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DNA Methylation Microarrays, Wang, Sun-Chong , Petronis, Art


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Автор: Wang, Sun-Chong , Petronis, Art
Название:  DNA Methylation Microarrays
ISBN: 9780367387402
Издательство: Taylor&Francis
Классификация:
ISBN-10: 0367387409
Обложка/Формат: Paperback
Страницы: 256
Вес: 0.47 кг.
Дата издания: 20.12.2019
Язык: English
Размер: 234 x 155 x 15
Читательская аудитория: Professional & vocational
Основная тема: Bioinformatics
Подзаголовок: Experimental Design and Statistical Analysis
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Providing an interface between dry-bench bioinformaticians and wet-lab biologists, DNA Methylation Microarrays: Experimental Design and Statistical Analysis presents the statistical methods and tools to analyze high-throughput epigenomic data, in particular, DNA methylation microarray data. Since these microarrays share the same underlying principles as gene expression microarrays, many of the analyses in the text also apply to microarray-based gene expression and histone modification (ChIP-on-chip) studies.

After introducing basic statistics, the book describes wet-bench technologies that produce the data for analysis and explains how to preprocess the data to remove systematic artifacts resulting from measurement imperfections. It then explores differential methylation and genomic tiling arrays. Focusing on exploratory data analysis, the next several chapters show how cluster and network analyses can link the functions and roles of unannotated DNA elements with known ones. The book concludes by surveying the open source software (R and Bioconductor), public databases, and other online resources available for microarray research.

Requiring only limited knowledge of statistics and programming, this book helps readers gain a solid understanding of the methodological foundations of DNA microarray analysis.



Microarrays for Integrative Genomics

Автор: Kohane, Isaac S.
Название: Microarrays for Integrative Genomics
ISBN: 026211271X ISBN-13(EAN): 9780262112710
Издательство: MIT Press
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Цена: 16140.00 T
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Описание: Functional genomics - the decontruction of the genome to determine the biological function of genes and gene interactions - is a growing area of biology. This volume provides a systematic introduction to the use of DNA microarrays as an investigative tool for functional genomics.

DNA Methylation: Principles, Mechanisms & Challenges

Автор: Tatiana V Tatarinova, Gaurav Sablok
Название: DNA Methylation: Principles, Mechanisms & Challenges
ISBN: 1624171281 ISBN-13(EAN): 9781624171284
Издательство: Nova Science
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Цена: 224920.00 T
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Описание: DNA methylation is a cryptic phenomenon that invokes the methylation of the cytosines in nuclear DNA and is responsible for a wide variety of essential processes, starting from cellular differentiation (embryogenesis), transposon silencing, miRNA dependent methylation and gene regulation. This book presents an overview of different aspects of DNA methylation with a focus on its basic principles and mechanisms and gene silencing. Also discussed, is the role of DNA methylation in plants; epigenetic control of circadian clock operation; photoperiodic flowering; and DNA methylation in cancer and its role in multiple sclerosis.

DNA Methylation: Principles, Methods and Mechanisms

Автор: Malcolm Billy
Название: DNA Methylation: Principles, Methods and Mechanisms
ISBN: 168286412X ISBN-13(EAN): 9781682864128
Издательство: Неизвестно
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Цена: 161990.00 T
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Описание: DNA Methylation can be defined as the method by which methyl groups act on the DNA in order to repress cell processes. DNA methylation is vital for the organic processes taking place inside the human body such as ageing, carcinogenesis and gene expression. The aim of this book is to present researchers that have transformed this discipline and added its advancement. From theories and research to practical applications, case studies related to all contemporary topics of relevance to this field have been included herein. This book will prove useful for students as well as experts in the fields of evolutionary biology, bioengineering, and biochemistry. It is an essential guide for both academicians as well as for those who wish to pursue this discipline further.

DNA Microarrays: Gene Expression Applications

Автор: B.R. Jordan
Название: DNA Microarrays: Gene Expression Applications
ISBN: 3540415084 ISBN-13(EAN): 9783540415084
Издательство: Springer
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Цена: 71730.00 T
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Описание: A practical manual on expression measurement using DNA arrays. It covers various methods (from nylon macroarrays to oligonucleotide chips) and includes detailed protocols. It also covers software, data mining procedures and probable future developments.

DNA Microarrays and Related Genomics Techniques

Автор: Allison
Название: DNA Microarrays and Related Genomics Techniques
ISBN: 0824754611 ISBN-13(EAN): 9780824754617
Издательство: Taylor&Francis
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Цена: 137810.00 T
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Описание: Explores critical aspects of designing a microarray experiment, including power and sample size. This book assesses the validity of statistical methods and describes how to ensure the quality and integrity of data. It discusses methods for interpreting microarray data and examines the various issues associated with analysis.

Microarrays: Principles, Applications & Technologies

Автор: James V Rogers
Название: Microarrays: Principles, Applications & Technologies
ISBN: 1629486698 ISBN-13(EAN): 9781629486697
Издательство: Nova Science
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Цена: 205910.00 T
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Описание: The sequencing of the human genome was a pivotal event in science that opened the door to exploring the structure and function of genes and their regulation. The activation or suppression of transcribed genes is critical to the orchestration of everyday biological processes at the cellular, tissue, and physiological levels. The rapid advance of science and technology has yielded the development of the microarray technique, which has propelled a much deeper understanding of the genome. By combining these technological advances in microarrays with statistical and bioinformatics software, investigators are now able to perform scientific investigations geared towards answering unique biological problems that encompass many fields of research from genetics and evolution to molecular medicine, health, and disease. This book provides an overview of the use and application of microarrays throughout the life sciences to address diverse complex biological questions. In this collection, authors present information on using microarrays to unlock molecular mechanisms and gene expression patterns associated with research areas ranging from biodefense, pathological changes, and monitoring antimicrobial resistance genes to diagnostics, marine biodiversity, and dermal toxicology.


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