Biochemistry and Cell Biology of Ageing: Part I Biomedical Science, J. Robin Harris; Viktor I. Korolchuk

Автор: Aegerter Christof M.
Название: Introductory Physics for Biological Scientists
ISBN: 1108466508 ISBN-13(EAN): 9781108466509
Издательство: Cambridge Academ
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Цена: 66530.00 T
Наличие на складе: Поставка под заказ.
Описание: An introduction to the fundamental physical principles related to the study of biological phenomena. Chapters are structured around biological examples, and the topics covered include waves, optics and mechanics. With quiz questions and a detailed appendix, it is perfect for students looking to develop their quantitative and analytical tools.

Автор: Christof M. Aegerter
Название: Introductory Physics for Biological Scientists
ISBN: 1108423345 ISBN-13(EAN): 9781108423342
Издательство: Cambridge Academ
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Цена: 166850.00 T
Наличие на складе: Поставка под заказ.
Описание: An introduction to the fundamental physical principles related to the study of biological phenomena. Chapters are structured around biological examples, and the topics covered include waves, optics and mechanics. With quiz questions and a detailed appendix, it is perfect for students looking to develop their quantitative and analytical tools.

Автор: Michael Dean, Karobi Moitra
Название: Cancer: Blueprint of a Tumor
ISBN: 1615047964 ISBN-13(EAN): 9781615047963
Издательство: Mare Nostrum (Eurospan)
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Цена: 50120.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Scientists are deciphering the biology of the tumor cell at a level of detail that would have been hard to imagine just a decade or so ago. The development of high-throughput DNA sequencing and genomics technologies have allowed an understanding of the development, growth, survival, and spread of cancer cells in the body. From this information, we now have a basic blueprint or roadmap of how a single damaged cell can develop into a pre-malignant lesion, a primary tumor, and finally, a lethal tumor that may spread throughout the body and resist both medical therapy and host immune responses. In this book, we provide an overview of our current understanding of this cancer blueprint, which has been aided both by the study of familial cancer syndromes, in vitro studies of cancer cells, and animal models. Three classes of genes have emerged from these studies: tumor suppressor genes needed for normal growth control and DNA repair; oncogenes that regulate cell growth and survival, and epigenetic modifiers, enzymes that regulate the modification of DNA and the proteins that form chromatin. Each of these three classes of genes is mutated or altered at least once in virtually all malignant cancer cells. Current technologies permit the DNA sequencing of cancer exomes (coding gene sequencing), whole genomes, transcriptome (all expressed genes), and DNA methylation profiling. These studies show that all tumors have unique constellations of mutated, rearranged, amplified, and deleted genes. Single-cell sequencing further shows that there is extensive variation in individual cells in the tumor; that cancers evolve, and have many of the properties of a multi-cellular entity. Lastly, cancer cells, through mutations in epigenetic modifiers, can reprogram the genome and unlock entire developmental and gene expression pathways to adapt and survive in changing conditions. This reprogramming allows the tumor to elude the host body's defenses, radiotherapy, chemotherapy, and targeted therapy that we use in cancer treatment. Understanding this cancer blueprint paves the way for the development of future therapies to treat and eliminate cancer.

Автор: Michael Dean, Karobi Moitra
Название: Cancer: Blueprint of a Tumor
ISBN: 1615047948 ISBN-13(EAN): 9781615047949
Издательство: Mare Nostrum (Eurospan)
Рейтинг:
Цена: 33400.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Scientists are deciphering the biology of the tumor cell at a level of detail that would have been hard to imagine just a decade or so ago. The development of high-throughput DNA sequencing and genomics technologies have allowed an understanding of the development, growth, survival, and spread of cancer cells in the body. From this information, we now have a basic blueprint or roadmap of how a single damaged cell can develop into a pre-malignant lesion, a primary tumor, and finally, a lethal tumor that may spread throughout the body and resist both medical therapy and host immune responses. In this book, we provide an overview of our current understanding of this cancer blueprint, which has been aided both by the study of familial cancer syndromes, in vitro studies of cancer cells, and animal models. Three classes of genes have emerged from these studies: tumor suppressor genes needed for normal growth control and DNA repair; oncogenes that regulate cell growth and survival, and epigenetic modifiers, enzymes that regulate the modification of DNA and the proteins that form chromatin. Each of these three classes of genes is mutated or altered at least once in virtually all malignant cancer cells. Current technologies permit the DNA sequencing of cancer exomes (coding gene sequencing), whole genomes, transcriptome (all expressed genes), and DNA methylation profiling. These studies show that all tumors have unique constellations of mutated, rearranged, amplified, and deleted genes. Single-cell sequencing further shows that there is extensive variation in individual cells in the tumor; that cancers evolve, and have many of the properties of a multi-cellular entity. Lastly, cancer cells, through mutations in epigenetic modifiers, can reprogram the genome and unlock entire developmental and gene expression pathways to adapt and survive in changing conditions. This reprogramming allows the tumor to elude the host body's defenses, radiotherapy, chemotherapy, and targeted therapy that we use in cancer treatment. Understanding this cancer blueprint paves the way for the development of future therapies to treat and eliminate cancer.

Автор: Rafael Rubio, Maureen Knabb
Название: Endothelial Luminal Membrane-Glycocalyx: Functionalities in Health and Disease
ISBN: 1615047549 ISBN-13(EAN): 9781615047543
Издательство: Mare Nostrum (Eurospan)
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Цена: 58480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Focuses on the structural, biochemical, and diverse functional properties of the endothelial luminal membrane glycocalyx, an organelle which constitutes the endothelial cell "membrane". This volume provides the newcomer with a broad, basic, and brief perspective of the luminal endothelial vascular membrane, and for the more established investigator, a basic overview and integrated perspective.

Автор: Rafael Rubio, Maureen Knabb
Название: Endothelial Luminal Membrane-Glycocalyx: Functionalities in Health and Disease
ISBN: 1615047638 ISBN-13(EAN): 9781615047635
Издательство: Mare Nostrum (Eurospan)
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Цена: 83560.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Focuses on the structural, biochemical, and diverse functional properties of the endothelial luminal membrane glycocalyx, an organelle which constitutes the endothelial cell "membrane". This volume provides the newcomer with a broad, basic, and brief perspective of the luminal endothelial vascular membrane, and for the more established investigator, a basic overview and integrated perspective.

Автор: Sheetz, Michael (columbia University, New York) Yu, Hanry (national University Of Singapore)
Название: Cell as a machine
ISBN: 1107052734 ISBN-13(EAN): 9781107052734
Издательство: Cambridge Academ
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Цена: 74970.00 T
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Описание: Connecting underlying theory with real-world applications, this systematic and mathematically accessible textbook explains cell functions using the engineering principles of robust devices. It is ideal for undergraduate and graduate students taking single-semester courses in cell mechanics, biophysics and cell biology.

Автор: J. Robin Harris; Viktor I. Korolchuk
Название: Biochemistry and Cell Biology of Ageing: Part II Clinical Science
ISBN: 9811336806 ISBN-13(EAN): 9789811336805
Издательство: Springer
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Цена: 204970.00 T
Наличие на складе: Поставка под заказ.
Описание: This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Автор: MacLaren Donald
Название: Biochemistry for Sport and Exercise Metabolism
ISBN: 0470091851 ISBN-13(EAN): 9780470091852
Издательство: Wiley
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Цена: 44300.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: How do our muscles produce energy for exercise and what are the underlying biochemical principles involved? These are questions that students need to be able to answer when studying for a number of sport related degrees. This can prove to be a difficult task for those with a relatively limited scientific background.

Автор: Noble
Название: Dance to the Tune of Life
ISBN: 1107176247 ISBN-13(EAN): 9781107176249
Издательство: Cambridge Academ
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Цена: 24280.00 T
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Описание: Challenging the common gene-centric approach to organisms, this book articulates a relativistic theory of biology. It is grounded in up-to-date biological research and rigorous application of mathematics to biology; however, it is presented in a non-technical manner for the general reader, and requires no familiarity with complex biology, mathematics or philosophy.