A Prescription for Change: The Looming Crisis in Drug Development, Michael S. Kinch
Автор: Michael Kinch Название: A Prescription for Change: The Looming Crisis in Drug Development ISBN: 1469647575 ISBN-13(EAN): 9781469647579 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 31350.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes--and indeed because of them--our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy.
To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come.
Автор: Laszlo Endrenyi and Dr. Paul Declerck Название: Biosimilar Drug Product Development ISBN: 1498718795 ISBN-13(EAN): 9781498718790 Издательство: Taylor&Francis Рейтинг: Цена: 183750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult. Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.
Автор: Wang Jinmin Название: Institutional Change and the Development of Industrial Clust ISBN: 9814289043 ISBN-13(EAN): 9789814289047 Издательство: World Scientific Publishing Рейтинг: Цена: 85530.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Uses the New Institutional Economics Approach (NIE) to examine the formation and development of industrial clusters in China through multiple case studies of textile and clothing clusters in the Zhejiang province. This work illustrates the interaction between institutional change and the industrial development of China in transition.
Автор: Richert Lucas Название: Conservatism, Consumer Choice, and the Food and Drug Administration During the Reagan Era: A Prescription for Scandal ISBN: 0739182587 ISBN-13(EAN): 9780739182581 Издательство: Неизвестно Рейтинг: Цена: 203850.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Fully updated for Windows Server 2012 R2! Designed to help enterprise administrators develop real-world, job-role-specific skills - this Training Guide focuses on core infrastructure administration for Windows Server 2012 R2. Build hands-on expertise through a series of lessons, exercises, and suggested practices - and help maximize your performance on the job.
Автор: Gloria R Pattinson Название: Medicares Prescription Drug Program: Competition Issues & Cost Trends ISBN: 1634631226 ISBN-13(EAN): 9781634631228 Издательство: Nova Science Рейтинг: Цена: 173170.00 T Наличие на складе: Невозможна поставка. Описание: So much of great literature centres on explorations of gender, sex, and sexuality. What does it mean to be a proper man or woman; what if one cannot be properly called either? Should one wield one`s sexual power politically? What is the relation between law, divine or secular, and sexuality? What does it mean to fail at doing gender? These are just some of the questions that this volume examines.
Автор: Kenakin, Terry Название: Pharmacology in Drug Discovery and Development ISBN: 0128037520 ISBN-13(EAN): 9780128037522 Издательство: Elsevier Science Рейтинг: Цена: 74100.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development.
Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization.
This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery.
Автор: Decker, Michael Название: Design of Hybrid Molecules for Drug Development ISBN: 0081010117 ISBN-13(EAN): 9780081010112 Издательство: Elsevier Science Рейтинг: Цена: 162820.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed.
Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria.
With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.
Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes
Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied
Compares the advantages and disadvantages of these compounds
Includes the very latest developments, such as photoactivatable and photo-responsive drugs
Автор: Evens Название: Drug and Biological Development ISBN: 0387329781 ISBN-13(EAN): 9780387329789 Издательство: Springer Рейтинг: Цена: 85670.00 T Наличие на складе: Поставка под заказ. Описание: The book is a complete discussion of product development in the pharmaceutical and biotechnology industries from discovery, to product launch, and through life cycle management. Format is optimized for education and training of health care professionals, especially fellows in training (MD, PharmD, PhD), at universities. Format of the book is a set of figures, tables and lists, that can become power-point style slides as well, and the detailed narrative descriptions, including real-life examples, illustrations, controversies in industry, and references. Industry and research experts (multidisciplinary – MD, PharmD, and PhD) are editors and authors. An added CD-ROM (slides only) enhances utility and marketability of book to course directors, providing the highly sought after slides for lectures.
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