Dancing Protein Clouds: Intrinsically Disordered Proteins In Health And Disease, Part A,166, Uversky, Vladimir N.
Автор: Salvi, Nicola Название: Intrinsically Disordered Proteins ISBN: 0128163488 ISBN-13(EAN): 9780128163481 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Невозможна поставка. Описание:
Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs.
Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs.
Provides in-depth discussion of fundamental IDP and IDR dynamics, function, and binding, with mechanistic insight to support new drug development
Describes the role of new computational and experimental approaches in characterizing the binding of IDPs to their functional targets
Features chapter contributions from international experts in IDP and IDR biochemical function and methods of study
Автор: Isabella C. Felli; Roberta Pierattelli Название: Intrinsically Disordered Proteins Studied by NMR Spectroscopy ISBN: 3319371177 ISBN-13(EAN): 9783319371177 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Nuclear Magnetic Resonance and Bioinformatics Studies on Intrinsically Disordered Proteins.- Structure and Dynamics of Intrinsically Disordered Proteins.- NMR methods for the study of IDP structure, dynamics and interactions: general overview and practical guidelines.- Ensemble Calculation for IDPs Using NMR Parameters.- NMR Spectroscopic Studies of the Conformational Ensembles of Intrinsically Disordered Proteins.- Recombinant IDPs for NMR: Tips and Tricks.- Biophysical Methods to Investigate Intrinsically Disordered Proteins: Avoiding an "Elephant and Blind Men" Situation.- Application of SAXS for the Structural Characterization of IDPs.- Bioinformatics Approaches for Predicting Disordered Protein Motifs.- Towards Understanding Protein Disorder In-Cell.- The Protein Ensemble Database.- Order and Disorder in the Replicative Complex of Paramyxoviruses.- Druggability of Intrinsically Disordered Proteins.- Beta Amyloid Hallmarks: From Intrinsically Disordered Proteins to Alzheimer's Disease.
Автор: Vladimir N. Uversky Название: Intrinsically Disordered Proteins ISBN: 331908920X ISBN-13(EAN): 9783319089201 Издательство: Springer Рейтинг: Цена: 60940.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs).
Автор: Isabella C. Felli; Roberta Pierattelli Название: Intrinsically Disordered Proteins Studied by NMR Spectroscopy ISBN: 3319201638 ISBN-13(EAN): 9783319201634 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrinsic protein disorder is now recognized as one of the key features for a large variety of cellular functions, where structural flexibility presents a functional advantage in terms of binding plasticity and promiscuity and this volume explores this exciting new research. Recent progress in the field has radically changed our perspective to study IDPs through NMR: increasingly complex IDPs can now be characterized, a wide range of observables can be determined reporting on the structural and dynamic properties, computational methods to describe the structure and dynamics are in continuous development and IDPs can be studied in environments as complex as whole cells. This volume communicates the new exciting possibilities offered by NMR and presents open questions to foster further developments. Intrinsically Disordered Proteins Studied by NMR Spectroscopy provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
Автор: Vladimir N. Uversky; A. Keith Dunker Название: Intrinsically Disordered Protein Analysis ISBN: 1493962302 ISBN-13(EAN): 9781493962303 Издательство: Springer Рейтинг: Цена: 153720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis :Methods and Experimental Tools, expert researchers explore the high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 1 includes sections on assessing IDPs in the living cell,NMR based techniques, vibrational spectroscopy, and other spectroscopic techniques. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Intrinsically Disordered Protein Analysis: Methods and Experimental Tools helps scientists further their investigations of these fascinating and dynamic molecules.
Автор: Vladimir N. Uversky; A. Keith Dunker Название: Intrinsically Disordered Protein Analysis ISBN: 1493944843 ISBN-13(EAN): 9781493944842 Издательство: Springer Рейтинг: Цена: 135090.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The second volume in the series on the experimental methods used to identify IDPs and analyze their structure, this publication includes reproducible protocols for single molecule techniques and methods to assess protein size and shape, among many others.
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