Lipid-Activated Nuclear Receptors, Matthew C. Gage; In?s Pineda-Torra
Автор: Jihan A. Youssef; Mostafa Z. Badr Название: Peroxisome Proliferator-Activated Receptors ISBN: 1627034196 ISBN-13(EAN): 9781627034197 Издательство: Springer Рейтинг: Цена: 148020.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book reviews the history of PPAR discovery and details receptor structure and its posttranslational modifications, discusses endogenous and exogenous ligands, the tissue distribution and versatile functions of PPAR subtypes in major organs and much more.
Автор: Jihan A. Youssef; Mostafa Z. Badr Название: Peroxisome Proliferator-Activated Receptors ISBN: 1627038868 ISBN-13(EAN): 9781627038867 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book reviews the history of PPAR discovery and details receptor structure and its posttranslational modifications, discusses endogenous and exogenous ligands, the tissue distribution and versatile functions of PPAR subtypes in major organs and much more.
Автор: Mostafa Z. Badr; Jihan A. Youssef Название: Peroxisome Proliferator-Activated Receptors (PPARs) ISBN: 1493962574 ISBN-13(EAN): 9781493962570 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology but differ in function, tissue distribution and ligand specificity. PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, and efforts are currently underway to fully characterize their functioning and to develop safer and more effective PPAR modulators to treat a myriad of diseases and conditions. In Peroxisome proliferator-Activated Receptors: Methods and Protocols, renowned experts in the PPAR arena provide detailed protocols for investigating these receptors. Chapters contain methods ranging from the cloning of receptors to their knockdown, to protocols exploring posttranslational modifications of PPARs and coactivators, as well as receptor subcellular localization. Also assembled are methods to evaluate the involvement of these receptors in behavior functions, an emerging facet in PPAR research. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. With its well-honed methodologies, Peroxisome proliferator-Activated Receptors: Methods and Protocols, will be a useful resource for all seeking to advance their knowledge of this field.
Автор: Rodrigo B. Valenzuela Название: Peroxisome Profilerator-Activated Receptors (PPARs): Structure, Mechanisms of Action and Role in Health and Disease ISBN: 1536147370 ISBN-13(EAN): 9781536147377 Издательство: Nova Science Рейтинг: Цена: 215410.00 T Наличие на складе: Невозможна поставка. Описание: Worldwide, the prevalence of chronic diseases, such as obesity, diabetes, cardiovascular diseases, cancer, non-alcoholic fatty liver disease, inflammatory (autoimmune) and neurodegenerative diseases, has shown a sharp increase. In the last 20 years, developing countries and the young population have presented the largest augment in the incidence of these diseases, which evidences that they are not only limited to developed countries nor the adult population. These pathologies have in common a complex interaction between genetic, metabolic and environmental factors. In this context, several basic and clinical researches have demonstrated the relevance of the expression and activity of the peroxisomal proliferator-activated receptors (PPARs) as fundamental elements in the prevention and treatment of chronic diseases. PPARs are a family of transcription factors that control many cellular metabolic processes. PPAR isoform expression and activity is regulated in different tissues according to physiological processes (growth, development, and aging) and to pathological conditions (cardiovascular diseases, inflammatory diseases, neurodegenerative diseases, hepatic diseases, among others). Also, different compounds such as drugs (fibrates), nutrients (long-chain polyunsaturated fatty acids), and several natural bioactive compounds (polyphenols) are molecular regulators of PPARs expression and activity. Recent research has established the importance of the regulation of PPARs activity and their role in cell and tissue protection against injury (i.e., oxidative stress, inflammation, endoplasmic reticulum stress). This book is dedicated to reviewing the state of the art regarding PPARs regulation with an emphasis on molecular aspects underlying their effect in health and disease. Specifically, the participation of PPARs is discussed in insulin resistance, inflammation, NAFLD, DM2, cardiovascular disease, hypertension, obesity, gastrointestinal disease, and neurological health and disease. Moreover, this book reviews how different molecules regulate the expression and activity of PPARs. Finally, the scientific information presented in this book pretends to contribute to a greater understanding of PPAR role in the prevention and treatment of different pathologies and metabolic alterations.
Автор: J.-C. Fruchart; Antonio M. Gotto Jr.; Rodolfo Paol Название: Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications ISBN: 1461354277 ISBN-13(EAN): 9781461354277 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Peroxisome Proliferator Activated Receptors (PPARs) attract great attention in light of the wide spectrum of genes of biological and medical relevance identified as under their control.
Автор: J.-C. Fruchart; Antonio M. Gotto Jr.; Rodolfo Paol Название: Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications ISBN: 140207199X ISBN-13(EAN): 9781402071997 Издательство: Springer Рейтинг: Цена: 186340.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Peroxisome Proliferator Activated Receptors (PPARs) attract great attention in light of the wide spectrum of genes of biological and medical relevance identified as under their control. This volume provides a view of the clinical and scientific developments within this area of study.
Автор: Cooney, David O. Название: Activated Charcoal in Medical Applications ISBN: 0367401916 ISBN-13(EAN): 9780367401917 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Highlighting activated charcoal's great effectiveness in treating drug overdoses and poisonings in both humans and animals, this comprehensive, single-source reference brings together vital information from every significant study on the use of activated charcoal for medical purposes-describing all available charcoal products and their characteristics.
Details activated charcoal's ability to reduce the systemic absorption of a vast array of drugs, chemicals, and biochemical substances-including analgesics, antipyretics, sedatives, alkaloids, snake venoms, and bacterial and fungal toxins.
Автор: Robert J. Seviour; L. Blackall Название: The Microbiology of Activated Sludge ISBN: 9401057540 ISBN-13(EAN): 9789401057547 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book is not meant to compete directly with the books by Gray (1989, 1990) nor the excellent manual published by Jenkins and coworkers (1993b), which has been invaluable to us and others trying to identify filamentous bacteria.
Автор: Francesc Posas; Angel R. Nebreda Название: Stress-Activated Protein Kinases ISBN: 3642094805 ISBN-13(EAN): 9783642094804 Издательство: Springer Рейтинг: Цена: 269260.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals.
Автор: Mario D. Cordero; Benoit Viollet Название: AMP-activated Protein Kinase ISBN: 3319435876 ISBN-13(EAN): 9783319435879 Издательство: Springer Рейтинг: Цена: 204970.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease.
Автор: Francesc Posas; Angel R. Nebreda Название: Stress-Activated Protein Kinases ISBN: 3540755683 ISBN-13(EAN): 9783540755685 Издательство: Springer Рейтинг: Цена: 269260.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Stress stimuli result in the rapid activation of a highly conserved group of MAP kinases, known as SAPKs (Stress-Activated Protein Kinases). These kinases coordinate the generation of adaptive responses that are essential for cell survival. This book discusses many aspects of SAPK signalling in various systems from yeast to mammals.
