Systems Pharmacology and Pharmacodynamics, Donald E. Mager; Holly H.C. Kimko
Автор: Randall J. Mrsny, Ann Daugherty Название: Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes ISBN: 1420078062 ISBN-13(EAN): 9781420078060 Издательство: Taylor&Francis Рейтинг: Цена: 128620.00 T Наличие на складе: Есть Описание: Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.
Key features include:
issues related to delivery of protein and peptide therapeutics in elderly populations and pharmacogenomics
lessons learned on the major marketed areas of proteins and peptides, including interleukins, interferons, growth factors, and peptide hormones
innovations for protein and peptide delivery such as needle-less delivery
strategies for delivery of these molecules to locations such as the eye and brain
generic issues of proteins and peptides
Автор: Mager Название: Systems Pharmacology and Pharmacodynamics ISBN: 3319445324 ISBN-13(EAN): 9783319445328 Издательство: Springer Рейтинг: Цена: 204970.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
Автор: Younggil Kwon Название: Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists ISBN: 147578693X ISBN-13(EAN): 9781475786934 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization.
Автор: David D`Argenio Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis ISBN: 1475790236 ISBN-13(EAN): 9781475790238 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the 1990 Biomedical Simulations Resource Workshop, held in Marina del Rey, California, May 18-19, 1990
Автор: Kimko Hui Название: Simulation For Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective ISBN: 0824708628 ISBN-13(EAN): 9780824708627 Издательство: Taylor&Francis Рейтинг: Цена: 183750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to design clinical trials according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.
Автор: Andrew A. Udy; Jason A. Roberts; Jeffrey Lipman Название: Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill ISBN: 9811053359 ISBN-13(EAN): 9789811053351 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill.
Автор: Udy Название: Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill ISBN: 9811353697 ISBN-13(EAN): 9789811353697 Издательство: Springer Рейтинг: Цена: 79190.00 T Наличие на складе: Поставка под заказ. Описание: This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill.
Название: Handbook of Pharmacokinetic/Pharmacodynamic Correlation ISBN: 0367228033 ISBN-13(EAN): 9780367228033 Издательство: Taylor&Francis Рейтинг: Цена: 153120.00 T Наличие на складе: Нет в наличии. Описание: This book provides a holistic representation of developments and patterns of mergers and acquisitions that have taken place in the Indian corporate sector especially in the post-liberalisation era. It also gives an overview of competitive strategies and performance of Indian industries under globalisation relating it with the specific characteristics of firms that engaged in overseas acquisitions.
Автор: Macheras Panos, Iliadis Athanassios Название: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics / Homogeneous and Heterogeneous Approaches ISBN: 0387281789 ISBN-13(EAN): 9780387281780 Издательство: Springer Рейтинг: Цена: 55850.00 T Наличие на складе: Поставка под заказ. Описание: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. www.springeronline.com
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