This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Cornel Mulhardt Название: Molecular Biology and Genomics, ISBN: 0120885468 ISBN-13(EAN): 9780120885466 Издательство: Elsevier Science Рейтинг: Цена: 45150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Never before has it been so critical for lab workers to possess the proper tools and methodologies necessary to determine the structure, function, and expression of the corresponding proteins encoded in the genome. Mulhardt's Molecular Biology and Genomics helps aid in this daunting task by providing the reader with tips and tricks for more successful lab experiments. This strategic lab guide explores the current methodological variety of molecular biology and genomics in a simple manner, addressing the assets and drawbacks as well as critical points. It also provides short and precise summaries of routine procedures as well as listings of the advantages and disadvantages of alternative methods.
Автор: T. Brown Название: Genomes 4 ISBN: 0815345089 ISBN-13(EAN): 9780815345084 Издательство: Taylor&Francis Рейтинг: Цена: 64300.00 T Наличие на складе: Нет в наличии. Описание:
Genomes 4 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with Genomes 3, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals including humans and other hominids.
Genome sequencing and assembly methods have been thoroughly revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the three chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic, concentrating on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are applications of transcriptome analysis, metabolomics, and systems biology. The final chapter is on genome evolution, focusing on the evolution of the epigenome, using genomics to study human evolution, and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important.
Each chapter has a set of short-answer questions, in-depth problems, and annotated further reading. There is also an extensive glossary. Genomes 4 is the ideal text for upper level courses focused on genomes and genomics.
Автор: Snyder Michael Название: Genomics and Personalized Medicine: What Everyone Needs to Know(r) ISBN: 0190234768 ISBN-13(EAN): 9780190234768 Издательство: Oxford Academ Рейтинг: Цена: 11610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.
Название: Genome-wide association studies and genomic prediction ISBN: 1627034463 ISBN-13(EAN): 9781627034463 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This Methods in Molecular Biology(TM) book covers phenotypes of interest as well as design issues for GWAS, methods for storing and handling large datasets, quality control measures, haplotype inference, and imputation and statistical approaches to data analysis.
Автор: Cedric Gondro; Julius van der Werf; Ben Hayes Название: Genome-Wide Association Studies and Genomic Prediction ISBN: 1493959646 ISBN-13(EAN): 9781493959648 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This Methods in Molecular Biology (TM) book covers phenotypes of interest as well as design issues for GWAS, methods for storing and handling large datasets, quality control measures, haplotype inference, and imputation and statistical approaches to data analysis.
Автор: Rolf Ohlsson Название: Genomic Imprinting ISBN: 3662219565 ISBN-13(EAN): 9783662219560 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The form and function of every living organism on the earth depends on the complex regulation of gene expression. This monograph focuses on a particular aspect of the epigenetic control of gene function: genomic imprinting.
Автор: Rex A. Dwyer Название: Genomic Perl ISBN: 052180177X ISBN-13(EAN): 9780521801775 Издательство: Cambridge Academ Цена: 49630.00 T Наличие на складе: Поставка под заказ. Описание: This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.
Автор: Khawaja Husnain Haider Название: Stem Cells: From Myth to Reality and Evolving ISBN: 3110642239 ISBN-13(EAN): 9783110642230 Издательство: Walter de Gruyter Цена: 123910.00 T Наличие на складе: Нет в наличии. Описание: This book is a continuum of the first two books published in the STEM CELLS series entitled "Stem Cells: From Drug to Drug Discovery" and "Stem Cells: From Hype to Real Hope" which were published in 2017 and 2019, respectively. The scope of the book encompasses a wide range of topics with a latitude from adult stem cells to pluripotent stem cells in regenerative medicine either alone or as part of the combinatorial therapeutic intervention approach as "drug" besides their application as tools (disease model) during drug development process. Written by a leading group of researchers, the book encompasses experimental to clinical aspects of stem/progenitors cells, their biology, and characteristics.
Автор: Isabelle Peter Название: Genomic Control Process ISBN: 0124047297 ISBN-13(EAN): 9780124047297 Издательство: Elsevier Science Рейтинг: Цена: 104410.00 T Наличие на складе: Поставка под заказ. Описание: Explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. This book covers a vast area of biological research to produce a genome oriented regulatory bioscience of animal life.
Автор: Wilkins Ralph G. Название: Animal Genetics for Chemists ISBN: 178262760X ISBN-13(EAN): 9781782627609 Издательство: Royal Society of Chemistry Рейтинг: Цена: 49270.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Setting out to cover the fundamentals of the subject, this book features humans, other mammals and occasionally other animals to illustrate principles.
Автор: Yongxian Wang, Zhenghua Wang Название: Proteomics and Biological Networks ISBN: 311046117X ISBN-13(EAN): 9783110461176 Издательство: Walter de Gruyter Цена: 148700.00 T Наличие на складе: Нет в наличии. Описание: This book presents molecular biology knowledge and mathematical theories of frequently-used algorithms in sequence comparison, gene finding, sequence evolution and structuring phylogenetic tree.
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