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Neurodegenerative Disorders as Systemic Diseases, Wada Keiji


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Автор: Wada Keiji
Название:  Neurodegenerative Disorders as Systemic Diseases
ISBN: 9784431562986
Издательство: Springer
Классификация:


ISBN-10: 4431562982
Обложка/Формат: Paperback
Страницы: 304
Вес: 0.44 кг.
Дата издания: 23.08.2016
Язык: English
Издание: Softcover reprint of
Иллюстрации: 7 tables, black and white; viii, 304 p.; 7 tables, black and white; viii, 304 p.
Размер: 23.39 x 15.60 x 1.68 cm
Читательская аудитория: General (us: trade)
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.
Дополнительное описание: PART I A NEW CONCEPT OF NEURODEGENERATION IN BIOLOGY AND PATHOPHYSIOLOGY.- 1 Conformational disease and RNA disease theory in the context of neurodegenerative diseases.- 2 Brain-peripheral organ communication.- 3 The brain-immune network in spinal cord in


Mitochondrial Dysfunction in Neurodegenerative Disorders

Автор: Reeve
Название: Mitochondrial Dysfunction in Neurodegenerative Disorders
ISBN: 3319286358 ISBN-13(EAN): 9783319286358
Издательство: Springer
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Цена: 125770.00 T
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Описание: This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson’s disease, Alzheimer’s disease and multiplesclerosis. The reader is guided through the basic functions of mitochondria andthe mechanisms that lead to their dysfunction, and on to the consequences ofthis dysfunction for neuronal function before finishing with the modelling ofthese disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflectadvances in the field and there are many new contributors and topics, includinghow mitochondria are degraded and the interaction of the mitochondria withpathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disordersprovides an accessible, authoritative guide to this important area forneurologists; research and clinical neuroscientists; neuropathologists; andresidents with an interest in clinical research.

Quality Control of Cellular Protein in Neurodegenerative Disorders

Автор: Md. Sahab Uddin, Ghulam Md Ashraf
Название: Quality Control of Cellular Protein in Neurodegenerative Disorders
ISBN: 1799813177 ISBN-13(EAN): 9781799813170
Издательство: Mare Nostrum (Eurospan)
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Цена: 264270.00 T
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Описание: A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity. Though multiple factors like aging, oxidative stress, gene inconsistency, etc. are responsible for the dysfunction of the protein quality control system, targeting protein quality control has become an auspicious approach to block the propagation of neurodegeneration.

Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the theoretical and practical methods of protein quality control systems and potential therapeutic approaches to halt the development and propagation of neurodegenerative disorders. Featuring coverage on a broad range of topics such as cellular chaperones, protein folding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.

Multimodal Neuroimaging Computing for the Characterization of Neurodegenerative Disorders

Автор: Sidong Liu
Название: Multimodal Neuroimaging Computing for the Characterization of Neurodegenerative Disorders
ISBN: 9811035326 ISBN-13(EAN): 9789811035326
Издательство: Springer
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Цена: 102480.00 T
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Описание: This thesis covers various facets of brain image computing methods and illustrates the scientific understanding of neurodegenerative disorders based on four general aspects of multimodal neuroimaging computing: neuroimaging data pre-processing, brain feature modeling, pathological pattern analysis, and translational model development.

Immunization Against Alzheimer`s Disease and Other Neurodegenerative Disorders

Автор: Dennis J. Selkoe
Название: Immunization Against Alzheimer`s Disease and Other Neurodegenerative Disorders
ISBN: 3642639372 ISBN-13(EAN): 9783642639371
Издательство: Springer
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Цена: 121110.00 T
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Описание: Promising effects in mice of immunization by ss-amyloid stimulated substantial research efforts and high hopes.

Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders

Автор: V.M.-Y. Lee; J.Q. Trojanowski; L. Buee; Y. Christe
Название: Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders
ISBN: 3642086497 ISBN-13(EAN): 9783642086496
Издательство: Springer
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Цена: 222670.00 T
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Описание: In this volume are contributions based on a meeting arranged by the WHO and the Fondation IPSEN. The scientists focus on neurodegenerative disorders like Alzheimer`s Disease, Chromosome 17-Linked Dementia, Parkinson`s Disease and disorders with tauopathies.

Neurodegenerative Disorders

Автор: Orla Hardiman; Colin P. Doherty; Marwa Elamin; Pet
Название: Neurodegenerative Disorders
ISBN: 3319794698 ISBN-13(EAN): 9783319794693
Издательство: Springer
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Цена: 53100.00 T
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Описание: This new edition provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice.Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions and, new for the second edition, also HIV dementia and multiple sclerosis. Final chapters cover important management issues including the use of palliative care strategies, biomarkers and  neuropsychology. Written by experts in the field internationally Neurodegenerative Disorders, Second Edition is a practical guide for clinicians that will be indispensable for the management of these conditions.

Pathogenesis of Neurodegenerative Disorders

Автор: Mark P. Mattson
Название: Pathogenesis of Neurodegenerative Disorders
ISBN: 1617372153 ISBN-13(EAN): 9781617372155
Издательство: Springer
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Цена: 191550.00 T
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Описание: As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer`s, Parkinson`s, and Huntington`s diseases.

Toxicity and Autophagy in Neurodegenerative Disorders

Автор: Jos? M. Fuentes
Название: Toxicity and Autophagy in Neurodegenerative Disorders
ISBN: 331913938X ISBN-13(EAN): 9783319139388
Издательство: Springer
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Цена: 139750.00 T
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Описание: Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.

Toxicity and Autophagy in Neurodegenerative Disorders

Автор: Jos? M. Fuentes
Название: Toxicity and Autophagy in Neurodegenerative Disorders
ISBN: 3319382128 ISBN-13(EAN): 9783319382128
Издательство: Springer
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Цена: 121890.00 T
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Описание: Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.


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