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The Pharmacological Guide to Metformin, Natalie Lajoie


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Автор: Natalie Lajoie
Название:  The Pharmacological Guide to Metformin
ISBN: 9781536166347
Издательство: Nova Science
Классификация:
ISBN-10: 1536166340
Обложка/Формат: Paperback
Страницы: 248
Вес: 0.49 кг.
Дата издания: 16.12.2019
Серия: Medicine
Язык: English
Размер: 239 x 160 x 22
Ключевые слова: Pharmacology
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Поставляется из: Англии
Описание: Almost six decades after its discovery, metformin still remains the gold standard drug for the management of type 2 diabetes mellitus, owing to its euglycemic property and cost-effectiveness. It is the most commonly prescribed and utilized oral antidiabetic drug worldwide. However, no two persons with the same phenotypical characteristics, such as age, gender, body weight and others, tend to respond similarly to equivalent doses of metformin. As such, The Pharmacological Guide to Metformin first focuses on the various genetic polymorphisms that influence the therapeutic effects of metformin. Physicochemical, pharmacological, and pharmacokinetic properties of metformin will also be reviewed. The side effects of this drug can be dangerous. Metformin-induced lactic acidosis is a lethal disorder. The first significant deviation is gastrointestinal tract involvement. Common infection or the effect of metformin itself causes vomiting and diarrhea, with subsequent hypovolemia causing pre-renal acute kidney injury, which in turn raises metformin levels up to toxic values. Development of kidney failure is often unexpected and fast. Following this, the authors explore the differences between healthy and cancer cells and how this may influence the metformin effect on these cells. In conclusion, the molecular mechanisms underlying the anticancer effects of metformin in breast and ovarian cancers are summarized, and the potential anticancer applications of metformin-based combinatorial chemotherapy are discussed.

Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies (Second Edition)

Автор: Scherman Daniel
Название: Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies (Second Edition)
ISBN: 1786346877 ISBN-13(EAN): 9781786346872
Издательство: World Scientific Publishing
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Цена: 221760.00 T
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Описание:

This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.

The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.

This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.


Goodman And Gilman`s Pharmacological Basis Of Therapeutics 12 ed

Автор: Laurence Brunton, Bruce Chabner
Название: Goodman And Gilman`s Pharmacological Basis Of Therapeutics 12 ed
ISBN: 0071624422 ISBN-13(EAN): 9780071624428
Издательство: McGraw-Hill
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Цена: 116690.00 T
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Описание: A medical text that represents accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. It helps thousands of practitioners and students to an understanding of the drugs essential to preventing, diagnosing, and treating disease.

Goodman and Gilman`s The Pharmacological Basis of Therapeutics, 13th Edition

Автор: Brunton, Laurence; Knollmann, Bjorn; Hilal-Dandan, Randa
Название: Goodman and Gilman`s The Pharmacological Basis of Therapeutics, 13th Edition
ISBN: 1259584739 ISBN-13(EAN): 9781259584732
Издательство: McGraw-Hill
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Цена: 0.00 T
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Описание: The gold-standard of pharmacology texts - updated to reflect the latest developments and breakthroughs

Calcitonins — Physiological and Pharmacological Aspects. Mafosfamide — A Derivative of 4-Hydroxycyclophosphamide. Enzymatic DNA Methylation

Автор: M. Azria; J. Engel; S. Gr?nwald; P. Hilgard; U. Ni
Название: Calcitonins — Physiological and Pharmacological Aspects. Mafosfamide — A Derivative of 4-Hydroxycyclophosphamide. Enzymatic DNA Methylation
ISBN: 3642747361 ISBN-13(EAN): 9783642747366
Издательство: Springer
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Цена: 121110.00 T
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Описание: Das Buch enthalt Kapitel uber: M. Azria, Basel, CH: "Calcitonin - Physiologische und Pharmakologische Aspekte"U. Niemeyer, J. Engel, P. Hilgard, M. Peukert, J. Pohl, H. Sindermann, Bielefeld, FRG: "Mafosfamid - Ein Derivat des " "4-Hydroxycyclophosphamids"S. Grunwald, G.P. Pfeifer, Frankfurt, FRG: "Enzymatische DNA Methylierung"

The Pharmacological Guide to Haloperidol

Автор: Amor Harland
Название: The Pharmacological Guide to Haloperidol
ISBN: 1536147001 ISBN-13(EAN): 9781536147001
Издательство: Nova Science
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Цена: 103480.00 T
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Описание: Haloperidol is the most common neuroleptic drugs associated with a range of side effects caused by interactions with other drugs. In The Pharmacological Guide to Haloperidol, the authors review cases that report common pharmacodynamic and pharmacokinetic drug interactions of haloperidol in vivo. Next, this compilation investigates methods for the determination of haloperidol in body fluids such as blood, urine and cerebral spinal fluid. Several techniques discussed include magnetic resonance spectroscopy, spectrophotometry and high performance liquid chromatography. Also included is a description of haloperidol derivatives and their applications as antimicrobial agents, vasodilators and calcium channel blockers. Additionally, haloperidol derivatives that have potential applications for improving cardiac function and reducing oxidative stress are also addressed. The authors present some studies which use functional magnetic resonance imaging to study aspects of haloperidol on facial expressions. Emotion processing is often notable in neurodegenerative diseases such as schizophrenia and evaluated in cerebral blood flow response in diseased patients. The following chapter focuses on a literature analysis of the use of haloperidol, with studies indicating a potential limit for haloperidol efficacy; values above this limit dont appear to provid any supplementary clinical improvement. Lastly, the authors provide a review of studies that have used magnetic resonance imaging to monitor haloperidol in vivo. Applications of 1H and 19F MRI in drug monitoring are discussed and a list of relevant studies is presented.

Pharmacological Aspects of Drug Dependence

Автор: Charles R. Schuster; Michael J. Kuhar
Название: Pharmacological Aspects of Drug Dependence
ISBN: 364264631X ISBN-13(EAN): 9783642646317
Издательство: Springer
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Цена: 113190.00 T
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Описание: With contributions by numerous experts

Pharmacological Considerations in Gerontology: A Patient-Centered Guide for Advanced Practice Registered Nurses and Related Health Professions

Автор: Abimbola Farinde, Megan Hebdon
Название: Pharmacological Considerations in Gerontology: A Patient-Centered Guide for Advanced Practice Registered Nurses and Related Health Professions
ISBN: 082612769X ISBN-13(EAN): 9780826127693
Издательство: Mare Nostrum (Eurospan)
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Цена: 58520.00 T
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Описание: Underscores the complexity of prescribing drugs for older adults while providing state-of-the-art guidelines for safe patient care. An evidence-based, quick-access reference for adult gerontology nurse practitioners and related providers, this text describes a holistic, patient-centered approach to prescribing drugs to older adults.

Pharmacological Treatment of Chronic Stable Angina Pectoris

Автор: Pablo Avanzas; Juan Carlos Kaski
Название: Pharmacological Treatment of Chronic Stable Angina Pectoris
ISBN: 3319173316 ISBN-13(EAN): 9783319173313
Издательство: Springer
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Цена: 46570.00 T
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Описание: This book is intended for general cardiologists and other physicians involved in the care of patients with chronic stable angina (CSA). The management of these patients encompasses lifestyle modification, control of coronary artery disease risk factors, evidence-based pharmacological therapy and patient education.

The Pharmacological Guide to Montelukast

Автор: SA,ren C. Dam
Название: The Pharmacological Guide to Montelukast
ISBN: 1536163945 ISBN-13(EAN): 9781536163940
Издательство: Nova Science
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Цена: 77080.00 T
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Описание: The Pharmacological Guide to Montelukast opens by presenting the most recent updates on the improvement of montelukast stability and bioavailability, along with some innovative formulations produced by this research. Montelukast is a leukotriene modifier with bronchoprotective and anti-inflammatory actions frequently used in asthma management. As such, the authors go on to assess the impact of the addition of montelukast to ongoing asthma treatment in terms of improvement in clinical parameters, symptom control and quality of life. The closing chapter focuses on leukotrienes, formed by leukocytes, which are inflammatory mediators that play an active role in early and late-phase immune response. This group includes montelukast, zafirlukast and prankulast.

Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide

Автор: N. Allon; S. Shapira; B.A. Weissman
Название: Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide
ISBN: 1461357772 ISBN-13(EAN): 9781461357773
Издательство: Springer
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Цена: 104480.00 T
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Описание: A decade ago, for most scientists investigating various issues in life sciences the word "NO" was used in a negative context. NO is implicated in long-term potentiation (LPT), a principal process involved in memory consolidation and it is considered as the main biochemical substance responsible for penile erection.

Pharmacological Control of Lipid Metabolism

Автор: W. Holmes
Название: Pharmacological Control of Lipid Metabolism
ISBN: 1468475495 ISBN-13(EAN): 9781468475494
Издательство: Springer
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Цена: 46570.00 T
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Описание: Each meeting has introduced or developed some new concepts in the areas of lipid metabolism and drugs. Principal among the many new concepts discussed were lipoprotein synthesis and metabolism, apoprotein structure and function, whole body metabolism of cholesterol, and aspects of myocardial and aortic metabolism.

Pharmacological Intervention in the Aging Process

Автор: Jay Roberts
Название: Pharmacological Intervention in the Aging Process
ISBN: 1468477951 ISBN-13(EAN): 9781468477955
Издательство: Springer
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Цена: 46570.00 T
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Описание: In the nearly three years that have elapsed since our first Philadelphia Symposium on Aging, our activities and interactions have expanded. For the first symposium, a variety of topics relating to the study of aging, ranging from phenomena at the cellular level to phenomena in disease states, were selected for consideration.


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