Neuroprotection In Autism, Schizophrenia And Alzheimer`S Disease, Gozes, Illana

Автор: Gozes, Illana
Название: Neuroprotection in Alzheimer`s Disease
ISBN: 0128036907 ISBN-13(EAN): 9780128036907
Издательство: Elsevier Science
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Цена: 117900.00 T
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Описание: Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. . This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics.

Автор: Gidday Jeffrey M., Perez-Pinzon Miguel A., Zhang John H.
Название: Innate Tolerance in the CNS: Translational Neuroprotection by Pre- And Post-Conditioning
ISBN: 1493941771 ISBN-13(EAN): 9781493941773
Издательство: Springer
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Цена: 186330.00 T
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Описание: Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.

Автор: Uchida
Название: Neuroprotection and Regeneration of the Spinal Cord
ISBN: 4431545018 ISBN-13(EAN): 9784431545019
Издательство: Springer
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Цена: 149060.00 T
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Описание: Neuroprotection and Regeneration of the Spinal Cord comprehensively covers the most recent research in the field of spinal cord injury.

Автор: Sharma, Hari Shanker
Название: Neuropharmacology Of Neuroprotection,254
ISBN: 0128208139 ISBN-13(EAN): 9780128208137
Издательство: Elsevier Science
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Цена: 224520.00 T
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Описание: Neuropharmacology of Neuroprotection Volume 254, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Автор: Alexzander A.A. Asea; Ian R. Brown
Название: Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection
ISBN: 9048178134 ISBN-13(EAN): 9789048178131
Издательство: Springer
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Цена: 213360.00 T
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Описание: This book reviews current progress on heat shock proteins in the brain and their implications for neurodegenerative diseases, neuroprotection, aging and control of life span. It features contributions from laboratories from major universities around the world.

Автор: Manangos; Lal
Название: Emerging Strategies in Neuroprotection
ISBN: 1468467980 ISBN-13(EAN): 9781468467987
Издательство: Springer
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Цена: 46570.00 T
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Описание: In the 1980s the revolutions of molecular biology have been applied aggressively to the neurosciences with molecular cloning for neuropeptide precursors, many important neurochemical en- zymes, and receptors for numerous transmitters.

Автор: Nakazawa
Название: Neuroprotection and Neuroregeneration for Retinal Diseases
ISBN: 4431549641 ISBN-13(EAN): 9784431549642
Издательство: Springer
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Цена: 149060.00 T
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Описание: This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa.

Автор: Akaike Akinori, Shimohama Shun, Misu Yoshimi
Название: Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
ISBN: 9811341664 ISBN-13(EAN): 9789811341663
Издательство: Springer
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Цена: 46570.00 T
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Описание: This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases.

Автор: Kewal K. Jain
Название: The Handbook of Neuroprotection
ISBN: 1493994670 ISBN-13(EAN): 9781493994670
Издательство: Springer
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Цена: 167700.00 T
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Описание: This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.

Автор: Reich David L., Mayer Stephan A., Uysal Suzan
Название: Neuroprotection in Critical Care and Perioperative Medicine
ISBN: 0190280255 ISBN-13(EAN): 9780190280253
Издательство: Oxford Academ
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Цена: 91870.00 T
Наличие на складе: Невозможна поставка.
Описание: Neuroprotection is becoming an increasingly recognized and important part of critical care and perioperative medicine. As human beings survive increasingly severe life-threatening injuries and complex surgical interventions, it has become clear that neurologic injury and dysfunction is a
primary driver of long-term outcome and disability. Neuroprotection is currently under-recognized as the primary objective in promoting recovery from life-threatening injuries, illnesses, and procedures.

To address this knowledge gap, Neuroprotection in Critical Care and Perioperative Medicine provides a concise review of the current state of the art of clinical care and research. Within the context of critical care, the specific topics covered will include the primary forms of brain injury on which
neuroprotection research and intervention has traditionally focused, such as traumatic brain injury, cardiac arrest, acute ischemic stroke, and intracranial hemorrhage, as well as CNS injuries related to sepsis and acute respiratory distress syndrome, mechanical circulatory support, and premature
birth. Within the context of perioperative care, the specific topics covered will include anesthetic and perioperative strategies to reduce brain injury from cardiac surgery, aortic surgery and endovascular repair, carotid endarterectomy, vascular and endovascular neurosurgery, and other major
surgical procedures.

Автор: Cesario V. Borlongan; Ole Isacson; Paul R. Sanberg
Название: Immunosuppressant Analogs in Neuroprotection
ISBN: 1468497421 ISBN-13(EAN): 9781468497427
Издательство: Springer
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Цена: 102480.00 T
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Описание: An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant "drugs" to neuroprotective "agents". The book focuses on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. It also discusses their efficacy and mechanisms of action in vitro and in vivo models of CNS disease, and provides laboratory studies with compelling clinical indications for Alzheimer's disease, Huntington's disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction.

Автор: Jain
Название: The Handbook of Neuroprotection
ISBN: 1493994646 ISBN-13(EAN): 9781493994649
Издательство: Springer
Рейтинг:
Цена: 167700.00 T
Наличие на складе: Поставка под заказ.
Описание: This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.