Nanobiotechnology in Neurodegenerative Diseases, Rai Mahendra, Yadav Alka
Автор: Kovacs Название: Neuropathology of Neurodegenerative Diseases Book and Online ISBN: 1107442427 ISBN-13(EAN): 9781107442429 Издательство: Cambridge Academ Рейтинг: Цена: 93990.00 T Наличие на складе: Поставка под заказ. Описание: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases. The book is packaged with a password, giving the user online access to all the text and images.
Название: Protein Misfolding in Neurodegenerative Diseases ISBN: 036738812X ISBN-13(EAN): 9780367388126 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact.
Protein Misfolding inNeurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS.
A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding
Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.
Автор: Dominguez Название: Neurodegenerative Diseases ISBN: 3642266037 ISBN-13(EAN): 9783642266034 Издательство: Springer Рейтинг: Цена: 176970.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume provides an overview of neurodegenerative diseases. Topics include the role histone deacetylases plays in neurodegenerative diseases, phosphodiesterase inhibition as a way to target synaptic dysfunction in Alzheimer`s disease, and more.
Автор: Rita Sattler; Christopher J. Donnelly Название: RNA Metabolism in Neurodegenerative Diseases ISBN: 3030078329 ISBN-13(EAN): 9783030078324 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--?mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--? coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--?directional transcription and production of repeat associated non--?ATG (RAN) translation products.This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.
Автор: Judit Ov?di; Ferenc Orosz Название: Protein folding and misfolding: neurodegenerative diseases ISBN: 9048181275 ISBN-13(EAN): 9789048181278 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson`s and Alzheimer`s diseases.
Автор: Theresa Natalie Название: Encyclopedia of Neurodegenerative Diseases: Volume III (Integrated Processes) ISBN: 1632411784 ISBN-13(EAN): 9781632411785 Издательство: Неизвестно Цена: 178950.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Integrated processes of neurodegenerative diseases have been provided in this all-inclusive book. It concentrates on biological mechanisms and neuoprotection of disease growth. It lays stress on the fundamental biological processes of neurodegeneration in
Автор: Essa M. Mohamed, Akbar Mohammed, Guillemin Gilles Название: The Benefits of Natural Products for Neurodegenerative Diseases ISBN: 3319803409 ISBN-13(EAN): 9783319803401 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.
Автор: Theresa Natalie Название: Encyclopedia of Neurodegenerative Diseases: Volume II (Therapeutic Intervention and Mechanisms) ISBN: 1632411776 ISBN-13(EAN): 9781632411778 Издательство: Неизвестно Цена: 156590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book examines generic mechanisms in neurodegenerative diseases. It throws light on the pathophysiological complexities of the mechanisms and factors that are most probably involved in a number of neurodegenerative and neuroinflammatory diseases inclu
1. What is this book series about? Foreword of Book Series Editor; O. Golubnitschaja
2. Preface; S. Mandel
3. Introductory chapter; S. Mandel and O. Golubnitschaja
Part II
4. Individual predispositions in healthy vasospastic individuals: Patient profiling for targeted prevention of "down-stream" pathologies as cost-effective personalised medicine; K. Yeghiazaryan, J. Flammer, O. Golubnitschaja
5. Idiopathic REM sleep behavior disorder as a long-term predictor of neurodegenerative disorders; S. Fulda and M. Manconi
6. New animal models of progressive neurodegeneration: tools for developing predictive diagnostics and identifying presymptomatic therapeutic targets; A. L. Marriott, D. A. Gill, C. A. Shaw, R. A. Tasker
7. Tau pathology: A selected view on the current status; I. Gozes
Part III
8. The Use of Biomarkers for Prediction and Prevention of Alzheimer's and Parkinson's Diseases; S. A. Mandel & A. D. Korczyn
9. Making clinical trials of Alzheimer's disease delay-of-onset a reality by use of a prognostic genetic biomarker; Iris Grossman
10. An update on CSF biomarkers of Parkinson's disease; Peter LeWitt, B Russell Huber, Jing Zhang
Part IV
11. Glaucomatous optic neuropathy: Risk assessment and potential targets for effective prevention and treatments tailored to the patient; O. Golubnitschaja, K. Yeghiazaryan, J. Flammer
Part V
12. Toward a personalized approach in amyotrophic lateral sclerosis: new developments in diagnosis, genetics, pathogenesis and therapies; B. Nefussy & V. E. Drory
13. Recent advances in ALS research: perspectives for personalized clinical application; C. Benkler, D. Offen, E. Melamed, T. Amit, S. Mandel, M. B.H. Youdim, O. Weinreb
Part VI
14. Exercise in Multiple Sclerosis - an Integral Component of Disease Management; A. Dцring, C. F. Pfueller, F. Pau, J. Dцrr
15. Bridging the Informatics Gap between Bench and Bedside: Implications to Neurodegenerative Diseases; A. Shabo (Shvo) & M. Scarpa
Part VII
16. Personalized Medicine In Rare Paediatric Neurometabolic Diseases; R. Tomanin, C. M. Bellettato, F. D'Avanzo, A. Zanetti, A. Ceci, D. Begley, M. Scarpa
Автор: Theresa Natalie Название: Encyclopedia of Neurodegenerative Diseases: Volume I (Disease Mechanisms) ISBN: 1632411768 ISBN-13(EAN): 9781632411761 Издательство: Неизвестно Цена: 156590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The mechanisms of neurodegenerative diseases are elucidated in this book. It throws light on the pathophysiological complexities of the mechanisms and factors that are most probably involved in a number of neurodegenerative and neuroinflammatory diseases
Автор: Abel Lajtha; Naren L. Banik Название: Role of Proteases in the Pathophysiology of Neurodegenerative Diseases ISBN: 1441933603 ISBN-13(EAN): 9781441933607 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret.
Автор: Mahendra Rai; Alka Yadav Название: Nanobiotechnology in Neurodegenerative Diseases ISBN: 3030309290 ISBN-13(EAN): 9783030309299 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including nanotechnologists, biotechnologists, pharmacists, medical professionals, bioengineers, biochemists and researchers working in this field. Nanobiotechnology in Neurodegenerative Diseases include various chapters including neurodegeneration and neurodegenerative diseases, nanotechnology for the rescue of neurodegenerative diseases, promising potential of nanomaterials for diagnosis and therapy of neurodegenerative diseases, nanotechnology mediated nose-to-brain drug delivery, and formulation and characterization of intranasal nanoparticles of antiretroviral drugs.
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