This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Laurence Brunton, Bruce Chabner Название: Goodman And Gilman`s Pharmacological Basis Of Therapeutics 12 ed ISBN: 0071624422 ISBN-13(EAN): 9780071624428 Издательство: McGraw-Hill Рейтинг: Цена: 116690.00 T Наличие на складе: Есть Описание: A medical text that represents accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. It helps thousands of practitioners and students to an understanding of the drugs essential to preventing, diagnosing, and treating disease.
Автор: Brunton, Laurence; Knollmann, Bjorn; Hilal-Dandan, Randa Название: Goodman and Gilman`s The Pharmacological Basis of Therapeutics, 13th Edition ISBN: 1259584739 ISBN-13(EAN): 9781259584732 Издательство: McGraw-Hill Рейтинг: Цена: 0.00 T Наличие на складе: Невозможна поставка. Описание: The gold-standard of pharmacology texts - updated to reflect the latest developments and breakthroughs
Автор: Amor Harland Название: The Pharmacological Guide to Haloperidol ISBN: 1536147001 ISBN-13(EAN): 9781536147001 Издательство: Nova Science Рейтинг: Цена: 103480.00 T Наличие на складе: Невозможна поставка. Описание: Haloperidol is the most common neuroleptic drugs associated with a range of side effects caused by interactions with other drugs. In The Pharmacological Guide to Haloperidol, the authors review cases that report common pharmacodynamic and pharmacokinetic drug interactions of haloperidol in vivo. Next, this compilation investigates methods for the determination of haloperidol in body fluids such as blood, urine and cerebral spinal fluid. Several techniques discussed include magnetic resonance spectroscopy, spectrophotometry and high performance liquid chromatography. Also included is a description of haloperidol derivatives and their applications as antimicrobial agents, vasodilators and calcium channel blockers. Additionally, haloperidol derivatives that have potential applications for improving cardiac function and reducing oxidative stress are also addressed. The authors present some studies which use functional magnetic resonance imaging to study aspects of haloperidol on facial expressions. Emotion processing is often notable in neurodegenerative diseases such as schizophrenia and evaluated in cerebral blood flow response in diseased patients. The following chapter focuses on a literature analysis of the use of haloperidol, with studies indicating a potential limit for haloperidol efficacy; values above this limit dont appear to provid any supplementary clinical improvement. Lastly, the authors provide a review of studies that have used magnetic resonance imaging to monitor haloperidol in vivo. Applications of 1H and 19F MRI in drug monitoring are discussed and a list of relevant studies is presented.
Автор: T. Godfraind; G. Mancia; M.P. Abbracchio; L. Aguil Название: Pharmacological Control of Calcium and Potassium Homeostasis ISBN: 9401040567 ISBN-13(EAN): 9789401040563 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. Calcium homeostasis within the cell is not only regulated by calcium channels;
Автор: Jay Roberts Название: Pharmacological Intervention in the Aging Process ISBN: 1468477951 ISBN-13(EAN): 9781468477955 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In the nearly three years that have elapsed since our first Philadelphia Symposium on Aging, our activities and interactions have expanded. For the first symposium, a variety of topics relating to the study of aging, ranging from phenomena at the cellular level to phenomena in disease states, were selected for consideration.
Автор: W. Holmes Название: Pharmacological Control of Lipid Metabolism ISBN: 1468475495 ISBN-13(EAN): 9781468475494 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Each meeting has introduced or developed some new concepts in the areas of lipid metabolism and drugs. Principal among the many new concepts discussed were lipoprotein synthesis and metabolism, apoprotein structure and function, whole body metabolism of cholesterol, and aspects of myocardial and aortic metabolism.
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