Advances From Computational And Experimental Studies Of Chromatin Structure And Epigenetics Mechanisms,122, Christov, Christo
Автор: Tollefsbol Trygve Название: Epigenetics in Human Disease ISBN: 0128122153 ISBN-13(EAN): 9780128122150 Издательство: Elsevier Science Рейтинг: Цена: 153830.00 T Наличие на складе: Поставка под заказ. Описание: Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders.
Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies.
Автор: Trygve Tollefsbol Название: Medical Epigenetics ISBN: 0128032391 ISBN-13(EAN): 9780128032398 Издательство: Elsevier Science Рейтинг: Цена: 151310.00 T Наличие на складе: Поставка под заказ. Описание: "
Medical Epigenetics" is an inclusive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic disease that affect these systems, and modes of treating epigenetic-based disorders and diseases. This book provides stand-alone coverage of all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. It is useful not only to physicians, nurses, medical students, and many others directly involved with healthcare, but also investigators in life sciences, biotech companies, graduate students, and all others who are interested in more applied aspects of epigenetics.
The expansion of the field of epigenetics has brought a wealth of information with respect to variations in phenotypes that are heritable. In addition, many advances have emerged that have shown epigenetic aberrations as central to a number of diseases and disorders that were previously thought to be manifested primarily through genetic factors. Along with the remarkable studies that have been made in our understanding of epigenetic-based diseases and disorders has come new information that allows treatments that target these many epigenetic aberrations. "Medical Epigenetics" brings all of this knowledge together to comprehensively review the state of medical epigenetics in one defining volume.
The basic design of "Medical Epigenetics" is to lead the reader from the fundamental mechanisms of epigenetics as they apply to humans through approaches for treating epigenetic-based diseases. This book begins with the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics. "Medical Epigenetics" closes with a chapter on future prospects in medical epigenetics. This book is by far the most complete book in the area of applied epigenetics. Focuses on practical and applied aspects of medical epigeneticsIncludes peer-reviewed chapters with up-to-date coverage of emerging topics in medical epigenetics by leading expertsAppeals to those interested in fundamental epigenetics and inheritance, as well as those with more clinical interests including practicing physicians and other health care professionalsCovers the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics
Автор: Patel Название: Handbook of Nutrition, Diet, and Epigenetics ISBN: 3319555294 ISBN-13(EAN): 9783319555294 Издательство: Springer Рейтинг: Цена: 492870.00 T Наличие на складе: Поставка под заказ. Описание: This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.
This title includes a number of Open Access chapters.
This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including:
host-pathogen interactions
causal relationships between genes and the environment
the effects of environmental chemicals on gene expression
DNA methylation
The book also covers the analysis and provides models for understanding the epigenetics-pathology connection.
This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.
Автор: Fink, George Название: Stress Genetics, Epigenetics And Genomics ISBN: 012813156X ISBN-13(EAN): 9780128131565 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Поставка под заказ. Описание:
The effect of stress on our emotional and physical health can be devastating. There have been significant advances in our understanding of stress genetics and genomics, and the field of epigenetics has flourished during this time, yet many remain unfamiliar with the latest concepts on these topics. This intense public, research, and clinical interest in stress is reflected in our edited Handbook of Stress series, each volume addressing a specific area within the field of stress edited by experts in each subfield. Stress Genetics, Epigenetics, and Genomics, Volume 4 in the series, covers the influence genetics, epigenetics, and genomics have on physiologic stress and provides a quick orientation to the subject for research, clinic, and everyday life. Integrated closely with new behavioral findings and relevance to human conditions, the concepts and data in this volume offer readers cutting-edge information on the genetics of stress. This volume is of prime interest to neuroscientists, clinicians, researchers, academics, and students in Neuroendocrinology, Neuroscience, Biomedicine, Endocrinology, Psychology, Psychiatry and some aspects of the Social Sciences including stress and its management in the workplace from a preventative, diagnostic, and therapeutic perspective.
Автор: Paolo Sassone Corsi; Yves Christen Название: Epigenetics, Brain and Behavior ISBN: 3642441084 ISBN-13(EAN): 9783642441080 Издательство: Springer Рейтинг: Цена: 148010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.
Автор: Jan Baedke Название: Above the Gene, Beyond Biology: Toward a Philosophy of Epigenetics ISBN: 0822945215 ISBN-13(EAN): 9780822945215 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 49890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Jan Baedke offers the first comprehensive philosophical discussion of epigenetic concepts, explanations, and methodologies so that we can better understand this "epigenetic turn" in the life sciences from a philosophical perspective.
Автор: Reinhard Heil; Stefanie B. Seitz; Harald K?nig; J? Название: Epigenetics ISBN: 3658144599 ISBN-13(EAN): 9783658144593 Издательство: Springer Рейтинг: Цена: 55890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Modern epigenetics unites scientists from life sciences, organic chemistry as well as computer and engineering sciences to find an answer to the question of how environmental influences can have a lasting effect on gene expression, maybe even into the next generations.
Автор: Fazlul H. Sarkar Название: Epigenetics and Cancer ISBN: 9401780803 ISBN-13(EAN): 9789401780803 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book examines the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. It covers epigenetic regulation of mRNA as well as epigenetic regulation of miRNA in multiple cancers.
Автор: Tollefsbol, Trygve Название: Handbook of Epigenetics ISBN: 0128053887 ISBN-13(EAN): 9780128053881 Издательство: Elsevier Science Рейтинг: Цена: 176290.00 T Наличие на складе: Поставка под заказ. Описание: Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. . The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders.
Автор: Trygve Tollefsbol Название: Personalized Epigenetics ISBN: 0124201350 ISBN-13(EAN): 9780124201354 Издательство: Elsevier Science Рейтинг: Цена: 93200.00 T Наличие на складе: Невозможна поставка. Описание:
Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.
The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.
Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
Автор: Igor Kovalchuk; Franz J. Zemp Название: Plant Epigenetics ISBN: 1493957562 ISBN-13(EAN): 9781493957569 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The discovery of DNA as the genetic material brought great hope to scientists all over the world. It was believed that many of the lingering questions in genetics and the mechanisms of heredity would fnally be answered. However, as often is the case in science, more qu- tions arose out of this discovery. What defnes a gene? What are the mechanisms of gene regulation? Further discovery and technological innovations brought about sequencing techniques that allowed the study of complete genomes from many organisms, including Arabidopsis and humans. Despite all the excitement surrounding these technologies, many features of the genome remained unclear. Peculiar characteristics in genome composition such as signifcant redundancy consisting of many repetitive elements and noncoding sequences, active transcriptional units with no protein product, and unusual sequences in promoter regions added to the mysteries of genetic make-up and gene regulation. Indeed, the more we discovered about the genome, the more diffcult it became to understand the complexity of cellular function and regulation. Out of the study of the intricacies of the genome and gene regulation, arose a new science that was independent of actual DNA changes, but critical in maintaining gene regulation and genetic stability. Epigenetics, literally translated as “above genetics,” is the science that describes the mechanisms of heritable changes in gene regulation that does not involve modifcations of DNA sequence. These changes may last through somatic cell division and, in some cases, throughout multiple generations.
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