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Toxicology of Glutathione Transferases, 


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Название:  Toxicology of Glutathione Transferases
ISBN: 9780367390532
Издательство: Taylor&Francis
Классификация:

ISBN-10: 0367390531
Обложка/Формат: Paperback
Страницы: 400
Вес: 0.74 кг.
Дата издания: 20.12.2019
Язык: English
Размер: 234 x 155 x 23
Читательская аудитория: Tertiary education (us: college)
Основная тема: Toxicology
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Европейский союз
Описание:

Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in all areas of GST research and have actively contributed to the progress of this field, the book describes the role of GSTs in toxicology, focusing on their pharmacologic and physiologic roles and their relevance to biological toxicology.

The book provides current information on gene families, structure and regulation of gene expression, reaction mechanisms and substrates, three-dimensional structures of GSTs, design of proteins with GST activity, and various approaches to developing inhibitors that overcome drug resistance. It also covers the physiological significance and the mechanisms of activation of microsomal GSTs. These topics, along with the role of GSTs in detoxification of chemical carcinogens and possible implications of GST polymorphism in human health and disease, make the volume useful to researchers in the field of pharmacology and toxicology.

Chapters cover the possible and exciting role of GSTs in defense mechanisms against chronic oxidative stress-linked disorders such as atherosclerosis and the newly emerging area of GST-mediated modulation of stress-signaling through its catalytic as well as binding activities. They explore an intriguing hypothesis that strongly suggests an important role of the factors that modulate the GSH-electrophile conjugate (GS-E) homeostasis in the regulation of cellular processes. Chapters on known and potential endogenous electrophilic substrates and a major role of GSTs in suppressing stress-induced lipid peroxidation reinforce this newly emerging role of GSTs. These are just a few of the features that make the book helpful to clinicians involved in basic as well as tr



Class 2 Transferases II

Автор: Dietmar Schomburg; A. Chang; Ida Schomburg
Название: Class 2 Transferases II
ISBN: 3642426662 ISBN-13(EAN): 9783642426667
Издательство: Springer
Рейтинг:
Цена: 279500.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized - and here is the second, updated edition. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index.

Class 2 Transferases X

Автор: Dietmar Schomburg; A. Chang; Ida Schomburg
Название: Class 2 Transferases X
ISBN: 3662500760 ISBN-13(EAN): 9783662500767
Издательство: Springer
Рейтинг:
Цена: 307450.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Springer Handbook of Enzymes provides data on enzymes sufficiently well characterized. It offers concise and complete descriptions of some 5,000 enzymes and their application areas. Data sheets are arranged in their EC-Number sequence and the volumes themselves are arranged according to enzyme classes. This new, second edition reflects considerable progress in enzymology: many enzymes are newly classified or reclassified. Each entry is correlated with references and one or more source organisms. New datafields are created: application and engineering (for the properties of enzymes where the sequence has been changed). The total amount of material contained in the Handbook has more than doubled so that the complete second edition consists of 39 volumes as well as a Synonym Index. In addition, starting in 2009, all newly classified enzymes are treated in Supplement Volumes. Springer Handbook of Enzymes is an ideal source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences, as well as for medicinal applications.

Class 2–3.2 Transferases, Hydrolases

Автор: Dietmar Schomburg; Ida Schomburg; Antje Chang
Название: Class 2–3.2 Transferases, Hydrolases
ISBN: 3642362397 ISBN-13(EAN): 9783642362392
Издательство: Springer
Рейтинг:
Цена: 330870.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Springer Handbook of Enzymes covers 5,000 enzymes and their applications. Data sheets are arranged in their EC-Number sequence and the volumes themselves are arranged according to enzyme classes. This volume covers Class 2-3.2 Transferases, Hydrolases.

Class 2 Transferases IV

Автор: Dietmar Schomburg; A. Chang; Ida Schomburg
Название: Class 2 Transferases IV
ISBN: 3662500736 ISBN-13(EAN): 9783662500736
Издательство: Springer
Рейтинг:
Цена: 260870.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Springer Handbook of Enzymes provides data on enzymes sufficiently well characterized. It offers concise and complete descriptions of some 5,000 enzymes and their application areas. Data sheets are arranged in their EC-Number sequence and the volumes themselves are arranged according to enzyme classes. This new, second edition reflects considerable progress in enzymology: many enzymes are newly classified or reclassified. Each entry is correlated with references and one or more source organisms. New datafields are created: application and engineering (for the properties of enzymes where the sequence has been changed). The total amount of material contained in the Handbook has more than doubled so that the complete second edition consists of 39 volumes as well as a Synonym Index. In addition, starting in 2009, all newly classified enzymes are treated in Supplement Volumes. Springer Handbook of Enzymes is an ideal source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences, as well as for medicinal applications.

Class 2 Transferases VIII

Автор: Dietmar Schomburg; A. Chang; Ida Schomburg
Название: Class 2 Transferases VIII
ISBN: 3662500787 ISBN-13(EAN): 9783662500781
Издательство: Springer
Рейтинг:
Цена: 260870.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Springer Handbook of Enzymes provides data on enzymes sufficiently well characterized. It offers concise and complete descriptions of some 5,000 enzymes and their application areas. Data sheets are arranged in their EC-Number sequence and the volumes themselves are arranged according to enzyme classes. This new, second edition reflects considerable progress in enzymology: many enzymes are newly classified or reclassified. Each entry is correlated with references and one or more source organisms. New datafields are created: application and engineering (for the properties of enzymes where the sequence has been changed). The total amount of material contained in the Handbook has more than doubled so that the complete second edition consists of 39 volumes as well as a Synonym Index. In addition, starting in 2009, all newly classified enzymes are treated in Supplement Volumes. Springer Handbook of Enzymes is an ideal source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences, as well as for medicinal applications.

Class 2 Transferases I

Автор: Antje Chang; Dietmar Schomburg; Ida Schomburg
Название: Class 2 Transferases I
ISBN: 364242161X ISBN-13(EAN): 9783642421617
Издательство: Springer
Рейтинг:
Цена: 231990.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized - and here is the second, updated edition. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index.

Functions of Glutathione in Liver and Kidney

Автор: H. Sies; A. Wendel
Название: Functions of Glutathione in Liver and Kidney
ISBN: 3642671349 ISBN-13(EAN): 9783642671340
Издательство: Springer
Рейтинг:
Цена: 121110.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The serene phrase, Lest I forget thee, glutathione ..., coined by the Kosowers (1) to describe the state in the 1960's, must be replaced now by something like "Inevitable GSH" in order to characterize the current situation. The surge in interest on the ubiquitous tripeptide has been ama- zing, with publications on GSH running at rates as high as one per day, so that it seemed appropriate to convene international experts for a discussion of recent develop- ments this year. Unlike the two previous meetings in this decade held in Tlibingen in 1973 (2) and in santa Ynez in 1975 (3), the scope was restricted to Functions of Gluta- thione in Liver and Kidney. Only in this way did an in-depth discussion of the current state of knowledge in a limit- ed topic appear possible. The last couple of years have seen a fascinating pro- ductivity in the fields of (a) Regulation of the Glutathione Level in the Liver, (b) Role of y-Glutamyltransferase in Gluta- thione Turnover with emphasis on the renal enzyme, and a critical appraisal of the y-Glutamyl Cycle, (c) Hyd: roperox- ide and Disulfide Metaholism, enriched by the discovery of the nonseleniurn-dependent glutathione peroxidase activ- ity and its relation to the glutathione-S-transferases, and the participation of the 2GSH/GSSG system in redox transitions in intact organ, cells and isolated mito- chondria, and (d) a multitude of Pharmacological and Toxi- cological Aspects related to glutathione, mainly centered on the events leading to liver damage and the protective

Class 2 Transferases V

Автор: Dietmar Schomburg; A. Chang; Ida Schomburg
Название: Class 2 Transferases V
ISBN: 3662518066 ISBN-13(EAN): 9783662518069
Издательство: Springer
Рейтинг:
Цена: 260870.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Springer Handbook of Enzymes provides data on enzymes sufficiently well characterized. It offers concise and complete descriptions of some 5,000 enzymes and their application areas. Data sheets are arranged in their EC-Number sequence and the volumes themselves are arranged according to enzyme classes. This new, second edition reflects considerable progress in enzymology: many enzymes are newly classified or reclassified. Each entry is correlated with references and one or more source organisms. New datafields are created: application and engineering (for the properties of enzymes where the sequence has been changed). The total amount of material contained in the Handbook has more than doubled so that the complete second edition consists of 39 volumes as well as a Synonym Index. In addition, starting in 2009, all newly classified enzymes are treated in Supplement Volumes. Springer Handbook of Enzymes is an ideal source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences, as well as for medicinal applications.


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