Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity.
In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "dynamic duo", offering a most effective neuroprotective treatment option to patients.
Автор: Michael R. Hamblin, Cleber Ferraresi, Ying-Ying Huang, Lucas Freitas de Freitas, James D. Carroll Название: Low-Level Light Therapy: Photobiomodulation ISBN: 151061415X ISBN-13(EAN): 9781510614154 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 57690.00 T Наличие на складе: Невозможна поставка. Описание: Low-level light therapy (or photobiomodulation therapy) is a rapidly growing approach to treating a wide range of diseases and disorders that afflict humanity. This Tutorial Text covers the basic molecular and cellular mechanisms of action, applications for treating diseases in animal models, and its use in clinical trials and therapeutic practice in patients. Other topics include the two basic chromophores and how they trigger the signaling pathways, activation of transcription factors, and mobilization of stem cells; how the light-source design and the relevant energy parameters can affect the outcome of therapy; and the physics and tissue-optics principles that concern LLLT.
Автор: Hamblin, Michael R. Название: Photobiomodulation In The Brain ISBN: 0128153059 ISBN-13(EAN): 9780128153055 Издательство: Elsevier Science Рейтинг: Цена: 153830.00 T Наличие на складе: Невозможна поставка. Описание:
Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience presents the fundamentals of photobiomodulation and the diversity of applications in which light can be implemented in the brain. It will serve as a reference for future research in the area, providing the basic foundations readers need to understand photobiomodulation's science-based evidence, practical applications and related adaptations to specific therapeutic interventions. The book covers the mechanisms of action of photobiomodulation to the brain, and includes chapters describing the pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders, including traumatic events, degenerative diseases and psychiatric disorders.
Provides a much-needed reference on photobiomodulation with an unprecedented focus on the brain and its disorders
Features a body of world-renowned editors and chapter authors that promote research, policy and funding
Discusses the recent and rapid accumulation of literature in this area of research and the shift towards the use of non-invasive techniques in therapy
Автор: Heidi Abrahamse, Michael R. Hamblin Название: Photomedicine and Stem Cells: The Janus Face of Photodynamic Therapy (PDT) to Kill Cancer Stem Cells, and Photobiomodulation (PBM) to Stimulate Normal Stem Cells ISBN: 1681743205 ISBN-13(EAN): 9781681743202 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 61910.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Janus, the ancient Roman god depicted with two faces is an appropriate metaphor for light therapy. In the right photodynamic therapy conditions, light is able to kill nearly anything that is living. On the opposite face, light of the correct wavelength and proper dose can heal, regenerate, protect, revitalize and restore. This book discusses both sides of Janus` face in regards to light therapy.
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