Toxicokinetics and Risk Assessment, 

Автор: Lipscomb John C
Название: Toxicokinetics Risk Assessment
ISBN: 0849337224 ISBN-13(EAN): 9780849337222
Издательство: Taylor&Francis
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Цена: 183750.00 T
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Описание: Toxicokinetics in Risk Assessment discusses the noncancer risk assessment process and its reliance on uncertainty factors in order to facilitate the continued study and refinement of the scientific basis for health risk assessment. This text clearly demonstrates the application of physiologically-based pharmacokinetic (PBPK) modeling in human health risk assessment, as well as methods for data generation, extrapolation, and inclusion of laboratory results for chemical metabolism and computer-based predictions of biochemical constants to address estimates of variability between experimental animals and humans. This guide also includes recent examples of the use of toxicokinetic information to successfully replace default values for uncertainty factors with data-derived factors in risk assessments developed by the US Environmental Protection Agency.

Автор: J. Kr?se; H. Verhaar; W.K. de Raat
Название: The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals
ISBN: 9048161479 ISBN-13(EAN): 9789048161478
Издательство: Springer
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Цена: 130590.00 T
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Описание: In 2000 OpdenKamp Registration & Notification organized a two-day symposium in The Hague, The Netherlands, on The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals'. Several speakers from Europe and the United States were invited to present the different aspects. A vast range of areas was discussed in relation to toxicological modeling and risk assessment, such as occupational toxicology and biomonitoring, exposure to organic solvents and crop protection products, dose-response relations in carcinogenicity, regulatory toxicology, estimation of dermal penetration, uptake and disposition of organic chemicals in fish, the possibilities of in vitro methods in hazard and risk assessment, and the extrapolation between animal and human species. Based on their presentations, the speakers prepared comprehensive papers for this symposium book, reflecting the state of the art of modeling and toxicological risk assessment at the beginning of the third millennium.

Автор: A. Yacobi; J.P. Skelly; Vinod P. Shah; L.Z. Benet
Название: Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development
ISBN: 1475715226 ISBN-13(EAN): 9781475715224
Издательство: Springer
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Цена: 104480.00 T
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Описание: Proceedings of a conference sponsored by the American Association of Pharmaceutical Scientists, the U.S. Food and Drug Administration, and the American Society for Clinical Pharmacology and Therapeutics, held in Arlington, Virginia, April 24-26, 1991