This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Chris Gehring Название: Cyclic Nucleotide Signaling in Plants ISBN: 1627034404 ISBN-13(EAN): 9781627034401 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book details approaches to better understand signal transduction and the molecular mechanisms underlying cellular signaling. It features step-by-step, readily reproducible laboratory protocols as well as lists of the necessary materials and reagents.
Автор: Horst Sund Название: Pyridine Nucleotide-Dependent Dehydrogenases ISBN: 3642499767 ISBN-13(EAN): 9783642499760 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The present volume represents the proceedings of the symposium on npyridine Nucleotide-Dependent Dehydrogenases" which was held on the campus of the re- cently established University of Konstanz, Germany, from September 15 to 20, 1969.
Автор: David Crich Название: Reagents for Glycoside, Nucleotide, and Peptide Synthesis ISBN: 047002304X ISBN-13(EAN): 9780470023044 Издательство: Wiley Рейтинг: Цена: 164680.00 T Наличие на складе: Поставка под заказ. Описание: The Synthesis of biopolymers and their conjugates is of ever increasing importance in bioorganic chemistry and chemical biology. As the need for such systems becomes ever more widespread, their synthesis is necessarily practiced in a broader spectrum of laboratories beyond the specialized ones that have traditionally concentrated in the area.
Автор: John T. Turner; Gary A. Weisman; Jeffrey S. Fedan Название: The P2 Nucleotide Receptors ISBN: 1461272890 ISBN-13(EAN): 9781461272892 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors.
Автор: L. Bosch Название: The Guanine — Nucleotide Binding Proteins ISBN: 1475720394 ISBN-13(EAN): 9781475720396 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume contains the proceedings of the EMBO-NATO-CEC Advanced Research Workshop on "Guanine-nucleotide binding proteins. The cellular membrane, as the obligatory target for external signals, harbours complex pathways transducing the signals from the receptors of the external stimuli to the cytoplasmic effector.
Название: Cyclic Nucleotide Phosphodiesterases in Health and Disease ISBN: 0367453320 ISBN-13(EAN): 9780367453329 Издательство: Taylor&Francis Рейтинг: Цена: 63280.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.
Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe one of the 11 known mammalian PDE families including the molecular characteristics, structure, function, and traits unique to each. Characteristics of PDEs from lower organisms are also the subject of other chapters since they provide key insights into PDE functions and are also pharmacological targets for treatment of a variety of diseases in humans and domestic animals. Chapters on the current biomedical and therapeutic research on PDEs include studies on gene-targeted knockout strategies and compartmentation in cyclic nucleotide signaling. By unraveling the unique cellular roles for different PDEs, scientists are beginning to open the door to the therapeutic use of PDE inhibitors for the treatment of a number of pathological conditions including asthma and inflammation, pulmonary hypertension, erectile dysfunction, and stroke.
By collating current information into a coherent and coordinated perspective, Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an invaluable reference for industry and clinical scientists and points toward future directions of research and therapeutic advancements in developing selective inhibitors for these various enzymes.
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