Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 16 presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field.
This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment.
Автор: Anscher Название: Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment ISBN: 3319455923 ISBN-13(EAN): 9783319455921 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.
Автор: Bonavida, Benjamin Название: Improving The Therapeutic Ratio In Head And Neck Cancer,6 ISBN: 012817868X ISBN-13(EAN): 9780128178683 Издательство: Elsevier Science Рейтинг: Цена: 151590.00 T Наличие на складе: Поставка под заказ. Описание: Hydropedology is a microcosm for what is happening in Soil Science. This title brings together pedology (soil characteristics) with hydrology (movement of water) to understand and achieve the goals associated with modern soil science. It includes case studies that demonstrate the need for hydropedology in various practical applications.
Автор: Philip J. Tofilon; Kevin Camphausen Название: Increasing the Therapeutic Ratio of Radiotherapy ISBN: 3319408526 ISBN-13(EAN): 9783319408521 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy.
In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations.
Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection).
Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.
Автор: Tofilon Philip J., Camphausen Kevin Название: Increasing the Therapeutic Ratio of Radiotherapy ISBN: 3319822012 ISBN-13(EAN): 9783319822013 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues.
Название: Introduction to Body Composition Assessment Using the Deuterium Dilution Technique with Analysis of Urine Samples by Isotope Ratio Mass Spectrometry ISBN: 9203139133 ISBN-13(EAN): 9789203139137 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 33270.00 T Наличие на складе: Невозможна поставка. Описание: This publication complements the IAEA publication Assessment of Body Composition and Total Energy Expenditure in Humans Using Stable Isotope Techniques by providing practical guidance on the use of stable isotope techniques to assess body composition in settings where biological samples can be analysed by isotope ratio mass spectrometry.
Название: Introduction to Body Composition Assessment Using the Deuterium Dilution Technique with Analysis of Urine Samples by Isotope Ratio Mass Spectrometry ISBN: 9202141134 ISBN-13(EAN): 9789202141131 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 33270.00 T Наличие на складе: Невозможна поставка. Описание: This publication complements the IAEA publication Assessment of Body Composition and Total Energy Expenditure in Humans Using Stable Isotope Techniques by providing practical guidance on the use of stable isotope techniques to assess body composition in settings where biological samples can be analysed by isotope ratio mass spectrometry.
Автор: Xia, Ping Godley, Andrew Shah, Chirag Suh, John Название: Strategies for radiation therapy treatment planning ISBN: 0826122442 ISBN-13(EAN): 9780826122445 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 66880.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Provides a step-by-step guide to implementing external beam treatment plans that meet clinical requirements for each major disease site. The book focuses on the technical aspects of treatment planning and the major challenges in creating highly conformal dose distributions, referenced to as treatment plans, for external beam radiotherapy.
Автор: Christian Herfarth; Peter Schlag; Peter Hohenberge Название: Therapeutic Strategies in Primary and Metastatic Liver Cancer ISBN: 3642826377 ISBN-13(EAN): 9783642826375 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Therapeutic concepts comprise sys- temic therapy and organ-related therapeutic methods, in- cluding surgical resection, changes in the blood supply, re- gional selective chemotherapy, and other localized or regional, highly specialized forms of therapy.
Автор: Stark Malcolm Название: Pancreatic Cancer: Evaluation and Therapeutic Strategies ISBN: 1632427397 ISBN-13(EAN): 9781632427397 Издательство: Неизвестно Рейтинг: Цена: 155570.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eleven summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells.
From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer.
Автор: Samantha Haggerty Название: Bladder Cancer: Risk Factors, Emerging Treatment Strategies and Challenges ISBN: 1633216667 ISBN-13(EAN): 9781633216662 Издательство: Nova Science Рейтинг: Цена: 215410.00 T Наличие на складе: Невозможна поставка. Описание: An Introduction Third Edition 2015. This book describes the principles of the blast furnace process and especially the control of the process. As a starting point, the blast furnace is seen as a simple iron ore smelter, while gradually the physical, chemical and metallurgical background of the blast furnace process is clarified. The book focuses on the control of the blast furnace process with respect to thermal control, gas flow control and casthouse operation. In this book, all essential process details are described and a special focus is on optimization of coal injection. The optimization of the blast furnace process is not only
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