Drosophila Models for Human Diseases, Masamitsu Yamaguchi

Название: Current topics in human genetics: studies in complex diseases
ISBN: 9812704728 ISBN-13(EAN): 9789812704726
Издательство: World Scientific Publishing
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Описание: Application of genomic, proteomic, and bioinformatics technologies to study of human genetics has made it possible for human genetic diseases to be studied on an unprecedented scale. This work provides coverage of a range of research topics in this area. It reviews a spectrum of approaches to human genetics research.

Автор: Yamaguchi
Название: Drosophila Models for Human Diseases
ISBN: 9811305285 ISBN-13(EAN): 9789811305283
Издательство: Springer
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Описание: Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.

Автор: Seppo Lakovaara
Название: Advances in Genetics, Development, and Evolution of Drosophila
ISBN: 1461583233 ISBN-13(EAN): 9781461583233
Издательство: Springer
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Цена: 113190.00 T
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Описание: This article, 55 pages long and published in the Proceedings of the Amer- ican Academy, described experiments performed with Drosophila ampe- lophila Lov, "a small dipterous insect known under various popular names such as the little fruit fly, pomace fly, vinegar fly, wine fly, and pickled fruit fly."

Автор: Bin Chen
Название: Grauzone and Completion of Meiosis During Drosophila Oogenesis
ISBN: 1461355397 ISBN-13(EAN): 9781461355397
Издательство: Springer
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Описание: Grauzone and Completion of Meiosis During Drosophila Oogenesis describes the work behind a major, award winning discovery: the establishment of a new pathway that specifically regulates the female meiosis, a process essential for sexual reproduction.

Автор: Pierre Capy; Patricia Gibert; Ian Boussy
Название: Drosophila melanogaster, Drosophila simulans: So Similar, So Different
ISBN: 9401037558 ISBN-13(EAN): 9789401037556
Издательство: Springer
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Цена: 139750.00 T
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Описание: Comparison of closely related species is a powerful D. melanogaster. In D. melanogaster, microsatel- approach to understanding the changes that have oc- lites reveal that West African popUlations are more curred since their divergence from a common ancestor. closely related to non-African populations than to The sibling species Drosophila melanogaster and D. East African popUlations. East African populations are simulans are probably the species pair for which the more variable than West African or non-African popu- most genetic data are available. A workshop held at lations, suggesting that East African populations may 1 Gif/Yvette in January 2002 reviewed and discussed more closely reflect African ancestral variability. comparisons between these species, from their ecol- Ecophysiology, popUlation dynamics and popula- tion structure are also important to understanding the ogy and biogeography to their behavior and DNA evolution of the two species. Genetic diversity (8) polymorphism. is higher in D. simulans (S. Mousset and R. Singh).

Автор: Dahmann
Название: Drosophila
ISBN: 1493963694 ISBN-13(EAN): 9781493963690
Издательство: Springer
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Описание: This second edition volume expands on the previous edition by presenting updated protocols for several of the techniques described in the first edition of Drosophila: Methods and Protocols and current methods that cover recent breakthroughs in Drosophila research. The book begins with a description of FlyBase--a database of genes and genomes--followed by the presentation of systems for versatile gene expression in the fly. The first few chapters in this book detail gene knockdown and editing, including CRISPR-Cas9 and protein knockdown. The next few chapters are devoted to methods describing live imaging of different tissues and organs, followed by chapters on how to quantify image data and how to probe tissue mechanics by laser ablation. The next two chapters provide methods for analyzing transcription followed by protocols to study growth, metabolism, ageing, and behavior in Drosophila. This volume concludes with chapters on electrophysiological recordings and methods to establish cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Drosophila: Methods and Protocols, Second Edition is a valuable source of hands-on protocols and reviews for molecular, cell, and developmental biologists using Drosophila as model systems in their work.

Автор: J.S.F. Barker; William T. Starmer; Ross J. MacInty
Название: Ecological and Evolutionary Genetics of Drosophila
ISBN: 1468487701 ISBN-13(EAN): 9781468487701
Издательство: Springer
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Цена: 113190.00 T
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Описание: Proceedings of an international workshop held in Armidale, Australia, January 5-10, 1989

Автор: Amit Singh; Madhuri Kango-Singh
Название: Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye
ISBN: 1493953036 ISBN-13(EAN): 9781493953035
Издательство: Springer
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Цена: 139310.00 T
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Описание: This book will discuss molecular genetic mechanisms of pattern formation, mutations in axial patterning, Genetic regulation of growth in Drosophila eye, and more.

Автор: Abul K. Abbas; Richard A. Flavell
Название: Genetic Models of Immune and Inflammatory Diseases
ISBN: 1461275202 ISBN-13(EAN): 9781461275206
Издательство: Springer
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Описание: Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi cal response modifiers.

Автор: Nasheuer
Название: Genome Stability and Human Diseases
ISBN: 9048134706 ISBN-13(EAN): 9789048134700
Издательство: Springer
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Цена: 191560.00 T
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Описание: This comprehensive overview discusses cancer cell biology in relation to Genome stability and Cell cycle regulation. Chapters are devoted to genome stability and anti-cancer drug targets, chromatin factors, DNA repair, apoptosis and other key areas of research.

Автор: Gardner, Aaron Stauffer, Sarah Petley-ragan, Lindsay Wismer, Philip Ungu, Dewi Ayu Kencana
Название: Labster virtual lab experiments: genetics of human diseases
ISBN: 3662587432 ISBN-13(EAN): 9783662587430
Издательство: Springer
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Цена: 25540.00 T
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Описание: This textbook helps you to prepare for your next exams and practical courses by combining theory with virtual lab simulations. The "Labster Virtual Lab Experiments" series gives you a unique opportunity to apply your newly acquired knowledge in a learning game that simulates exciting laboratory experiments. Try out different techniques and work with machines that you otherwise wouldn't have access to.

In this book, you'll learn the fundamental concepts of the genetics of human diseases focusing on:

Monogenic Disorders - Cytogenetics - Medical Genetics - Viral Gene Therapy

In each chapter, you'll be introduced to one virtual lab simulation and a true-to-life challenge. Following a theory section, you'll be able to play the relevant simulation that includes quiz questions to reinforce your understanding of the covered topics. 3D animations will show you molecular processes not otherwise visible to the human eye.

If you have purchased a printed copy of this book, you get free access to five simulations for the duration of six months. If you're using the e-book version, you can sign up and buy access to the simulations at www.labster.com/springer.

If you like this book, try out other topics in this series, including "Basic Biology", "Basic Genetics", and "Basic Biochemistry".

Please note that the simulations included in the book are not virtual reality (VR) but 2D virtual experiments.

Автор: Nasheuer
Название: Genome Stability and Human Diseases
ISBN: 9400731256 ISBN-13(EAN): 9789400731257
Издательство: Springer
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Цена: 191550.00 T
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Описание: This comprehensive overview discusses cancer cell biology in relation to Genome stability and Cell cycle regulation. Chapters are devoted to genome stability and anti-cancer drug targets, chromatin factors, DNA repair, apoptosis and other key areas of research.