high morbidity and mortality due to infection. This picture changed dramatically with three major developments: improvements in public health, vaccines, and antibiotics. Over the course of the 20th century, deaths from infectious diseases declined markedly and contributed to a substantial increase in life expectancy. Antibiotics, in particular, have saved millions of lives. This book discusses combating antibiotic resistance and provides reports to the presidents and national strategies.

Автор: Anthony R.M. Coates
Название: Antibiotic Resistance
ISBN: 3642432492 ISBN-13(EAN): 9783642432491
Издательство: Springer
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Цена: 372670.00 T
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Описание: This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.

Автор: Schiesser, William E.
Название: Ode/Pde Analysis Of Antibiotic/Antimicrobial Resistance
ISBN: 0128240024 ISBN-13(EAN): 9780128240021
Издательство: Elsevier Science
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Цена: 149340.00 T
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Автор: Manaia Cйlia M., Donner Erica, Vaz-Moreira Ivone
Название: Antibiotic Resistance in the Environment: A Worldwide Overview
ISBN: 3030550648 ISBN-13(EAN): 9783030550646
Издательство: Springer
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Цена: 354040.00 T
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Описание: This book provides a multidisciplinary review of antibiotic resistance and unravels the complex and interrelated roles of environmental sources, including pharmaceutical industry effluents, hospital and domestic effluents, wildlife and drinking water. Antibiotic resistance is a global public health issue in which the interface between humans, animals and the environment is particularly relevant. The contrasts seen across different environmental compartments and world regions, which are due to climate, social and policy differences, mean that this problem needs to be analyzed from a multi-geographic and multi-cultural angle. Bringing together contributions from researchers on different continents with expertise in antibiotic resistance in a range of different environmental compartments, the book offers a detailed reflection on the paths that make antibiotic resistance a global threat, and the state-of- the-art in antibiotic resistance surveillance and risk assessment in complex environmental matrices.

Автор: Goran Odham
Название: Gas Chromatography Mass Spectrometry Applications in Microbiology
ISBN: 1468445286 ISBN-13(EAN): 9781468445282
Издательство: Springer
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Цена: 46570.00 T
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Описание: During recent years there has been increasing interest in the value of a number of chemical and physical-chemical analytical methods for the detection and characterization of microorganisms. Furthermore, such methods are currently used in studies on microbial metabolic processes, on the role of microorganisms in the turnover of inorganic and organic compounds, and on the impact on environmental changes by microbial activity. Moreover, the introduction of some of these methods not only shortens the analytical time period compared to ·'traditional" techniques, but also improves the analytical quality. Mass spectrometry (MS) combined with chromatographic inlet systems, particularly gas chromatography (GC), belongs to those methods which during recent years have established their value for the above-mentioned purposes. The present volume starts with basic chapters on the principles for MS and common inlet systems, particulary Gc. It discusses applications of these techniques to a number of microbiological disciplines, e.g., ecologi­ cal and medical microbiology. Emphasis is laid on organic compound classes vii viii / PREFACE of special relevance to microbiology, e.g., volatiles, lipids, amino acids, peptides and carbohydrates. Some compound classes of a more general biochemical rather than specific microbiological importance, e.g., steroids and nucleotides, are dealt with briefly. The editors wish to thank all those who have contributed to this book. We hope it will stimulate further research in this futuristic field and will be of practical value.

Автор: Demirev, Plamen, Sandrin, Todd R. (Eds.
Название: Applications of Mass Spectrometry in Microbiology
ISBN: 3319260685 ISBN-13(EAN): 9783319260686
Издательство: Springer
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Цена: 121890.00 T
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Описание: As of mid-2015, more than 3300 commercial MS systems for microorganism identification have been deployed worldwide in hospitals and clinical labs. While previous work has covered broader approaches in using MS to characterize microorganisms at the species level or above, this book focuses on strain-level and subtyping applications.