Attractors and Higher Dimensions in Population and Molecular Biology: Emerging Research and Opportunities, Gennadiy Vladimirovich Zhizhin

Автор: Walsh
Название: Antibiotics: Challenges, Mechanisms, Opportunities
ISBN: 1555819303 ISBN-13(EAN): 9781555819309
Издательство: Wiley
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Цена: 109770.00 T
Наличие на складе: Поставка под заказ.
Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:  • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed?  Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.

Автор: Manuel Ruiz-Garcia, Joseph M Shostell
Название: Molecular Population Genetics, Evolutionary Biology & Biological Conservation of Neotropical Carnivores
ISBN: 1624170714 ISBN-13(EAN): 9781624170713
Издательство: Nova Science
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Цена: 350580.00 T
Наличие на складе: Невозможна поставка.
Описание: System science and engineering is a field that covers a wide spectrum of modern technology. A system can be seen as a collection of entities and their interrelationships, which forms a whole greater than the sum of the entities and interacts with people, organizations, cultures and activities and the interrelationships among them. Systems composed of autonomous subsystems are not new, but the increased complexity of modern technology demands ever more reliable, intelligent, robust and adaptable systems to meet evolving needs. This book presents papers delivered at the International Conference on System Science and Engineering ICSSE2015,

Автор: Cutter, Asher D. (professor, Professor, Department Of Ecology & Evolutionary Biology, University Of Toronto, Canada)
Название: Primer of molecular population genetics
ISBN: 0198838948 ISBN-13(EAN): 9780198838944
Издательство: Oxford Academ
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Цена: 105600.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides a concise, accessible introduction to the principle ideas, methods, and caveats for understanding evolution at the molecular level.