Targeted learning in data science, Van Der Laan, Mark J. Rose, Sherri
Автор: Mark J. van der Laan; Sherri Rose Название: Targeted Learning in Data Science ISBN: 3319653032 ISBN-13(EAN): 9783319653037 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This textbook for graduate students in statistics, data science, and public health deals with the practical challenges that come with big, complex, and dynamic data.
Автор: Takashi Yamamoto Название: Targeted Genome Editing Using Site-Specific Nucleases ISBN: 4431562354 ISBN-13(EAN): 9784431562351 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Нет в наличии. Описание: This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.
Автор: Gao, Huile Название: Brain Targeted Drug Delivery Systems ISBN: 0128140011 ISBN-13(EAN): 9780128140017 Издательство: Elsevier Science Рейтинг: Цена: 151590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain.
Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers
Discusses key points in developing brain targeting drug delivery systems
Summarizes and presents currently available strategies for brain targeting drug delivery
Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research
Автор: Little Название: Statistical Analysis with Missing Data, Third Edit ion ISBN: 0470526793 ISBN-13(EAN): 9780470526798 Издательство: Wiley Рейтинг: Цена: 84430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Reflecting new application topics, Statistical Analysis with Missing Data offers a thoroughly up-to-date, reorganized survey of current methodology for handling missing data problems. The third edition reviews historical approaches to the subject and describe rigorous yet simple methods for multivariate analysis with missing values.
Автор: Rachael W. Sirianni; Bahareh Behkam Название: Targeted Drug Delivery ISBN: 1493993577 ISBN-13(EAN): 9781493993574 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Нет в наличии. Описание:
This volume looks at the latest techniques used to enable therapeutic molecules to be targeted for site-specific delivery. The chapters in this book discuss topics such as approaches to express biologically derived and synthetic nanocarriers; strategies to assist in nanocarrier targeting to specific cells and tissues; and methods for evaluating delivery and efficiency for new classes of agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and comprehensive, Targeted Drug Delivery: Methods and Protocols is a valuable resource for anyone interested in understanding the diversity of methods used in this evolving field.
Автор: Amanda Tivnan Название: Resistance to Targeted Therapies Against Adult Brain Cancers ISBN: 331946504X ISBN-13(EAN): 9783319465043 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.
Автор: Wheelan Charles Название: Naked Statistics: Stripping the Dread from the Data ISBN: 039334777X ISBN-13(EAN): 9780393347777 Издательство: Wiley Рейтинг: Цена: 14770.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A New York Times bestseller "Brilliant, funny...the best math teacher you never had." -San Francisco Chronicle
Автор: Mark J. van der Laan; Sherri Rose Название: Targeted Learning ISBN: 1461429110 ISBN-13(EAN): 9781461429111 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: As the size of data sets grows ever larger, the need for valid statistical tools is greater than ever. This book introduces super learning and the targeted maximum likelihood estimator, and discusses complex data structures and related applied topics.
This book is the first of its kind to offer a comprehensive and up-to-date discussion of the use of nanoscale materials for biomedical applications, with a particular focus on drug delivery, theragnosis and tissue regeneration. It also describes in detail the methods used in the preparation of nanoparticles. Response of nanoparticles in biological systems are also explored.
Nanotechnology has led to the advent of a new field, nanomedicine, which focuses on the use of nanomaterials as drug-delivery vehicles to develop highly selective and effective drugs. The combination of molecular imaging and nanotechnology has produced theragnostic nanoparticles, which allow the simultaneous detection and monitoring of diseases. Nanotechnology can also be combined with biomaterials to create scaffolds for tissue regeneration. Further, significant advances have been made in the areas of drug delivery, theragnostic nanoparticles and tissue regeneration materials. Some nanomedicines and tissue regeneration materials are already commercially available, while others are undergoing clinical trials, and promising results have been documented.
Despite the rapid advances in nanomedicine, there is a relative dearth of literature on the biomedical applications of nanoscale materials.
Автор: Uche Chude-Okonkwo; Reza Malekian; BT Maharaj Название: Advanced Targeted Nanomedicine ISBN: 3030110028 ISBN-13(EAN): 9783030110024 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents medical challenges as communication engineering problems. It offers the reader the interesting perspective of exploring and understanding disease pathology from the point of view of communication engineers. Therefore, diseases and their treatments can be addressed using conventional communication paradigms, approaches, tools and devices; thereby ushering in the interdisciplinary research platform termed advanced targeted nanomedicine. The rudimentary framework for advanced targeted nanomedicine is presented and expatiated across the seven chapters of this book.
Автор: Holmes Susan Название: Modern Statistics for Modern Biology ISBN: 1108705294 ISBN-13(EAN): 9781108705295 Издательство: Cambridge Academ Рейтинг: Цена: 54910.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Designed for a new generation of biologists, this textbook teaches modern computational statistics by using R/Bioconductor to analyze experimental data from high-throughput technologies. The presentation minimizes mathematical notation and emphasizes inductive understanding from well-chosen examples, hands-on simulation, and visualization.
Автор: Kristin Briney Название: Data Management for Researchers: Organize, maintain and share your data for research success ISBN: 1784270113 ISBN-13(EAN): 9781784270117 Издательство: NBN International Рейтинг: Цена: 42240.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Learning how to manage, share and preserve data is essential for active researchers. A comprehensive guide for scientific researchers providing everything they need to know about data management and how to organize, document, use and reuse their data.
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