Autophagy In Health And Disease,175, Galluzzi, Lorenzo
Автор: Hayat, M. A. Название: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Inf ISBN: 0128054204 ISBN-13(EAN): 9780128054208 Издательство: Elsevier Science Рейтинг: Цена: 156080.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy.
Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections.
Presents the most advanced information regarding the role of the autophagic system in life and death
Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both
Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment
Includes chapters authored by leaders in the field around the globe--the broadest, most expert coverage available
The food we eat affects our lives much more than we think. Extra weight is just the beginning; toxins that are poisoning our bodies affect every area of our lives. Low productivity, confusion, brain fog, and feeling down are common signs of a bad diet. If you wake up tired after 8 hours of sleep, feeling sluggish and desperate to go back to sleep - your body needs help.
Unfortunately, the food of today is focused more on the caloric value than nutritional value. Pesticides are used on fruits, chemical fertilizers are used on vegetables, and animals are fed concentrated food before being slaughtered. All of these factors influence the quality of our food and may lead to several diseases, especially related to high blood sugar levels.
Can we reverse all of these and put a stop to it?
Is medication a solution?
Medication is not designed to cure, but instead, it was intended to make the disease a bit more pleasant by masking the symptoms.
Finding organic food in urban areas is quite a difficult task, but even if you can't do it, there is a way. Autophagy is the process of recycling damaged parts of proteins and organelles at a cellular level. It has plenty of benefits for the human body, especially in terms of health.
Rediscover centuries-old secrets to a healthy and long life. Activate the anti-aging process, lose weight, and increase energy using your body's natural intelligence. Autophagy will clean your body of toxins and bring it to its full potential.
Discover the amazing secrets behind the power of fasting and heal your body from within
From reading this book, you will learn:
What is autophagy and why it is important for your health and longevity
How you can naturally protect and heal your body from diseases
How to maximize its effects and benefits
Important information about Intermittent Fasting, Ketosis, HIIT, and Protein Fast
Types of food and supplements that can induce autophagy
Ways to achieve autophagy without doing prolonged fasting
Why fasting is so much more than just a way to lose weight
How to make fasting a way of life
And much, much more...
It is not holistic or "voodoo" medicine, Japanese cell biologist Yoshinori Ohsumi won the Nobel Prize in Medicine in 2016 for his research on autophagy, so you should take it very seriously.
This book has strategies and practical solutions. After reading it, you will know what to do, how to do it, and why it works You don't need to invest hundreds of dollars into hard-to-find ingredients to make it work; you can start applying knowledge as you read the book
So even if you're tired and unhealthy, you can get mental clarity, balance, and health.
Take a second to imagine how you'll feel once you're full of health and strength, how it is to wake up in the morning fresh and full of energy, even before you had your coffee
And if you have a burning desire to reclaim your health, and live a life full of energy, then scroll up and click "Add to Cart." Do you want better value for your money? With purchase of Paperback you will receive a Free Kindle Version
Many modern recommendations for improved health and wellness leave us feeling like we're expected to dance upon a tightrope just to avoid illness and chronic discomfort. We hear that eggs are good for us; then we hear that they're bad for us; next, we learn that we should only be eating the egg whites; then, only the yolks; and finally, that we should eat the entire egg, but only at certain times of day, or with specific nutrient pairings.
We're supposed to exercise more, but also rest more--meanwhile, we have to avoid going overboard with either activity. We should be eating less, but never skipping meals. We need more vitamin D, and should be practicing grounding and enjoying exercise outdoors... but we have to stay out of the sun.
If you're feeling frustrated, overwhelmed, dejected, exhausted, and just about ready to chuck every piece of fitness advice you've ever received out the window, then this is the book for you.
Autophagy is a hot topic within the health and wellness community, despite being a relatively new discovery; what sets it apart from other diets and lifestyle trends is that it isn't a fad, or a plan designed to sell cookbooks, pre-packaged meals, or lifestyle products--it's pure science. While some of the jargon used to describe it might be intimidating, the concepts of autophagy are less confusing than many dietary trends because they are consistent and reflective of the realities in our everyday experiences.
Furthermore, autophagy isn't only recommended as a weight loss tool, or a cure for illness; its potential benefits are vast and varied, from improved metabolic function, to reduced risk of dementia, to enhanced physical performance, and even reversed signs of aging. There may be no such thing as a panacea in this world, but autophagy sure does come close to meeting its definition.
Autophagy is a process of cellular cleansing. It's the natural process by which our cells recycle old, broken, or infected molecular matter. We all have autophagic responses at work in our bodies already, but the realities of modern life often work to slow or inhibit the process of autophagy as we grow older. If we can master the art of triggering enhanced autophagy, though, the potential rewards we can reap are truly staggering.
Within these pages, you will discover:
What autophagy is, and how it works on a cellular level
How to comprehend, and even describe, autophagic processes without any previous knowledge of cellular biology or metabolic function
The evolutionary purpose of autophagy
How to trigger autophagy through diet, physical activity, and manufactured stress
How to activate autophagy through fasting, and what to expect during a fast of almost any length
How autophagy works to promote weight loss, and then maintain reduced weight in the long-term
How to use autophagic processes to delay or prevent signs of aging
How autophagy can work to cure illness, chronic pain, and disease
How autophagy may hold the key to an eventual cure for cancer
Автор: Kursad Turksen Название: Autophagy in Health and Disease ISBN: 3030074579 ISBN-13(EAN): 9783030074579 Издательство: Springer Рейтинг: Цена: 107130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases.
The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.
Автор: Kursad Turksen Название: Autophagy in Health and Disease ISBN: 3319981455 ISBN-13(EAN): 9783319981451 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases.
The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.
Автор: Nikolai Gorbunov Название: Autophagy: Principles, Regulation & Roles in Disease ISBN: 1619422662 ISBN-13(EAN): 9781619422667 Издательство: Nova Science Рейтинг: Цена: 271380.00 T Наличие на складе: Невозможна поставка. Описание: Gives an overview of the biomedical aspects of autophagy research, a large interdisciplinary field emerging on intersection of: cell, developmental, and cancer biology; tissue remodelling and plasticity, ageing and longevity; immunology, microbiology, toxicology, and pathobiology; regenerative and adaptive biomedicine; and, pharmacology.
Автор: Jos? M. Fuentes Название: Toxicity and Autophagy in Neurodegenerative Disorders ISBN: 3319382128 ISBN-13(EAN): 9783319382128 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.
Автор: Maiuri Название: Autophagy Networks in Inflammation ISBN: 3319300776 ISBN-13(EAN): 9783319300771 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.
Автор: Iman Tavassoly Название: Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells ISBN: 331914961X ISBN-13(EAN): 9783319149615 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.
