Clinical Research Monitoring: A European Approach, Van Dooren A A
Автор: Yitzhak Rosen Название: Drug Delivery: An Integrated Clinical and Engineering Approach ISBN: 1466565942 ISBN-13(EAN): 9781466565944 Издательство: Taylor&Francis Рейтинг: Цена: 148010.00 T Наличие на складе: Невозможна поставка. Описание: The book integrates clinical and engineering aspects of drug delivery. It discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, and simulations, and describes the latest drug delivery advances involving nanotechnology, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound.
Автор: Andrea Angelini Название: Voriconazole: Pharmacokinetics, Role in Therapeutic Drug Monitoring & Clinical Outcomes ISBN: 163463313X ISBN-13(EAN): 9781634633130 Издательство: Nova Science Рейтинг: Цена: 224920.00 T Наличие на складе: Невозможна поставка. Описание: In the last twenty years, the incidence of invasive fungal infections (IFI) has risen dramatically due to the prolongation of survival of patients with multiple risk factors for fungal infections and due to the increase of infection associated with travel. Moreover IFI in infants admitted to the neonatal intensive care unit are common and often fatal. Amphotericin B was for more than 40 years the gold standard for almost all IFI, but toxicity and resistance, especially of new and emerging pathogens remained important issues. Fluconazole and itraconazole have also the same disadvantage of resistance. After a long period of relative inactivity in the introduction of new antifungals, more recently a few new drugs of already existing classes have been introduced as important agents in the treatment and prevention of IFI. These represent small or large advantages and differences compared with existing available alternative therapy for deep and systemic mycoses. Voriconazole is a second-generation triazole antifungal drug, often prescribed as first-line therapy for candidemia, in non-neutropenic hosts, for invasive pulmonary aspergillosis and as prophylaxis of many systemic mycoses. In-vitro and in-vivo studies showed that voriconazole has broad-spectrum activity against most Candida species, Aspergillus species, fusariosis or scedosporiosis. Voriconazole has non-linear pharmacokinetics and, as substrate and inhibitor of cytochrome P450, it undergoes extensive hepatic metabolism that depends on age, genetic factors, and interactions with other drugs, which may lead to enhanced toxicity of the concomitant medication(s) or ineffective antifungal treatment. This book presents an update on voriconazole research, particularly its pharmacology, microbiology, toxicology, and clinical outcomes in order to optimize its use in daily clinical practice.
Автор: Bell Название: Mood And Anxiety Disorders In Children And Adolescents: A Psychopharmacological Approach: A Clinical Guide To Treatment ISBN: 1853179248 ISBN-13(EAN): 9781853179242 Издательство: Informa Рейтинг: Цена: 45750.00 T Наличие на складе: Нет в наличии. Описание: Psychopharmacological treatment of children and adolescents is a rapidly evolving field. It has become clear that a "psychopharmacological way of thinking" provides a useful model for explaining the nature of disorders to children and their families. For the clinician, a similar approach helps explain why, when, what and how to proscribe more logical. When the psychopharmacology and neurochemistry involved are understood, the choice of drug or therapy for each child is less daunting. Treatment can be tailored to specific symptoms and disease profiles, with side effects anticipated and explained. This book provides the information clinicians need to make informed choices in this complex field.
This clinically oriented book provides quick access to needed pain management guidelines presented in a clear, systematic format. The book assists practitioners in assessing pain in a variety of patient populations, as well as selecting patient-appropriate medications and interventions to achieve optimal pain management for adult patients.
The book focuses on treatment options for patients with chronic persistent pain, or pain that lasts beyond the normal healing time period of 3 to 6 months. Crucial information on managing the pain of chronic pain conditions is included, such as rheumatoid arthritis as well as difficult to treat conditions such as fibromyalgia and neuropathic pain.
The text is designed to guide the practitioner in the selection of medication management options as well as considering other types of treatment options such as acupuncture, energy therapies, psychological, and coping strategies. The book also presents essential information on safe prescribing and screening tools such as the Opioid Risk Tool (ORT) and screening tools for aberrant behaviors. It offers the newest guidelines on how to use a combination of pain screening tools to accurately assess the nature, intensity, and occurrence of patient pain.
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