Автор: Randall J. Mrsny, Ann Daugherty Название: Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes ISBN: 1420078062 ISBN-13(EAN): 9781420078060 Издательство: Taylor&Francis Рейтинг: Цена: 128620.00 T Наличие на складе: Есть Описание: Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.
Key features include:
issues related to delivery of protein and peptide therapeutics in elderly populations and pharmacogenomics
lessons learned on the major marketed areas of proteins and peptides, including interleukins, interferons, growth factors, and peptide hormones
innovations for protein and peptide delivery such as needle-less delivery
strategies for delivery of these molecules to locations such as the eye and brain
generic issues of proteins and peptides
Автор: Ryadnov Название: Amino Acids, Peptides and Proteins: Volume 41 ISBN: 1782625372 ISBN-13(EAN): 9781782625377 Издательство: Royal Society of Chemistry Рейтинг: Цена: 443450.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Amino Acids, Peptides and Proteins comprises a comprehensive and critical review of significant developments at the biology and chemistry interface. Compiled by leading researchers in their subject, this volume incorporates current trends and emerging areas for example discovery and validation of novel protein/peptide biomarkers, proteins and peptides for the diagnosis and therapy of a parasite infection and surface and interface analysis of functional proteins and peptides. Appealing broadly to researchers in academia and industry, it will be of great benefit to any researcher wanting a succinct reference to developments now and looking to the future.
Автор: ?lo Langel Название: CPP, Cell-Penetrating Peptides ISBN: 981138746X ISBN-13(EAN): 9789811387463 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Нет в наличии. Описание: In this book, a summary and update of the most important areas of CPP research are presented, whilst raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo are discussed. Therapeutic potential of CPPs and commercial developments are discussed. The monograph is written for researchers and students in the field.
Автор: C. M. Camargo, Beatriz L. Fernandes, Lilian Cruz Название: Bioactive Peptides Produced by Limited Proteolysis ISBN: 1615043683 ISBN-13(EAN): 9781615043682 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 41580.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proteins are considered supremely important for the organization, survival, and functioning of living organisms. They were considered stable and static molecules until the early 1940s, when Rudolph Schoenheimer demonstrated that proteins exist in a constant dynamic process of synthesis and degradation (proteostasis), absolutely essential for life. Since then, general and limited protein degradation became some of the most fascinating aspects of biological sciences. This book is focused on a particular aspect of protein degradation, namely, limited proteolysis, which gives rise to bioactive peptides as a result of the enzymatic action of proteinases and peptidases, which are enzymes that hydrolyze specific peptide bonds of proteins and peptides, respectively. In a broad sense, bioactive peptides are any fragment of endogenous or exogenous proteins able to elicit either physiological or pathological activities. Here, we aim at presenting to the readers that bioactive peptides are not merely produced through random processes during protein degradation, but rather through a well-organized enzymatic process that is deeply integrated in the homeostatic processes of living organisms.
Название: Bioactive Peptides ISBN: 0367385732 ISBN-13(EAN): 9780367385736 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Focuses on Biology, Pharmacology, and Therapeutic Applications
The study and diverse applications of bioactive peptides traverse many sub-disciplines within chemistry, biology, physics, and medicine. Answering a long-standing need, Bioactive Peptides focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. Moving peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics, it presents the overall contribution that peptide science has made to molecular, cellular, and whole organism biology, while also discussing future targets and therapeutic applications.
Beneficial for Experts and Novices Alike
Part I provides details of bioactive peptides that interact with common drug targets and analyzes some of the most competitive areas of current research worldwide. While it is widely known that mammalian physiological systems utilize bioactive peptides that have yet to be discovered, other animals provide a rich and valuable source of bioactive peptides. This fascinating area of science is the theme of Part II.Parts III and IV investigate the unique bioactivities of various peptides that are ripe for further exploration.
This definitive reference also includes:
A detailed description and analysis of a broad range of peptides that interact with G protein-coupled receptors, the quantitatively dominant drug target
A discussion of non-ribosomal peptides, which hold promise as sources of endogenous mediators
Important examples of common methodologies employed to identify, characterize, and further develop bioactive peptides from a range of natural sources
With mounting worldwide interest in their therapeutic potential, bioactive peptides-includ
Автор: Weiner, David B. Williams, William V. Название: Biologically active peptides ISBN: 0877629358 ISBN-13(EAN): 9780877629351 Издательство: Taylor&Francis Рейтинг: Цена: 224570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Investigation into basic and advanced peptide design, synthesis, evaluation and utilization
Автор: Terry W. Moody Название: Growth Factors, Peptides, and Receptors ISBN: 1461362326 ISBN-13(EAN): 9781461362326 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the XIIth Washington International Spring Symposium at George Washington University held in Washington, D.C., June 1-5, 1992
Автор: Susanne Holmgren Название: The Comparative Physiology of Regulatory Peptides ISBN: 9401068623 ISBN-13(EAN): 9789401068628 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Strictly speaking, the term regulatory peptides may include any peptide which has a regulatory function in any organism. The peptides initially defined as those belonging to the brain- gut axis had a dual location in neurones of the brain and endocrine cells of the gut.
Автор: Xiao-Jie Xu; Yun-Hua Ye; James P. Tam Название: Peptides ISBN: 9401741085 ISBN-13(EAN): 9789401741088 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the 1996 Chinese Peptide Symposium, Chengdu, China, 21-25 July 1996
Автор: Farkas Etelka Название: Amino Acids, Peptides and Proteins: Volume 38 ISBN: 1849735859 ISBN-13(EAN): 9781849735858 Издательство: Royal Society of Chemistry Рейтинг: Цена: 443450.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Amino Acids, Peptides and Proteins comprises a comprehensive review of significant developments at this biology/chemistry interface. Each volume of this Specialist Periodical Report opens with an overview of amino acids and their applications. In keeping with the preceeding volumes in the series, this volume presents contributions from across the globe addressing the hot topics in the field. Disulfide-containing peptides and proteins are investigated by NMR, and mass spectrometry is used to determine inter-peptide distant constraints. Further chapters review the latest literature on antimicrbial peptides, modifications by Cytochrome P450 and the relaxin-family neuropeptides. Self-assembly and the moleculatr recognition of designed peptides are also discussed, and the latest in peptide and protein-based pharmaceuticals are reviewed. Volume editor Max Ryadnov also contributes a chapter on biofunctional peptide design. As the published literature in the field continues to grow, researchers in academia and industry will find this comprehensive review of the current research and thought an essential first point of reference.
Название: High-Performance Liquid Chromatography of Peptides and Proteins ISBN: 0367402963 ISBN-13(EAN): 9780367402969 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book consists of a series of 82 precise, easy-to-read articles by internationally renowned scientists and emphasizes the practical approach to HPLC with minimal theory, although the underlying principles for peptide and protein separations are clearly expressed. All of the major modes of microbore, ultrafast and analytical HPLC are discussed, including size-exclusion, ion-exchange, reversed-phase, hydrophobic interaction, and affinity and immunoaffinity chromatography. A section on preparative HPLC, including displacement techniques, is also presented.
Автор: Andrew E. Nixon Название: Therapeutic Peptides ISBN: 1627036725 ISBN-13(EAN): 9781627036726 Издательство: Springer Рейтинг: Цена: 97820.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Therapeutic Peptides: Methods and Protocols features biological methods for the preparation of peptide phage display libraries using both filamentous and lytic phage.
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