Revival: Malaria (1989): Host Responses to Infection, Mary M. Stevenson

Автор: Maria M. Mota; Ana Rodriguez
Название: Malaria
ISBN: 3319452088 ISBN-13(EAN): 9783319452081
Издательство: Springer
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Цена: 149060.00 T
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Currently, malaria kills more than 300,000 people per year, making it a top priority of world leaders and international organizations, who are working towards implementing and coordinating efforts to eradicate this disease. An effective malaria vaccine is recognized as the key element that will decide between success and failure in this fight. At present, despite intensive research efforts, such a vaccine is not yet available for use. However, there are a number of advanced candidate vaccines with high chances of success in the short term.

Автор: S. M. Niaz Arifin,Gregory R. Madey,Frank H. Collin
Название: Spatial Agent–Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology
ISBN: 1118964357 ISBN-13(EAN): 9781118964354
Издательство: Wiley
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Цена: 113990.00 T
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Описание: Presents an overview of the complex biological systems used within a global public health setting and features a focus on malaria analysis Bridging the gap between agent–based modeling and simulation (ABMS) and geographic information systems (GIS), Spatial Agent–Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology provides a useful introduction to the development of agent–based models (ABMs) by following a conceptual and biological core model of Anopheles gambiae for malaria epidemiology. Using spatial ABMs, the book includes mosquito (vector) control interventions and GIS as two example applications of ABMs, as well as a brief description of epidemiology modeling. In addition, the authors discuss how to most effectively integrate spatial ABMs with a GIS. The book concludes with a combination of knowledge from entomological, epidemiological, simulation–based, and geo–spatial domains in order to identify and analyze relationships between various transmission variables of the disease. Spatial Agent–Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology also features: Location–specific mosquito abundance maps that play an important role in malaria control activities by guiding future resource allocation for malaria control and identifying hotspots for further investigation Discussions on the best modeling practices in an effort to achieve improved efficacy, cost–effectiveness, ecological soundness, and sustainability of vector control for malaria An overview of the various ABMs, GIS, and spatial statistical methods used in entomological and epidemiological studies, as well as the model malaria study A companion website with computer source code and flowcharts of the spatial ABM and a landscape generator tool that can simulate landscapes with varying spatial heterogeneity of different types of resources including aquatic habitats and houses Spatial Agent–Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology is an excellent reference for professionals such as modeling and simulation experts, GIS experts, spatial analysts, mathematicians, statisticians, epidemiologists, health policy makers, as well as researchers and scientists who use, manage, or analyze infectious disease data and/or infectious disease–related projects. The book is also ideal for graduate–level courses in modeling and simulation, bioinformatics, biostatistics, public health and policy, and epidemiology. S. M. Niaz Arifin, PhD, is Research Assistant Professor in the Department of Computer Science and Engineering at the University of Notre Dame.  A member of The Society for Computer Simulation, and American Society of Tropical Medicine and Hygiene, and the recipient of The American Society of Tropical Medicine and Hygiene Travel Award in 2011, his research interests include agent–based modeling and simulation, public health, data warehousing, and geographic information systems.   Gregory R. Madey, PhD, is Research Professor in the Department of Computer Science and Engineering at the University of Notre Dame.  A member of The Society for Computer Simulation, Institute of Electrical and Electronics Engineers Computer Society, and American Society of Tropical Medicine and Hygiene, his research interests include agent–based modeling and simulation, cyberinfrastructure, bioinformatics, biocomplexity, e–Technologies, open source software, disaster management, and health informatics.   Frank H. Collins, PhD, is Professor in the Department of Biological Sciences at the University of Notre Dame.  His research interests include genome level studies of arthropod vectors of human pathogens, the biology of malaria vectors with a focus on the development of molecular tools that will permit better resolution of questions about vector population ec

Автор: Stevenson
Название: Malaria (1989)
ISBN: 1138106062 ISBN-13(EAN): 9781138106062
Издательство: Taylor&Francis
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Цена: 153120.00 T
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Описание: The purpose of this book is to analyze and determine how a host responds to a blood stage malaria infection. It focuses on strategies for anti-malarial vaccination, genetic control of host resistance to malaria, and the contribution of the host genetic background to resistance or susceptibility to

Автор: Jacques Derek Charlwood
Название: The Ecology of Malaria Vectors
ISBN: 0367248603 ISBN-13(EAN): 9780367248604
Издательство: Taylor&Francis
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Цена: 178640.00 T
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Описание: This practical book covers all aspects of the biology of malaria vectors, with notes on the vectors of dengue. It is designed to fill the gap between very specialised texts and undergraduate books on general disease vectors, and is ideal as a textbook for postgraduate courses in entomology and mosquito vectors of disease.

Автор: Anna Margret Peterson, Gerald E Calamandrei
Название: Malaria: Etiology, Pathogenesis & Treatments
ISBN: 1621003639 ISBN-13(EAN): 9781621003632
Издательство: Nova Science
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Цена: 261880.00 T
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Описание: During World War II, Academy Award-winning director Frank Capra made propaganda films for the U.S. Government, such as Prelude to War, The Nazis Strike, The Battle of Britain, War Comes to America and The Negro Soldier. This analyses the cinematic and thematic techniques Capra employed in these films, linking them to the techniques and ideology of the director`s popular mainstream narrative films.

Автор: Stoute
Название: Complement Activation in Malaria Immunity and Pathogenesis
ISBN: 3319772570 ISBN-13(EAN): 9783319772578
Издательство: Springer
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Цена: 93160.00 T
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Описание: Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

Автор: Addmore Shonhai; Gregory L. Blatch
Название: Heat Shock Proteins of Malaria
ISBN: 9402402594 ISBN-13(EAN): 9789402402599
Издательство: Springer
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Цена: 121890.00 T
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Описание: This book describes the role of heat shock proteins in the life cycle of malaria parasites. It examines the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology.

Автор: Sherman Irwin W
Название: Malaria Vaccines: The Continuing Quest
ISBN: 1786340046 ISBN-13(EAN): 9781786340047
Издательство: World Scientific Publishing
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Цена: 116160.00 T
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In 2013, 200 million people were infected with malaria, resulting in over 584,000 deaths, with the potential to affect over half the world's population. Such is the widespread nature of malaria that it is increasingly believed only a vaccine will lead to its eradication.

Although the first attempt at a vaccine was made a century ago, it is only in the last 30 years that real progress in testing has been made, in the hope of discovering a molecule that can provide long-lasting protection against the disease. In July 2015, GlaxoSmithKline (GSK) announced that after 30 years of research it had received the green light from the European Medicines Agency for the world's first malaria vaccine, RTS, S, for use in African children aged 6 weeks to 17 months.

This book chronicles the development of RTS, S -- done in collaboration with the Walter Reed Army Institute for Research, the PATH Malaria Vaccine Initiative (MVI) and funded in part by the Bill and Melinda Gates Foundation -- as well as previous candidate vaccines. It also focusses on the continuing quest to find more effective vaccines against this continuing health crisis. Finally, it provides an easily understood background on recombinant DNA and monoclonal antibodies and places them in perspective to their contributions to malaria vaccine development.

This book serves as a convenient and easily accessible source of information for students, teachers, microbiologists, parasitologists, physicians, clinicians and research funders.

Автор: Abubakar Yaro
Название: Journey Through the World of Malaria
ISBN: 1629486361 ISBN-13(EAN): 9781629486369
Издательство: Nova Science
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Цена: 224920.00 T
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Описание: Our understanding of the pathogenic mechanisms of the malaria parasite has accumulated over the years with the advent of genomic knowledge playing a crucial role. Although great strides have been made in the field of malaria research, malaria still remains one of the most important public health issues in the world. Years ago, malaria was eradicated in some countries but global warming is playing a part in the spectacular re-emergence of malaria in some of these countries. There is still no effective vaccine, although some research has provided interesting data and anti-malaria drug resistance is the time bomb that has the potential of detonating the field of malaria research. Funder fatigue is now derailing the progress made over the years, which makes the field of malaria research look a bit gloomy. This book reviews the most important findings associated with malaria research over the couple of years with a timely overview. The topics covered include historical perspectives of the field of Malariology, life cycle of the parasite, recent advances in the epidemiology of malaria, pathogenesis with sub topics such as the parasite and immune system, virulence factors and clinical manifestations analysed in detail. The updated anti-malarial drug treatment, development and resistance are also discussed in detail. Finally, the social and economic burdens of malaria are looked at and various potential control strategies are put forward. This book will be essential to everyone interested in infectious diseases.

Автор: Watson Gianna
Название: New Frontiers in Malaria Research
ISBN: 1632428490 ISBN-13(EAN): 9781632428493
Издательство: Неизвестно
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Цена: 155570.00 T
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Автор: Krishna R. Dronamraju; Paolo Arese
Название: Malaria
ISBN: 1441921028 ISBN-13(EAN): 9781441921024
Издательство: Springer
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Цена: 163040.00 T
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Описание: This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called "Malaria Hypothesis", that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane's contribution from two directions: (a) it has been suggested that the "Malaria Hypothesis" was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane's malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration. For helpful discussions we thank Lucio Luzzatto, Alberto Piazza, Guido Modiano and David Roberts.

Автор: Henry M. Staines; Sanjeev Krishna
Название: Treatment and Prevention of Malaria
ISBN: 3034808089 ISBN-13(EAN): 9783034808088
Издательство: Springer
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Цена: 174130.00 T
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Описание: Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs.