The Chemical Biology of Long Noncoding Rnas, Jurga Stefan, Barciszewski Jan

Автор: Riki Kurokawa
Название: Long Noncoding RNAs
ISBN: 4431555757 ISBN-13(EAN): 9784431555759
Издательство: Springer
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Цена: 130430.00 T
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Описание: This book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests.

Автор: Shinichi Nakagawa; Tetsuro Hirose
Название: Nuclear Bodies and Noncoding RNAs
ISBN: 1493922521 ISBN-13(EAN): 9781493922529
Издательство: Springer
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Цена: 88500.00 T
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Описание: This volume focuses on cytological, biochemical, and molecular biological methods to identify and examine the function of each nuclear body, with an emphasis on the analysis of long non-coding RNAs.

Автор: Ahmad M. Khalil; Jeff Coller
Название: Molecular Biology of Long Non-coding RNAs
ISBN: 1493945289 ISBN-13(EAN): 9781493945283
Издательство: Springer
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Цена: 130590.00 T
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Описание: This book examines key issues in lncRNA biology, including critical studies that have led to the discovery and annotation of lncRNAs in numerous species and the molecular mechanisms for a few lncRNA that have begun to emerge.

Автор: Khalil Ahmad M.
Название: Molecular Biology of Long Non-Coding Rnas
ISBN: 3030170888 ISBN-13(EAN): 9783030170882
Издательство: Springer
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Цена: 102480.00 T
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Описание: This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

Автор: Ahmad M. Khalil
Название: Molecular Biology of Long Non-coding RNAs
ISBN: 3030170853 ISBN-13(EAN): 9783030170851
Издательство: Springer
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Цена: 102480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

Автор: ?ur?ica Ugarkovi?
Название: Long Non-Coding RNAs
ISBN: 364226655X ISBN-13(EAN): 9783642266553
Издательство: Springer
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Цена: 156720.00 T
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Описание: Long Non-Coding RNAs provides an overview of the rapidly advancing field, and describes the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems. Readers will find a discussion of the role of ncRNAs in sex chromosome dosage compensation, and more.

Название: Long non-coding rnas in human disease
ISBN: 3319239066 ISBN-13(EAN): 9783319239064
Издательство: Springer
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Цена: 130610.00 T
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Описание: The role oflncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, pastretroelements integrated within the human genome, as well as the role thesepseudogene-derived lncRNAs play in cancer development are discussed in detail.

Автор: Yi Feng; Lin Zhang
Название: Long Non-Coding RNAs
ISBN: 1493980351 ISBN-13(EAN): 9781493980352
Издательство: Springer
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Цена: 102480.00 T
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Описание: This volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA.

Автор: Yi Feng; Lin Zhang
Название: Long Non-Coding RNAs
ISBN: 1493933760 ISBN-13(EAN): 9781493933761
Издательство: Springer
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Цена: 130430.00 T
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Описание: This volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA.

Автор: Morris Kevin V.
Название: Long Non-Coding Rnas in Human Disease
ISBN: 3319795511 ISBN-13(EAN): 9783319795515
Издательство: Springer
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Цена: 93160.00 T
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Описание: This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Автор: Nils Walter; Sarah A. Woodson; Robert T. Batey
Название: Non-Protein Coding RNAs
ISBN: 3540708332 ISBN-13(EAN): 9783540708339
Издательство: Springer
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Цена: 231990.00 T
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Описание: The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, highlighting just one example of a large number of non-protein coding RNAs. This work features chapters in the field of Biophysics of RNA that provide a view of the status of this field.

Автор: Xia Li; Juan Xu; Yun Xiao; Shangwei Ning; Yunpeng
Название: Non-coding RNAs in Complex Diseases
ISBN: 9811344868 ISBN-13(EAN): 9789811344862
Издательство: Springer
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Цена: 121110.00 T
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Описание: This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.