Personalized Therapy for Multiple Myeloma, Saad Z. Usmani; Ajay K. Nooka

Автор: Nikhil C. Munshi; Kenneth C. Anderson
Название: Advances in Biology and Therapy of Multiple Myeloma
ISBN: 1489989994 ISBN-13(EAN): 9781489989994
Издательство: Springer
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Цена: 174130.00 T
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Описание: Multiple myeloma remains incurable, immune to developments in cancer treatment such as high-dose chemotherapy and new kinds of agents. This volume assesses new approaches currently being developed that overcome drug resistance and improve patient outcomes.

Автор: Nikhil C. Munshi; Kenneth C. Anderson
Название: Advances in Biology and Therapy of Multiple Myeloma
ISBN: 1489989145 ISBN-13(EAN): 9781489989147
Издательство: Springer
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Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.

Автор: Morie A. Gertz; Philip R. Greipp
Название: Hematologic Malignancies: Multiple Myeloma and Related Plasma Cell Disorders
ISBN: 3642056431 ISBN-13(EAN): 9783642056437
Издательство: Springer
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Цена: 204040.00 T
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Описание: with contributions by numerous experts

Автор: Brown
Название: Multiple Myeloma
ISBN: 1617375373 ISBN-13(EAN): 9781617375378
Издательство: Springer
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Цена: 172350.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Offers a comprehensive collection of classic and innovative methodologies used in many laboratories for the investigation of multiple myeloma. This title offers readily reproducible techniques that range from the standard Plasma Cell Labeling Index methodology to a final chapter on making sense of microarrays.

Автор: Crowder Darell
Название: Advances in Multiple Myeloma
ISBN: 1632420341 ISBN-13(EAN): 9781632420343
Издательство: Неизвестно
Цена: 159860.00 T
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Автор: Christoph Heuck; Niels Weinhold
Название: Multiple Myeloma
ISBN: 1493993089 ISBN-13(EAN): 9781493993086
Издательство: Springer
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Цена: 102480.00 T
Наличие на складе: Нет в наличии.
Описание: This volume provides a thorough guide of the study of multiple myeloma (MM)—from sample acquisition to the performance of molecular tests, and also discusses difficulties that arise during quality control and interpretation of results. The chapters in this book cover topics, such as next-generation-flow-based methods for detection of minimal residual disease and circulating tumor cells; Cytometry by Time-of-Flights (CyTOF); a droplet digital PCR approach for finding contamination in patients’ samples; genome-wide investigation of the methylation and hydroxymethylation status of cytosines; and a microfluidic approach for creating nanoparticles. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Multiple Myeloma: Methods and Protocols is a valuable resource for molecular scientists and laboratory supervisors working with MM samples, and any investigator conducting studies in this field.

Автор: Crowder Darell
Название: Multiple Myeloma: An Updated Review
ISBN: 1632422794 ISBN-13(EAN): 9781632422798
Издательство: Неизвестно
Цена: 133030.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.