Pathology, Prevention and Therapeutics of Neurodegenerative Disease, Singh
Автор: Kovacs Название: Neuropathology of Neurodegenerative Diseases Book and Online ISBN: 1107442427 ISBN-13(EAN): 9781107442429 Издательство: Cambridge Academ Рейтинг: Цена: 93990.00 T Наличие на складе: Поставка под заказ. Описание: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases. The book is packaged with a password, giving the user online access to all the text and images.
Автор: Yongxia Zhou Название: Multiparametric Imaging in Neurodegenerative Disease ISBN: 1536153389 ISBN-13(EAN): 9781536153385 Издательство: Nova Science Рейтинг: Цена: 149940.00 T Наличие на складе: Невозможна поставка. Описание: Neuroimaging techniques that can help elucidate and characterize the nature and mechanism of tissue injury and disease progression in neurodegenerative disease are of particular importance given its their roles in seeking successful preventive and therapeutic treatments. Studying large-scale samples with various disease mechanisms using multi-parametric imaging, as well as revealing the correlations between the neuroimaging metrics and clinical data including neurocognitive function and neuropsychological inventories to elucidate multiple factors affecting the neurodegeneration processes in brain are the main topics of this book. In addition, the neural underpins of cognitive and psychological functions with advanced functional imaging techniques can provide better cross-validation and clinical symptom relevance of multi-parametric data. Expanding the current findings with higher diagnosis accuracy and detection specificity in multiple neurodegenerative diseases as well as better differentiation of each type are the ultimate goal. The results in this book will extend the current notion of diagnosis value of various relatively new imaging techniques in multiple neurodegenerative diseases including traumatic brain injury, post-traumatic stress disorder, multiple sclerosis and early stage of Alzheimers disease such as mild cognitive impairment. Specifically, the neurobiology and related imaging findings of the four representative neurodegenerative diseases will be introduced and reviewed, including brain region-specific and disease-related alterations, unique clinical symptom of each disease, as well as previous findings and challenges. There is an increasing body of literature suggesting that damage to the default mode network, hypothalamus, thalamus and hippocampus neuronal networks and local injuries might be under-diagnosed and may account for some of the sequelae following the neurodegenerative injuries including trauma and dementia. The relatively novel imaging results to differentiate each disease using advanced functional connectivity, neuronal activity, microstructure integrity analysis based on structural connectivity, multi-dimensional morphometry and molecular imaging tracers including amyloid and tau for neuropathological burden quantification were presented to differentiate each type of disease. We then briefly reviewed some of the therapeutic effects of traditional Chinese medicine with neuroimaging quantifications to help treating neurodegenerative diseases. Finally, our work proves that the multi-parametric neuroimaging methods with more than twelve metrics and numerous tight clinical association data presented in this book are the most forefront and up-to-date with enough sensitivity, precision and resolution. Taken together, multiple neuroimaging metrics haved been demonstrated in this book to identify and quantify significant and distinct brain alterations at function, microstructure, morphology and molecular scales in different types of neurodegenerative diseases with high sensitivity and specificity. These comprehensive imaging features could be combined to improve disease diagnosis accuracy. The aim of this book is thus intended to provide both beginners and experts in biomedical imaging and health care a broad and complete picture as well as the new developments of using multiple metrics in improving disease identification and diagnosis accuracy. This book would hopefully capture the interests of colleagues interested in neurodegenerative disease diagnosis and treatment, and could help convey the methodological and integrative perspectives of multi-parametric neuroimaging applications.
Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease summarizes recent developments in intervention trials in neurodegenerative diseases, particularly Alzheimer's and Parkinson's, as well as increasing evidence for the overlap between drivers of metabolic and neurodegenerative disease that impact mitochondrial function and bioenergetics, and subsequently cellular function and pathophysiology. Topics covered include Brain Glucose and Ketone Utilization in Brain Ageing and Neurodegenerative Diseases; the Mitochondrial Hypothesis: Dysfunction, Bioenergetic Defects, and the Metabolic Link to Alzheimer's Disease; the Metabolic Impact on Neuroinflammation and Microglial Modulation in Neurodegenerative Diseases, the Impact of Circadian and Diurnal Rhythms on Cellular Metabolic Function and Neurodegenerative Diseases, and much more.
Summarizes the current status of and future research in Alzheimer's and Parkinson's diseases
Reviews the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases.
Автор: Baekelandt, Veerle Название: Disease-Modifying Targets in Neurodegenerative Disorders ISBN: 0128051205 ISBN-13(EAN): 9780128051207 Издательство: Elsevier Science Рейтинг: Цена: 78040.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.
This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.
Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress
Summarizes how patients are treated today, providing a glance at future disease management
Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists
Written and peer reviewed by outstanding scientists in their respective fields
Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer's and Parkinson's, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain - A Role in Type 2 Diabetes Mellitus and Alzheimer's disease; and much more.
Название: Glia & inflammation in neurodegenerative disease ISBN: 1594549842 ISBN-13(EAN): 9781594549847 Издательство: Nova Science Рейтинг: Цена: 155220.00 T Наличие на складе: Невозможна поставка. Описание: Reviews the knowledge with regard to immune responses and cell-cell interactions as they pertain to a variety of neurodegenerative diseases. This book considers the changing role of inflammation with development. It also presents a summary of the various therapeutic strategies employed both in the laboratory and at the clinical level.
Автор: Michael J. Hurley Название: Omic Studies of Neurodegenerative Disease - Part B,122 ISBN: 0128047623 ISBN-13(EAN): 9780128047620 Издательство: Elsevier Science Рейтинг: Цена: 162820.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Omic Studies of Neurodegenerative Disease: Part B is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields.
The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research.
Автор: Richard I. Morimoto; Yves Christen Название: Protein Quality Control in Neurodegenerative Diseases ISBN: 3642447066 ISBN-13(EAN): 9783642447068 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer`s disease, Parkinson`s disease, amyotrophic lateral sclerosis, Huntington`s disease, and other diseases of protein conformation.
Автор: Dennis J. Selkoe Название: Immunization Against Alzheimer`s Disease and Other Neurodegenerative Disorders ISBN: 3642639372 ISBN-13(EAN): 9783642639371 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Promising effects in mice of immunization by ss-amyloid stimulated substantial research efforts and high hopes.
Автор: Theresa Natalie Название: Encyclopedia of Neurodegenerative Diseases: Volume I (Disease Mechanisms) ISBN: 1632411768 ISBN-13(EAN): 9781632411761 Издательство: Неизвестно Цена: 156590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The mechanisms of neurodegenerative diseases are elucidated in this book. It throws light on the pathophysiological complexities of the mechanisms and factors that are most probably involved in a number of neurodegenerative and neuroinflammatory diseases
Автор: , Deol Parneet Kaur, Sandhu Simarjot Kaur Название: Probiotic Research in Therapeutics: Volume 4: Probiotics in Neurodegenerative Disorders ISBN: 9811667594 ISBN-13(EAN): 9789811667596 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Humans have numerous microorganisms residing in the body, especially in the gut, far exceeding the human body's normal mammalian cells. Recent research links the gut microbiome, the population of microorganisms living in the gastrointestinal tract, with brain diseases. This volume explores the concept and possibility of its extension to manage a galaxy of CNS diseases, including Parkinson's, Alzheimer's, Autism spectrum disorders, depression, insomnia, and chronic fatigue syndrome. This volume elaborates about communication channels between gut and brain via the vagus nerve, short-chain fatty acids including omega acids, and other inflammasomes. In contrast to the available books on the topic, this title is more versatile and endeavors to bring together scientific pre-clinical, and clinical claims on the probable psychobiotic implication of probiotic therapy. The book will appeal similar to the general public, students, experienced researchers, and academicians. It is endeavored to address an aspect of probiotic usage beyond gut disorders. We hope that it would be helpful to people studying the human nervous system and related conditions with their treatments.
Автор: Theresa Natalie Название: Encyclopedia of Neurodegenerative Diseases: Volume IV (Prevention and Management) ISBN: 1632411792 ISBN-13(EAN): 9781632411792 Издательство: Неизвестно Цена: 141010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Information regarding neurodegenerative diseases has been provided in this all-inclusive book. It concentrates on prevention as well as monitoring of the disease growth. Although the main etiology for distinct neurodegenerative diseases is not same, there
Казахстан, 010000 г. Астана, проспект Туран 43/5, НП2 (офис 2) ТОО "Логобук" Тел:+7 707 857-29-98 ,+7(7172) 65-23-70 www.logobook.kz
