Автор: Randall J. Mrsny, Ann Daugherty Название: Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes ISBN: 1420078062 ISBN-13(EAN): 9781420078060 Издательство: Taylor&Francis Рейтинг: Цена: 128620.00 T Наличие на складе: Есть Описание: Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.
Key features include:
issues related to delivery of protein and peptide therapeutics in elderly populations and pharmacogenomics
lessons learned on the major marketed areas of proteins and peptides, including interleukins, interferons, growth factors, and peptide hormones
innovations for protein and peptide delivery such as needle-less delivery
strategies for delivery of these molecules to locations such as the eye and brain
generic issues of proteins and peptides
Автор: David R. Brown; A. Alemayehu; B. Amiranoff; D.L. B Название: Gastrointestinal Regulatory Peptides ISBN: 364277816X ISBN-13(EAN): 9783642778162 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Authored by an array of internationally distinguished scientists, it deals with issues of peptide localization and biosynthesis in gastrointestinal cells, mechanisms of peptide release and inactivation and the nature of peptide receptors.
Автор: Martin C. Michel Название: Neuropeptide Y and Related Peptides ISBN: 3642622828 ISBN-13(EAN): 9783642622823 Издательство: Springer Рейтинг: Цена: 279500.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: with contributions by numerous experts
Автор: Theodor Wieland Название: Peptides of Poisonous Amanita Mushrooms ISBN: 3642712975 ISBN-13(EAN): 9783642712975 Издательство: Springer Рейтинг: Цена: 113190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: We have learned a great deal about the chemical and physical nature of the macro- molecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller molecules work together to provide the molecular setting of living systems.
Автор: Dietmar Richter Название: Regulatory Peptides and Cognate Receptors ISBN: 3540653252 ISBN-13(EAN): 9783540653257 Издательство: Springer Рейтинг: Цена: 297210.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Since the 1980s, our knowledge of regulatory peptides and their cognate receptors has greatly increased. This text discusses various peptide receptor systems, for example CRF, somatostatin, TRH, opioid peptides and vasopressin, and strategies for uncovering new peptides are examined.
Автор: Dietmar Richter Название: Regulatory Peptides and Cognate Receptors ISBN: 3662129086 ISBN-13(EAN): 9783662129081 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In the last two decades, our knowledge on regulatory peptides and their cognate receptors, most of which are members of the seven transmembrane receptor families, has increased enormously. Regulatory peptides are small proteins which, besides their hormonal functions in regulating cellular metabolism in various tissues, may also act as neurotransmitters, and thus they often carry the prefix "neuro". Many of the cognate receptors involved in transducing the peptidergic signal across the cell membrane via a family of G proteins exist in multiple forms, the number of which frequently exceeds that of the corresponding peptide ligands. In this book, various peptide-receptor systems are discussed, e.g. CRF, somatostatin, TRH, opioid peptides, vasopressin, and oxytocin. It also discusses new strategies such as "reverse physiology" to uncover new peptides and orphan receptors.
Автор: Willis K. Samson; Ellis Levin Название: Natriuretic Peptides in Health and Disease ISBN: 1461284414 ISBN-13(EAN): 9781461284413 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A comprehensive, state-of-the-art review of the biochemistry, molecular and cellular biology, pharmacology, physiology, and pathology of natriuretic peptides.
Автор: Hovgaard, Lars Название: Pharmaceutical Formulation Development of Peptides and Proteins ISBN: 1439853886 ISBN-13(EAN): 9781439853887 Издательство: Taylor&Francis Рейтинг: Цена: 193950.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Название: Proinflammatory and Antiinflammatory Peptides ISBN: 0367400677 ISBN-13(EAN): 9780367400675 Издательство: Taylor&Francis Рейтинг: Цена: 42870.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: "Analyzes the role of peptides in promoting or suppressing inflammation. Thoroughly examines the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair."
Автор: Tyagi, Puneet Название: Oral Delivery Of Therapeutic Peptides And Proteins ISBN: 0128210613 ISBN-13(EAN): 9780128210611 Издательство: Elsevier Science Рейтинг: Цена: 174050.00 T Наличие на складе: Нет в наличии. Описание: Luckily, the parking lot only deleted footage every three months because of the relatively heavy flow of tourism that took place at Cramond Ghost Island during the summer months. The old man in charge of the parking lot security cameras asked us why we needed the footage. Ethan told him that I met someone there at noon on a Saturday in July and that the police needed to verify that this meeting took place on that date. The old man had to review footage of the four Saturdays in July. He grumbled as he escorted us to a small viewing room at the rear end of the parking lot. Ethan and I sat down next to the old man as he began his search. He
Автор: Langel, Ulo , Cravatt, Benjamin F. , Graslund, A Название: Introduction to Peptides and Proteins ISBN: 0367384876 ISBN-13(EAN): 9780367384876 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform researchers and students in all of those fields now concerned with protein research.
Introduction to Peptides and Proteins brings together some of the most respected researchers in protein science to present a remarkably coherent introduction to modern peptide and protein chemistry. The first sections of the book delve into -
Basic peptide and protein science from assembly through degradation
Traditional and emerging research methods including those used in bioinformatics and proteomics
New computational approaches and algorithms used to find patterns in the vast data collected by sequencing projects
After providing a foundation in tools and methods, the authors closely examine six protein families, including representative classes such as enzymes, cell-surface receptors, antibodies, fibrous proteins, and bioactive peptide classes. They concentrate on biochemical mechanisms and where possible indicate therapeutic or biotechnical possibilities.
Then focusing on clinical aspects, the authors investigate misfolding as found in prion diseases, miscleavage as found in Alzheimer's, and mis-sequencing as found with some cancers. Drawing from some of their own research, the authors summarize recent achievements and emerging applications. They discuss the use of proteins and peptides as drugs and the solid-phase synthesis required for drug production. They also look at the use of peptides as functional biomolecules and research tools.
No longer just th
Автор: K.O. Stumpe; Karin Kraft; Alan I. Faden Название: Opioid Peptides and Blood Pressure Control ISBN: 3540189351 ISBN-13(EAN): 9783540189350 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A. , FADEN, K. KRAFr, and K. O. STUMPE Following the discovery of the pentapeptide enkephalins in 1975, a number of endogenous opioid peptides and opiate receptors have been identified. Endogenous opioids and opiate-receptor mechanisms have been implicated in a variety of regulat- ory and dysregulatory functions including analgesia, cardiovascular regulation, shock, hypertension, traumatic spinal cord and brain injury, stroke, immune func- tion, feeding behavior, diuresis, gastrointestinal motility, and respiratory control, among others. Over the past 10 years, many studies have demonstrated a relationship between endogenous opioids and the cardiovascular system under both homeostatic and pathophysiological conditions. Opioids and opiate receptors have been found in various cardioregulatory sites within the brain and spinal cord, as well as in peripheral tissues such as sympathetic ganglia, adrenal gland, and heart. Both endogenous opioids and exogenous opiates have been shown to produce potent cardiovascular effects following central nervous system or systemic administration. Opiate-receptor antagonists have been demonstrated to reverse hypotension from sepsis, hypo- volemia, and anaphylaxis; such studies have been used to infer activity of endogenous opioid systems in shock. Changes in tissue concentrations of endogenous opioids and or opiate receptors have been found after shock and hypertension, further implying a role for opioid systems in the etiology of these conditions. In addition, modification of opiate receptor regulation, receptor binding, or opioid metabolism has also been used to establish a potential role for endogenous opioid systems in cardiovascular control and dyscontrol.
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