Innovations for Next-Generation Antibody-Drug Conjugates, Marc Damelin
Автор: Damelin Marc Название: Innovations for Next-Generation Antibody-Drug Conjugates ISBN: 3319781537 ISBN-13(EAN): 9783319781532 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
Автор: Ulf Grawunder; Stefan Barth Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins ISBN: 3319468758 ISBN-13(EAN): 9783319468754 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.
The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Автор: Ulf Grawunder; Stefan Barth Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins ISBN: 3319836099 ISBN-13(EAN): 9783319836096 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Автор: Gail Lewis Phillips Название: Antibody-Drug Conjugates and Immunotoxins ISBN: 1489997008 ISBN-13(EAN): 9781489997005 Издательство: Springer Рейтинг: Цена: 148010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume collets leading research on antibody-drug conjugates and immunotoxins. It examines all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.
Автор: Laurent Ducry Название: Antibody-Drug Conjugates ISBN: 1493960261 ISBN-13(EAN): 9781493960262 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.
Автор: Ducry Название: Antibody-Drug Conjugates ISBN: 1627035400 ISBN-13(EAN): 9781627035408 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.
Автор: Roland E. Kontermann; Stefan D?bel Название: Antibody Engineering Volume 2 ISBN: 3642011462 ISBN-13(EAN): 9783642011467 Издательство: Springer Рейтинг: Цена: 214280.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book is a toolbox of well-established basics and many exciting new techniques in antibody engineering, reflecting the latest hands-on work of key laboratories in this fast-moving field. The new edition is expanded to nearly double the number of protocols.
Автор: Roland E. Kontermann; Stefan D?bel Название: Antibody Engineering Volume 1 ISBN: 3642011438 ISBN-13(EAN): 9783642011436 Издательство: Springer Рейтинг: Цена: 279500.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book is a toolbox of well-established basics and many exciting new techniques in antibody engineering, reflecting the latest hands-on work of key laboratories in this fast-moving field. The new edition is expanded to nearly double the number of protocols.
Автор: Mohamed Al-Rubeai Название: Antibody Expression and Production ISBN: 9400736134 ISBN-13(EAN): 9789400736139 Издательство: Springer Рейтинг: Цена: 191550.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers generation, optimization, characterization, production and applications of antibodies, offering theoretical background and describing methods for expression of antibody in microbial and animal cell cultures and transgenic animals and plants.
Автор: Roland E. Kontermann; Stefan D?bel Название: Antibody Engineering Volume 2 ISBN: 3642422764 ISBN-13(EAN): 9783642422768 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
Автор: Kenneth A. Foon; Alton C. Morgan Название: Monoclonal Antibody Therapy of Human Cancer ISBN: 1461296420 ISBN-13(EAN): 9781461296423 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
