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Chemistry and Molecular Aspects of Drug Design and Action, 


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Название:  Chemistry and Molecular Aspects of Drug Design and Action
ISBN: 9780367387365
Издательство: Taylor&Francis
Классификация:


ISBN-10: 0367387360
Обложка/Формат: Paperback
Страницы: 380
Вес: 1.55 кг.
Дата издания: 27.09.2019
Язык: English
Размер: 231 x 155 x 20
Читательская аудитория: Tertiary education (us: college)
Основная тема: Medicinal & Pharmaceutical Chemistry
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Европейский союз
Описание: An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to develop pharmacophores, and further optimization to produce the best compounds.

Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design. Offering insight from their own specialized research, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks.

Divided into five parts, each dedicated to various aspects of the classical medicinal chemistry approach, the text makes it easy for readers to focus on a field of specific interest.

  • Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions
  • Classical Medicinal Chemistry
  • Drug Design, Chemical and Molecular Aspects of Drug Action
  • Drug Xenobiotic Metabolism
  • Physical Organic and Theoretical Medicinal Chemistry
  • While each section can be studied independently, the combined material in this volume provides the most comprehensive overview available on rational drug design. This work is an invaluable resource both for those entering the field, as well as those researchers looking to b


    The Organic Chemistry of Drug Design and Drug Action,

    Автор: Richard B. Silverman
    Название: The Organic Chemistry of Drug Design and Drug Action,
    ISBN: 0123820308 ISBN-13(EAN): 9780123820303
    Издательство: Elsevier Science
    Рейтинг:
    Цена: 88690.00 T
    Наличие на складе: Есть у поставщика Поставка под заказ.
    Описание:

    The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules.

    This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage.

    This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries.

    Drug Design and Action

    Автор: Joaquin M. Campos Rosa, M. Encarnacion Camacho Quesada
    Название: Drug Design and Action
    ISBN: 3110528363 ISBN-13(EAN): 9783110528367
    Издательство: Walter de Gruyter
    Цена: 74320.00 T
    Наличие на складе: Невозможна поставка.
    Описание: This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 1 introduces the concepts of drug design and drug metabolic processes as well as antibacterial, antiviral and anticancer agents.

    Drug Transporters: Volume 2: Recent Advances and Emerging Technologies

    Автор: Nicholls Glynis, Youdim Kuresh, Fox David
    Название: Drug Transporters: Volume 2: Recent Advances and Emerging Technologies
    ISBN: 1782628665 ISBN-13(EAN): 9781782628668
    Издательство: Royal Society of Chemistry
    Рейтинг:
    Цена: 223870.00 T
    Наличие на складе: Есть у поставщика Поставка под заказ.
    Описание: This book comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics.

    Drug Transporters: Role and Importance in Adme and Drug Development Complete Set

    Автор: Nicholls Glynis, Youdim Kuresh, Fox David
    Название: Drug Transporters: Role and Importance in Adme and Drug Development Complete Set
    ISBN: 1782628673 ISBN-13(EAN): 9781782628675
    Издательство: Royal Society of Chemistry
    Рейтинг:
    Цена: 422400.00 T
    Наличие на складе: Есть у поставщика Поставка под заказ.
    Описание: Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. This two volume set of books comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. The second volume is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in this set of books ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

    Drug Discovery for Leishmaniasis

    Название: Drug Discovery for Leishmaniasis
    ISBN: 1782628894 ISBN-13(EAN): 9781782628897
    Издательство: Royal Society of Chemistry
    Рейтинг:
    Цена: 209790.00 T
    Наличие на складе: Есть у поставщика Поставка под заказ.
    Описание: Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania.

    General and Molecular Pharmacology: Principles of Drug Action

    Автор: Francesco Clementi,Guido Fumagalli
    Название: General and Molecular Pharmacology: Principles of Drug Action
    ISBN: 1118768574 ISBN-13(EAN): 9781118768570
    Издательство: Wiley
    Рейтинг:
    Цена: 134060.00 T
    Наличие на складе: Есть у поставщика Поставка под заказ.
    Описание: With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with a particular attention to the mechanisms of drug action the fundamental basis for proper clinical use without neglecting toxicology and pharmacokinetics.

    Antibiotic Drug Discovery: New Targets and Molecular Entities

    Название: Antibiotic Drug Discovery: New Targets and Molecular Entities
    ISBN: 1782624244 ISBN-13(EAN): 9781782624240
    Издательство: Royal Society of Chemistry
    Рейтинг:
    Цена: 237950.00 T
    Наличие на складе: Есть у поставщика Поставка под заказ.
    Описание: This book identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities.

    Drug Transporters: Volume 1: Role and Importance in Adme and Drug Development

    Автор: Nicholls Glynis, Youdim Kuresh, Fox David
    Название: Drug Transporters: Volume 1: Role and Importance in Adme and Drug Development
    ISBN: 1782620699 ISBN-13(EAN): 9781782620693
    Издательство: Royal Society of Chemistry
    Рейтинг:
    Цена: 252030.00 T
    Наличие на складе: Есть у поставщика Поставка под заказ.
    Описание: This book comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics.


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