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Myelodysplastic Syndrome: From Diagnosis to Treatment, Emma E. Steffensen


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Автор: Emma E. Steffensen
Название:  Myelodysplastic Syndrome: From Diagnosis to Treatment
ISBN: 9781536179972
Издательство: Nova Science
Классификация:
ISBN-10: 1536179973
Обложка/Формат: Hardback
Страницы: 377
Вес: 0.64 кг.
Дата издания: 22.07.2020
Язык: English
Размер: 155 x 232 x 23
Читательская аудитория: Professional & vocational
Ключевые слова: Haematology
Подзаголовок: From diagnosis to treatment
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Поставляется из: Англии
Описание: In this compilation, the authors review the biological aspects of myelodysplastic syndrome disease, diagnosis, and treatment, as well as innovations involving genetics and new treatment perspectives. Myelodysplastic syndromes are a heterogeneous group of clonal haematopoietic stem cells disorders characterized by dysplasia, as well as peripheral blood cytopenias with a hypercellular marrow and ineffective hematopoiesis. Myelodysplastic syndromes are frequently associated with acute and chronic inflammation, and autoimmune disorders such as: rheumatoid arthritis, bowel disease, diverse types of vasculitis, autoimmune anemias, several rheumatic and skin disorders, and certain thyroid disorders. Spliceosome mutations are the most frequent mutations found in blood and bone marrow cells of myelodysplastic syndromes patients. As such, the authors explore the four predominant splicing factor genes: SF3B1, SFRS2, U2AF1, ZRSR2. Subsequently, this collection discusses the CSNK1A1 gene in the context of myelodysplastic syndromes. It is located at 5q32 within the deleted region, which encodes for casein kinase 1I± (CK1I±). CK1I± is a component of a multiprotein I?-catenin destruction complex that regulates Wnt/I?-catenin and p53 pathways. The concluding study focuses on the mutations in epigenetic modifiers occur which myelodysplastic syndromes and drive this disease, such as: DNA methylation, histone acetylation, and RNA interference that alters gene expression.

Diagnosis and Management of Myelodysplastic Syndromes: A Clinical Guide

Автор: Nazha Aziz
Название: Diagnosis and Management of Myelodysplastic Syndromes: A Clinical Guide
ISBN: 3030518779 ISBN-13(EAN): 9783030518776
Издательство: Springer
Цена: 130430.00 T
Наличие на складе: Невозможна поставка.
Описание: Theologies on the Move examines how the experiences of migration and pilgrimage that are created as a result of the pressures of neoliberal capitalism shape theological and religious traditions. Based on these insights, the contributors examine what difference religion can make in a world dominated by the interests of the few rather than the many.

Myelodysplastic Syndromes, An Issue Of Hematology/Oncology Clinics Ofnorth America,24-2

Автор: Ebert, Benjamin
Название: Myelodysplastic Syndromes, An Issue Of Hematology/Oncology Clinics Ofnorth America,24-2
ISBN: 1437722032 ISBN-13(EAN): 9781437722031
Издательство: Elsevier Science
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Цена: 80560.00 T
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Описание: Major strides have been made in the treatment and understanding of Myelodysplasia. This title includes articles that illustrate the rapid progress in MDS research, from molecular pathophysiology to improved therapies.

Myelodysplastic Syndromes An Issue Of Hematology/Oncology Clinics Of North America,34-2

Автор: Steensma, David
Название: Myelodysplastic Syndromes An Issue Of Hematology/Oncology Clinics Of North America,34-2
ISBN: 0323722598 ISBN-13(EAN): 9780323722599
Издательство: Elsevier Science
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Цена: 90380.00 T
Наличие на складе: Поставка под заказ.
Описание: Ce Guide de Poche se base sur TOGAF(R) Version 9.2 Entreprise Edition et il fait autorite en la matiere car il en reprend des elements de documentation.En introduisant de maniere concise TOGAF(R), sa lecture ne necessite pas d`avoir des connaissances prealables sur l`architecture d`entreprise.Ce livre vous est principalement destine si vous etes un professionnel concerne par l`architecture: architecte d`entreprise, architecte metiers, architecte des systemes d`information, architecte des donnees, architecte systemes, architecte solutions ou dirigeant cherchant une premiere introduction a TOGAF(R).Ce guide de Poche fournit les elements suivants:¢ une presentation generale de TOGAF(R);¢ une introduction a la Methode de Developpement d`Architecture;¢ une introduction aux notions de Cadre de Contenu d`Architecture et de Continuum d`Entreprise;¢ une introduction au Cadre de Capacite d`Architecture, permettant de creer et de mettre en oeuvre une fonction d`architecture au sein d`une entreprise.Avec plus de 30.000 praticiens certifies dans le monde, TOGAF(R) est le cadre d`Architecture d`Entreprise le plus repandu dans les entreprises. Il s`appuie sur une approche iterative de transformation de l`entreprise qui couvre:¢ le cycle de vie complet des architectures produites, de la vision a la maintenance, en s`attachant a livrer aux acteurs concernes la valeur metier et les qualites attendues;¢ et le developpement continu de la capacite a faire de l`Architecture d`Entreprise.TOGAF(R) a pour objectifs d`ameliorer l`agilite et la performance de l`entreprise, de permettre l`innovation et l`emergence de nouveaux business models, de maitriser la transformation de l`entreprise.TOGAF(R) est un standard de The Open Group et il a beneficie de la mise en commun et de la coordination des bonnes pratiques de plusieurs centaines d`entreprises des domaines IT et industriels.

Myelodysplastic Syndromes

Автор: Franz Schmalzl; G.J. Mufti
Название: Myelodysplastic Syndromes
ISBN: 3540529667 ISBN-13(EAN): 9783540529668
Издательство: Springer
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Цена: 102480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The myelodysplastic syndromes pose important clinical and scientific challenges which in recent years have attracted growing interest within the fields of haemato-oncology and molecular genetics. This study explores the potential of these syndromes as a model for the study of leukaemogenesis.

The Myelodysplastic Syndromes

Автор: Judit V?rkonyi
Название: The Myelodysplastic Syndromes
ISBN: 940178390X ISBN-13(EAN): 9789401783903
Издательство: Springer
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Цена: 191550.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Myelodysplastic syndromes (MDS) are the most common hematological malignancies involving mostly the elderly population. This volume provides and updated overview of important clinical aspects of the disease.

Clinician`s Manual on Myelodysplastic Syndromes

Автор: List
Название: Clinician`s Manual on Myelodysplastic Syndromes
ISBN: 1858734274 ISBN-13(EAN): 9781858734279
Издательство: Springer
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Цена: 49370.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: to myelodysplastic syndromes.- Etiology and pathophysiology.- Signs and symptoms of myelodysplastic syndromes.- Clinical assessment and diagnosis.- Classification of myelodysplastic syndromes.- Management of myelodysplastic syndromes.

The Myelodysplastic Syndromes

Автор: V?rkonyi
Название: The Myelodysplastic Syndromes
ISBN: 9400704399 ISBN-13(EAN): 9789400704398
Издательство: Springer
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Цена: 191560.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Myelodysplastic syndromes (MDS) are the most common hematological malignancies involving mostly the elderly population. The major morbidity relates to patients’ symptomatic cytopenias.MDS was previously named as  “preleukemia “ or “ smoldering leukemia” as the lack of terminal cells in MDS and because about 25% of all cases progresses into acute myeloid leukemia.According to various reports the annual incidence of MDS ranges widely from 2-12 per 100.000, increasing to 30-50 cases per 100.000 among persons aged  70  or older. It is believed that the true incidence of MDS have been underestimated however it seems to be comparable to that for multiple myeloma and chronic lymphocytic leukemia.  In the past decade much progress had been made; we know more on the disease pathology, there is more emphasis on the care and more targeted therapy had been invested. Athors provide updated knowledge in this book on all clinically important aspects of the disease. Hot topics of our days are discussed in chapters by outstanding and well known scientists from all over the world. We would offer this product both for medical students and postgraduates as well as for all who are interested in this very exciting and fast progressing field of hematology.With this work authors should call attention on the disease for decision makers in healt care systems as well. 


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