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Combinatorial Synthesis of Natural Product-Based Libraries, 


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Название:  Combinatorial Synthesis of Natural Product-Based Libraries
ISBN: 9780367453626
Издательство: Taylor&Francis
Классификация:


ISBN-10: 0367453622
Обложка/Формат: Paperback
Страницы: 362
Вес: 0.67 кг.
Дата издания: 29.11.2019
Язык: English
Иллюстрации: 20 tables, black and white; 3 halftones, black and white; 247 illustrations, black and white
Размер: 210 x 150 x 22
Основная тема: Medicinal & Pharmaceutical Chemistry
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinatorial Synthesis of Natural Product-Based Libraries summarizes the most important perspectives on the application of combinatorial chemistry and natural products to novel drug discovery.

The book details the latest approaches for implementing combinatorial research and testing methodologies to the synthesis of natural product-based libraries. Interconnecting the important aspects of this emerging field through the work of several leading scientists, it covers the computational analysis of natural molecules and details strategies for designing compound libraries, using bioinformatics in particular. The authors describe numerous synthetic methods for producing natural products and their analogs, including engineered biosynthesis and polymer-supported reagents. They also discuss additional considerations for generating libraries, such as screening, scaffolding, and yield optimization. Other chapters examine specific classes of libraries derived from natural products including carbohydrates, polyketides, peptides, alkaloids, terpenoids, steroids, flavonoids, and fungal compounds.

Drawing attention to the interplay of drug discovery, natural products, and organic synthesis, Combinatorial Synthesis of Natural Product-Based Libraries contains the most recent and significant methods used to search and assess new compounds for their ability to mitigate biological processes that may lead to improved treatments for various diseases.



Total Synthesis of Natural Products

Автор: Li
Название: Total Synthesis of Natural Products
ISBN: 3642340644 ISBN-13(EAN): 9783642340642
Издательство: Springer
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Цена: 65210.00 T
Наличие на складе: Есть
Описание: Written by experts in organic chemistry, this book covers a range of natural products, from steroids to alkaloids. Coverage details the biological and pharmacological properties of the natural product and outlines current total synthesis procedures.

Selectivity in the Synthesis of Cyclic Sulfonamides

Автор: Kimberly Geoghegan
Название: Selectivity in the Synthesis of Cyclic Sulfonamides
ISBN: 3319103377 ISBN-13(EAN): 9783319103372
Издательство: Springer
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Цена: 104480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: We discovered an interesting regioselectivity in an intramolecular Heck reaction, which we studied for a series of substrates that are unbiased in terms of the size of the newly formed ring, where very high levels of selectivity in relation to the new carbon-carbon bond are typically observed.

Synthesis of Marine Natural Products 2

Автор: K.F. Albizati; V.A. Martin; M.R. Agharahimi; D.A.
Название: Synthesis of Marine Natural Products 2
ISBN: 3642768407 ISBN-13(EAN): 9783642768408
Издательство: Springer
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Цена: 121110.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Volumes five and six of Bioorganic Marine Chemistry differ from their predecessors in two respects - they deal exclusively with laboratory synthesis of marine natural products and they represent the effort of a single author and his associates.

Synthesis of Marine Natural Products 1

Автор: K.F. Albizati; V.A. Martin; M.R. Agharahimi; D.A.
Название: Synthesis of Marine Natural Products 1
ISBN: 3642768377 ISBN-13(EAN): 9783642768378
Издательство: Springer
Рейтинг:
Цена: 121110.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Volumes five and six of Bioorganic Marine Chemistry differ from their predecessors in two respects - they deal exclusively with labor- atory synthesis of marine natural products and they represent the effort of a single author and his associates.

Total Synthesis of Bioactive Natural Products

Автор: Brahmachari, Goutam
Название: Total Synthesis of Bioactive Natural Products
ISBN: 0081028229 ISBN-13(EAN): 9780081028223
Издательство: Elsevier Science
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Цена: 174050.00 T
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Описание:

Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background outlining the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making Total Synthesis of Bioactive Natural Products an essential and practical guide for all those working with both synthesis and natural products, and an inspirational source of novel structures.

  • Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules
  • Outlines each step of the process in detail with full experimental information supported by extensive schemes
  • Includes retrosynthetic analyses, reaction sequences, and stereochemically crucial steps for each molecule

Graphene from natural sources

Автор: Al-ahmed, Amir (corere, King Fahd University Of Petroleum & Minerals, Saudi Arabia) Inamuddin
Название: Graphene from natural sources
ISBN: 0367770911 ISBN-13(EAN): 9780367770914
Издательство: Taylor&Francis
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Цена: 173530.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Examines the synthesis of graphene obtained from different natural raw materials as a low-cost environmentally friendly alternative that delivers a quality final product. Expert researchers review natural raw materials and waste product potential, methods of characterization, graphene synthesis considerations and important applications.

Total Synthesis of Natural Products

Автор: Jie Jack Li; E.J. Corey
Название: Total Synthesis of Natural Products
ISBN: 3642440924 ISBN-13(EAN): 9783642440922
Издательство: Springer
Рейтинг:
Цена: 102480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

NOVEL METHODS FOR PYRROLE SYNTHESIS: Application in Total Synthesis of Marine Natural Products

Автор: Paulson Mathew
Название: NOVEL METHODS FOR PYRROLE SYNTHESIS: Application in Total Synthesis of Marine Natural Products
ISBN: 384336365X ISBN-13(EAN): 9783843363655
Издательство: LAP LAMBERT Academic Publishing
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Цена: 94370.00 T
Наличие на складе: Нет в наличии.

Selectivity in the Synthesis of Cyclic Sulfonamides

Автор: Kimberly Geoghegan
Название: Selectivity in the Synthesis of Cyclic Sulfonamides
ISBN: 3319364316 ISBN-13(EAN): 9783319364315
Издательство: Springer
Рейтинг:
Цена: 87060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: We discovered an interesting regioselectivity in an intramolecular Heck reaction, which we studied for a series of substrates that are unbiased in terms of the size of the newly formed ring, where very high levels of selectivity in relation to the new carbon-carbon bond are typically observed.

Total Synthesis of Natural Products with Antimicrobial Activity

Автор: Giltrap
Название: Total Synthesis of Natural Products with Antimicrobial Activity
ISBN: 9811088055 ISBN-13(EAN): 9789811088056
Издательство: Springer
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Цена: 121110.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

Natural Product Synthesis II

Автор: Johann H. Mulzer; U. Beifuss; T.J. Heckrodt; M. Ka
Название: Natural Product Synthesis II
ISBN: 3642059325 ISBN-13(EAN): 9783642059322
Издательство: Springer
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Цена: 287330.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.

A-tertiary amines en route to natural products

Автор: Hameed, Abdul (h.e.j. Research Institute Of Chemistry, International Center For Chemical And Biological Sciences, University Of Karachi, Karachi, Paki
Название: A-tertiary amines en route to natural products
ISBN: 012822262X ISBN-13(EAN): 9780128222621
Издательство: Elsevier Science
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Цена: 129130.00 T
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Описание:

α-Tertiary Amines en Route to Natural Products presents the multistep synthesis of natural products using schematic diagrams. This approach provides a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. The book covers the class of natural products bearing the α,α-disubstituted α-amino acid motif. Featured natural product molecules include Altemicidin, Amathaspiramide (A-F), Kaitocephalin, Lactacystin, Salinosporamide, Manzacidins (A, C), Neooxazolomycin, Sphingofungins (E, F), (1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid (ACPD), Total synthesis of cephalotaxine and related molecules, α-amino acids based natural products, α amino acid based natural products and Tetrodotoxin.

This book is ideal for chemists working in the area of organic synthesis, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis.


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